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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19Nucleophile; for GATase activityUniRule annotation1
Active sitei633For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:ckrop_1743Imported
OrganismiCorynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717)Imported
Taxonomic identifieri645127 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001473 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi645127.ckrop_1743

Structurei

3D structure databases

ProteinModelPortaliC4LKV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 243Glutamine amidotransferase type-2InterPro annotationAdd BLAST225
Domaini310 – 449SISInterPro annotationAdd BLAST140
Domaini482 – 628SISInterPro annotationAdd BLAST147

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4LKV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWMKQPVST KISIIVPMCG IVGYVGRKQA LNIALAALER MEYRGYDSAG
60 70 80 90 100
IAVLDGRGAI NIEKKAGKLD NLRNAIDHIG TDHLTGATGI GHTRWATHGR
110 120 130 140 150
PNDVNAHPHL SYDGKVAIVH NGIIENFAAL REEVENTGIE LKSETDSEVA
160 170 180 190 200
AHLVALEYNQ GQNKGDFDAS VLAVLRRLEG AFSLLFTHAD YPDRIIAARR
210 220 230 240 250
SSPLIIGIGQ DEMFLGSDVA AFIEYTNKAV EIGQDTAVTI TKDGYTLTDF
260 270 280 290 300
YGNQQEGKPF TIDWDLAAAE KGGYDSFMEK EINEQPSAIR DTLAGHLQDG
310 320 330 340 350
RIVLDEQRLS EDELREVQKV FVVACGSAYH SGLLAKYAIE HWVRIPVEIE
360 370 380 390 400
VASEFRYRDP VLDSRTLVVA VSQSGETADT LEAVRHAKMQ NARVLAVCNT
410 420 430 440 450
NGAQIPREAD AVLYTHAGPE IGVASTKAFL AQIAANYIVG LALAQARGTK
460 470 480 490 500
YPDEVTAIYQ ELEQIPEKIQ QVLDQEEHIT NIAREMGAIR TMLFLGRHVG
510 520 530 540 550
FPVSLEGALK LKELAYIHAE GFPAGELKHG PIALIEDDLP VTVVVPSPRG
560 570 580 590 600
RAVLHSKIVS NIQEIRARGA KTIVIAEEGD DAVKPFANYL IEIPQTSTLL
610 620 630
QPLLSTVPLQ FLAAQIAREC GNEDIDKPRN LAKSVTVE
Length:638
Mass (Da):69,669
Last modified:July 7, 2009 - v1
Checksum:i7E6D44FFE78C1308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR18464.1

Genome annotation databases

EnsemblBacteriaiACR18464; ACR18464; ckrop_1743
KEGGickp:ckrop_1743

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001620 Genomic DNA Translation: ACR18464.1

3D structure databases

ProteinModelPortaliC4LKV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi645127.ckrop_1743

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR18464; ACR18464; ckrop_1743
KEGGickp:ckrop_1743

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiC4LKV9_CORK4
AccessioniPrimary (citable) accession number: C4LKV9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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