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UniProtKB - C4LBV2 (RPOB_TOLAT)

Entry version 65 (02 Dec 2020)
Sequence version 1 (07 Jul 2009)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:Tola_2783
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTolumonas auensis (strain DSM 9187 / TA4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri595494 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Aeromonadales › Aeromonadaceae › Tolumonas ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009073 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10002144901 – 1342DNA-directed RNA polymerase subunit betaAdd BLAST1342

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		C4LBV2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		595494.Tola_2783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		C4LBV2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0085, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000524_4_3_6

Identification of Orthologs from Complete Genome Data

More...OMAi		FMTWEGY

Family and domain databases

Conserved Domains Database

More...CDDi		cd00653, RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.150.10, 1 hit
2.40.270.10, 2 hits
2.40.50.150, 1 hit
3.90.1110.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01321, RNApol_bact_RpoB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462, DNA-dir_RNA_pol_bsu_external_1
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR007642, RNA_pol_Rpb2_2
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold

The PANTHER Classification System

More...PANTHERi		PTHR20856, PTHR20856, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04561, RNA_pol_Rpb2_2, 2 hits
PF04565, RNA_pol_Rpb2_3, 1 hit
PF10385, RNA_pol_Rpb2_45, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02013, rpoB, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C4LBV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSYTEKKR IRKDFGKRDQ VLETPYLLSI QLDSFKQFLD ADPEGAYGLE 
        60         70         80         90        100
AAFRSVFPIT SYSGTAELQY VSYRLGEPVF DVKECQIRGV TYSAPLRVKL 
       110        120        130        140        150
RLVLFDKEAA AGTVKEIKEQ EVYMGEIPLM TDNGTFVING TERVIVSQLH 
       160        170        180        190        200
RSPGVFFDHD KGKTHSSGKV LYNARVIPYR GSWLDFEFDA KDNLFVRIDR 
       210        220        230        240        250
RRKLPATIIL RALEFTTEEI LTTFFETIKF EIKDGKVLME LVPERLRGET 
       260        270        280        290        300
ATFDIVAGGD VVVEKGRRIT ARHIRQLEKA GISQIEVPVE YVVGKISARD 
       310        320        330        340        350
YVNPQTGEVM INANTALSLE AIANLSQAGF KQFEVLFTNE LDHGSYISET 
       360        370        380        390        400
LRIDSSTNRL EALVEIYRMM RPGEPPTKDA AEQLFENLFF SADRYDLSTV 
       410        420        430        440        450
GRMKFNSRLA RPDHIGSGIL SQDDIVDVMK QLIAIRNGKD DVDDIDHLGN 
       460        470        480        490        500
RRIRSVGEMA ENQFRVGLVR VERAVKERLS LGDLDAIQPQ DLINAKPISA 
       510        520        530        540        550
AVKEFFGSSQ LSQFMDQNNP LSEITHKRRI SALGPGGLTR ERAGFEVRDV 
       560        570        580        590        600
HPTHYGRLCP IETPEGPNIG LINSLAVYSR TNEYGFLETP YRKVIDGVIT 
       610        620        630        640        650
DEVDYLSAIE EGNFVIAQAN ANVDADARLK DELIPCRHKG ESTFMNAEQI 
       660        670        680        690        700
QYMDVSPQQV VSVAASLIPF LEHDDANRAL MGSNMQRQAV PTLRADKPLV 
       710        720        730        740        750
GTGMERAVAV DSGVTVVAKR GGTIDYVDAS RIVVKVNEDE LLPGEAGIDI 
       760        770        780        790        800
YNLTKYTRSN QNTCINQRPC VSVGEPVMLG DVLADGPSTD LGELALGQNM 
       810        820        830        840        850
RVAFMPWNGY NFEDSILVSE RVVQEDRLTT IHIQELSCIA RDTKLGPEEI 
       860        870        880        890        900
TADIPNVGEA ALSKLDESGI VYVGAEVKGG DILVGKVTPK GETQLTPEEK 
       910        920        930        940        950
LLRAIFGEKA SDVKDSSLRV PNGVYGTVID VQVFTRDGVE KDKRAKEVED 
       960        970        980        990       1000
MQLRDAKKDL TEEFKILEDG IFGRARSLLI ANGFGEDRLS KLDRKRWLEQ 
      1010       1020       1030       1040       1050
SLDDEGKQVE LEQIAEQHIA LKEEFDRKFE AKRQKIIQGD DLAPGVLKIV 
      1060       1070       1080       1090       1100
KVYLAVKRRI QPGDKMAGRH GNKGVISKIC PVEDMPYDDE GNPVDIVLNP 
      1110       1120       1130       1140       1150
LGVPSRMNIG QILEVHLGLA AKGIGEKIDR MVKEQRELAE LREFLQRVYD 
      1160       1170       1180       1190       1200
LGGSDQQQID IATLSDDDVR TLVQNLRKGL PVATPVFDGA KESEIKELLK 
      1210       1220       1230       1240       1250
LADKPESGQI TLFDGRTGMP FERVVTVGYM YMLKLNHLVD DKMHARSTGS 
      1260       1270       1280       1290       1300
YSLVTQQPLG GKAQFGGQRF GEMEVWALEA YGAAYTLQEM LTVKSDDVNG 
      1310       1320       1330       1340 
RTKMYKNIVD GDHRMEPGIP ESFNVLLKEI RSLGINIELE EE
Length:1,342
Mass (Da):149,814
Last modified:July 7, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B2D8492F93590F5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP001616 Genomic DNA Translation: ACQ94376.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ACQ94376; ACQ94376; Tola_2783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tau:Tola_2783

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001616 Genomic DNA Translation: ACQ94376.1

3D structure databases

SMRiC4LBV2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi595494.Tola_2783

Proteomic databases

PRIDEiC4LBV2

Genome annotation databases

EnsemblBacteriaiACQ94376; ACQ94376; Tola_2783
KEGGitau:Tola_2783

Phylogenomic databases

eggNOGiCOG0085, Bacteria
HOGENOMiCLU_000524_4_3_6
OMAiFMTWEGY

Family and domain databases

CDDicd00653, RNA_pol_B_RPB2, 1 hit
Gene3Di2.30.150.10, 1 hit
2.40.270.10, 2 hits
2.40.50.150, 1 hit
3.90.1110.10, 1 hit
HAMAPiMF_01321, RNApol_bact_RpoB, 1 hit
InterProiView protein in InterPro
IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462, DNA-dir_RNA_pol_bsu_external_1
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR007642, RNA_pol_Rpb2_2
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
PANTHERiPTHR20856, PTHR20856, 1 hit
PfamiView protein in Pfam
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04561, RNA_pol_Rpb2_2, 2 hits
PF04565, RNA_pol_Rpb2_3, 1 hit
PF10385, RNA_pol_Rpb2_45, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit
TIGRFAMsiTIGR02013, rpoB, 1 hit
PROSITEiView protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOB_TOLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C4LBV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 7, 2009
Last modified: December 2, 2020
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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