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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Uncinocarpus reesii (strain UAMH 1704)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184By similarity1
Active sitei386By similarity1
Active sitei448By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:UREG_05722
OrganismiUncinocarpus reesii (strain UAMH 1704)
Taxonomic identifieri336963 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenaceaeUncinocarpus
Proteomesi
  • UP000002058 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UREG_05722

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 519LumenalSequence analysisAdd BLAST487
Transmembranei520 – 540HelicalSequence analysisAdd BLAST21
Topological domaini541 – 638CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000041194933 – 638Pheromone-processing carboxypeptidase KEX1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiC4JTD3

Interactioni

Protein-protein interaction databases

STRINGi336963.XP_002585033.1

Structurei

3D structure databases

SMRiC4JTD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiC4JTD3
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4JTD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSCQPPPFL SSMVVRWLSV WIILASSAFA SAKCAADYYV RSLPGQPEGP
60 70 80 90 100
LLKMHAGHIE VDHENNGNLF FWHFQNRHIA NRQRTVIWLN GGPGCSSMDG
110 120 130 140 150
AMMEVGPYRL KDDHTLKYNE GSWDEFANLL FVDQPVGTGY SYANTNSYLH
160 170 180 190 200
ELDEMAAHFV TFMERWFELF PEYEHDDLYF AGESYAGQYI PYIAKAILDR
210 220 230 240 250
NKNETVIAQR RLWHLKGLLI GNGWFSPVEQ YLSYLPYVYK EGMVKNDSDE
260 270 280 290 300
AKGIERAHSD CVAELDRAKG DVKIHVDVCE KILSAILDVS NKSGHCVNMY
310 320 330 340 350
DVRLTDTFPS CGMNWPPDLK HLAPYLRRDD VTSALHINKD KKTGWTECAG
360 370 380 390 400
AVSSSFRPRK SKPSADLLPG LLESGVRIGL FSGAKDLICN HIGTEEFINK
410 420 430 440 450
MEWSGGKGFE LSPGVWAPRR DWTFEGETAG YYQEARNLTY VLFYNASHMV
460 470 480 490 500
PFDYARRSRD MLDRFLGVDI TSIGGNPTDS RIDGEKGALT SVGNHPNSTL
510 520 530 540 550
AEQREKEKLK AATWKAYYKS GEVALVVVVI AAGAWGFFLW RSRRQRQGSG
560 570 580 590 600
YLGIYPSLNG LSSGSLPRYR NKRSSRDIEA AAEFEASELE TLHDMDDRSP
610 620 630
GPSRDNYSVG EDSETEDEKR YPPTDFDRQD GTPSASRT
Length:638
Mass (Da):71,903
Last modified:July 7, 2009 - v1
Checksum:iE9974ECF7A5C0FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476617 Genomic DNA Translation: EEP80880.1
RefSeqiXP_002585033.1, XM_002584987.1

Genome annotation databases

EnsemblFungiiEEP80880; EEP80880; UREG_05722
GeneIDi8439360
KEGGiure:UREG_05722

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476617 Genomic DNA Translation: EEP80880.1
RefSeqiXP_002585033.1, XM_002584987.1

3D structure databases

SMRiC4JTD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336963.XP_002585033.1

Protein family/group databases

MEROPSiS10.007

Proteomic databases

PRIDEiC4JTD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEP80880; EEP80880; UREG_05722
GeneIDi8439360
KEGGiure:UREG_05722

Organism-specific databases

EuPathDBiFungiDB:UREG_05722

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiC4JTD3
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_UNCRE
AccessioniPrimary (citable) accession number: C4JTD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 7, 2009
Last modified: December 20, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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