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UniProtKB - C4LU91 (C4LU91_ENTHI)

Entry version 51 (29 Sep 2021)
Sequence version 1 (07 Jul 2009)
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Protein
Submitted name:

Transporter, major facilitator family

Gene

EHI_110390

Organism
Entamoeba histolytica
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.75.7, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transporter, major facilitator familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EHI_110390Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEntamoeba histolyticaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5759 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Amoebozoa › Evosea › Archamoebae › Mastigamoebida › Entamoebidae › Entamoeba
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001926 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		AmoebaDB:EHI5A_021210
AmoebaDB:EHI7A_022200
AmoebaDB:EHI8A_019440
AmoebaDB:EHI_110390
AmoebaDB:KM1_044150

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 55HelicalSequence analysisAdd BLAST20
Transmembranei75 – 94HelicalSequence analysisAdd BLAST20
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Transmembranei129 – 150HelicalSequence analysisAdd BLAST22
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23
Transmembranei199 – 221HelicalSequence analysisAdd BLAST23
Transmembranei330 – 355HelicalSequence analysisAdd BLAST26
Transmembranei367 – 386HelicalSequence analysisAdd BLAST20
Transmembranei398 – 419HelicalSequence analysisAdd BLAST22
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei457 – 479HelicalSequence analysisAdd BLAST23
Transmembranei499 – 520HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 523MFSInterPro annotationAdd BLAST489

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_514331_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		C4LU91

Identification of Orthologs from Complete Genome Data

More...OMAi		RQQMHVS

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR010658, Nodulin-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06813, Nodulin-like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4LU91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKSKKNVQP LVIEKNSLRY KYYHILRLKH FKCWRVMTLI AGFMLMLVGG 
        60         70         80         90        100
SIFSWSAYNI DLCEQMGYSF TQLNTLFSIG LLGVYFSLLS GFLFDNFGPR 
       110        120        130        140        150
GTLIFSFIFG TIGYLLFALQ VSFRFSSVTI LSYLFLFIAT QGCGALFQTA 
       160        170        180        190        200
IQTSSHNFPR NIRATIIGII TCGFPLSGSI YSFIYTNIFK NLNGGVHDYL 
       210        220        230        240        250
FFLCLTTCIG SFIGMVIMFI IPTDDPNNTS YSLTSSSYPN NVNNNEPFSL 
       260        270        280        290        300
STEVSNQSLI DSQNTNISFN ETEYQQTSIN SQKNVLPDNE SQNIQETSIQ 
       310        320        330        340        350
DPELNNSVQE FPQKQVRKCN TLKVFLQLDF YIYIIAIALV SGPSLSFISN 
       360        370        380        390        400
VSLILQSNGI NKSRIELLTG ITSLFHAIGI FLFCYGSDLL AKFHINKLMI 
       410        420        430        440        450
LSFLSFILLI LFSLVVLLQS FVIEVITWII PWFVGGILGV SLSLISERFG 
       460        470        480        490        500
VNNFGFNLGI TLTVVAVSNI FISIISGVFY DDYIKSGDSI CTGEICFHYT 
       510        520        530
FIISAGMVVC SFILFSFLVA KKFFTMKRQK
Length:530
Mass (Da):59,578
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C50F2D282924E29
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DS571151 Genomic DNA Translation: EAL51665.1

NCBI Reference Sequences

More...RefSeqi		XP_657049.1, XM_651957.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		GAT92166; GAT92166; CL6EHI_110390
rna_EHI_110390-1; rna_EHI_110390-1; EHI_110390

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3411354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ehi:EHI_110390

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS571151 Genomic DNA Translation: EAL51665.1
RefSeqiXP_657049.1, XM_651957.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

TCDBi2.A.1.75.7, the major facilitator superfamily (mfs)

Genome annotation databases

EnsemblProtistsiGAT92166; GAT92166; CL6EHI_110390
rna_EHI_110390-1; rna_EHI_110390-1; EHI_110390
GeneIDi3411354
KEGGiehi:EHI_110390

Organism-specific databases

VEuPathDBiAmoebaDB:EHI5A_021210
AmoebaDB:EHI7A_022200
AmoebaDB:EHI8A_019440
AmoebaDB:EHI_110390
AmoebaDB:KM1_044150

Phylogenomic databases

HOGENOMiCLU_514331_0_0_1
InParanoidiC4LU91
OMAiRQQMHVS

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR010658, Nodulin-like
PfamiView protein in Pfam
PF06813, Nodulin-like, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC4LU91_ENTHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4LU91
Secondary accession number(s): A0A175JF79
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: September 29, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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