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Entry version 57 (29 Sep 2021)
Sequence version 1 (28 Jul 2009)
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Protein

Apple domain-containing protein

Gene

BRAFLDRAFT_123458

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiportARBA annotation, Calcium transportARBA annotation, Ion transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.19.4.12, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apple domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BRAFLDRAFT_123458Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataLeptocardiiAmphioxiformesBranchiostomidaeBranchiostoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 90HelicalSequence analysisAdd BLAST23
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei161 – 190HelicalSequence analysisAdd BLAST30
Transmembranei196 – 217HelicalSequence analysisAdd BLAST22
Transmembranei256 – 278HelicalSequence analysisAdd BLAST23
Transmembranei298 – 319HelicalSequence analysisAdd BLAST22
Transmembranei326 – 353HelicalSequence analysisAdd BLAST28
Transmembranei359 – 378HelicalSequence analysisAdd BLAST20
Transmembranei385 – 403HelicalSequence analysisAdd BLAST19
Transmembranei459 – 478HelicalSequence analysisAdd BLAST20
Transmembranei490 – 516HelicalSequence analysisAdd BLAST27
Transmembranei522 – 543HelicalSequence analysisAdd BLAST22
Transmembranei555 – 574HelicalSequence analysisAdd BLAST20
Transmembranei594 – 612HelicalSequence analysisAdd BLAST19
Transmembranei621 – 639HelicalSequence analysisAdd BLAST19
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Transmembranei774 – 792HelicalSequence analysisAdd BLAST19
Transmembranei843 – 868HelicalSequence analysisAdd BLAST26
Transmembranei900 – 920HelicalSequence analysisAdd BLAST21
Transmembranei1029 – 1056HelicalSequence analysisAdd BLAST28
Transmembranei1062 – 1083HelicalSequence analysisAdd BLAST22
Transmembranei1095 – 1114HelicalSequence analysisAdd BLAST20
Transmembranei1134 – 1152HelicalSequence analysisAdd BLAST19
Transmembranei1161 – 1179HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7739.XP_002590091.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1192 – 1280AppleInterPro annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 449DisorderedSequence analysisAdd BLAST25
Regioni1286 – 1524DisorderedSequence analysisAdd BLAST239

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi426 – 445Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1332 – 1358Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1366 – 1382Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1383 – 1412Basic residuesSequence analysisAdd BLAST30
Compositional biasi1425 – 1439Polar residuesSequence analysisAdd BLAST15
Compositional biasi1440 – 1454Pro residuesSequence analysisAdd BLAST15
Compositional biasi1458 – 1483Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1307, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C3ZMW2

Database of Orthologous Groups

More...
OrthoDBi
1168500at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004481, K/Na/Ca-exchanger
IPR004837, NaCa_Exmemb
IPR003609, Pan_app
IPR030245, SLC24A5

The PANTHER Classification System

More...
PANTHERi
PTHR10846, PTHR10846, 4 hits
PTHR10846:SF61, PTHR10846:SF61, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01699, Na_Ca_ex, 5 hits
PF00024, PAN_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00473, PAN_AP, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00367, TIGR00367, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50948, PAN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3ZMW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METVTMGIEG IVDTSWSEAG LRLKGEQHTP PVSREGNIDT CLCRPQLTRM
60 70 80 90 100
RLLTTSHRAK RRKGRWQVTA AIFLALLGAF SAIVFLQTLF TEQDFTRRVY
110 120 130 140 150
ATSVTEMDTD GDETVQKEPE YPFKAPSQLW RRVLWIIGLP LTILLVGTVP
160 170 180 190 200
DCRRDKWKRW YPVSFVMSVA WIGVFTYILV WMVTVIGFTV GIPDTVMGLT
210 220 230 240 250
LVAIGTSVPD AMSSVLVSKE DAANISSPGA NCSRPQAISH YPADVFTQEQ
260 270 280 290 300
RRQGAVILHV IATLYMFLAL AIICDDYFVP SLERISEALG LQPDVAGATF
310 320 330 340 350
MAAGSSAPEL FTSIFGVFVS RDDIGVGTIV GSAVFNLLFI VGLCGLLVGT
360 370 380 390 400
AITLTLWPLL RDCSVFLISV AALVIVMYDG KIHWYEALTL VVLYCLYVVL
410 420 430 440 450
MYFNPRLSAA FSSCCSRAAQ SENEETSLMK PEKDTDGEET AQEEPKYPFK
460 470 480 490 500
APSQPWRRVL WVVGLPLTLL LVGTVPDCRR DKWKSWYPVS FVMSVAWIGV
510 520 530 540 550
FTYILVWMVT VIGFTVGIPD TVMGLTLVAI GTSVPDAMSS VLVSKEGEGD
560 570 580 590 600
MAVSNAVGSN VFDILVGLGV PWFFKTVVIE TNSVVPIQSG GLVYSAITLL
610 620 630 640 650
STVLILLFTM WLNRWRLDRK LGVICSCLYA LFITLATLYE LNVFGDFNPP
660 670 680 690 700
TCPGTMDRAC HRPSAAHLPV QHTRQHLPTA ARGARRRKRT WQVTAAVFLA
710 720 730 740 750
LWGVLGVVVA LQRAFGGESI TRTVYTATVR GVESLELDAA INGTGTAAGQ
760 770 780 790 800
NCSPPALSRF PADVFTQEQR RQGAVILHVI ATLYMFLALA IICDDYFVPA
810 820 830 840 850
LERISEALRL QPDVAGATFM AAGSSAPELF TSIFGVFVSR DDIGVGTIVG
860 870 880 890 900
SAVFNLLFIV GLCGLLAITL TLWPLLRDCS VYLISVAALV IVIYDEQVHW
910 920 930 940 950
YEACILVCLY FSYVLLMYFN RRLSSGFTRR FPAADDLLQT RQTGQYEKTP
960 970 980 990 1000
LIKTDNRKEA GQFVQTSQVD AVTTTNSEET IQEEPESPLS VPSEPWRRVL
1010 1020 1030 1040 1050
WVIGLPLTLL LVGTVPDCRR DKWKRWYPVS FVMSVAWIGV FTYILVWMVT
1060 1070 1080 1090 1100
VIGFTAGIPD TVMGLTLVAI GTSVPDAMSS VLVSKEGLGD MAVSNAVGSN
1110 1120 1130 1140 1150
VFDILVGLGV PWFFRTVVVQ TNSVVPIQSG GLVYSAVTLL STVLVLLFTM
1160 1170 1180 1190 1200
WLNRWRLDRK LGVICSCLYA VFITLATLYE LNVFGDFNPP TCTGSAPIPI
1210 1220 1230 1240 1250
LQKFEWTPGV ITYGNDDRTV EDVDTADGCA VLCLQESTFI CKSFDFRSKE
1260 1270 1280 1290 1300
KVCMLSKGNS YTAGVGLRLA AGADLYEVLP DYIPTEVPTT TARPTAAKPT
1310 1320 1330 1340 1350
DPTTPEAEGQ DDPNAGGLQD QPSAEPVSTK RNGGVDKTDQ DKETQEDGDM
1360 1370 1380 1390 1400
SDGKARRKDR EGRRKKKRGK ENGEEDNGGK NGRRGRKRGR QGRRNGERKK
1410 1420 1430 1440 1450
NRRGKGRNGG NGKRPSKKMD VENTNDVTKT SSPTTPKTTV PPRQTTPDPE
1460 1470 1480 1490 1500
PYQTPSPLDS DIDATSVAMT TEIVPSDGDL SETPNSLRGE VDDTPAMGEG
1510 1520
NTATADAGTG DEPGVAGNNT EGLP
Length:1,524
Mass (Da):166,689
Last modified:July 28, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEFBB91B4E36990C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG666648 Genomic DNA Translation: EEN46102.1

NCBI Reference Sequences

More...
RefSeqi
XP_002590091.1, XM_002590045.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666648 Genomic DNA Translation: EEN46102.1
RefSeqiXP_002590091.1, XM_002590045.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7739.XP_002590091.1

Protein family/group databases

TCDBi2.A.19.4.12, the ca(2+):cation antiporter (caca) family

Phylogenomic databases

eggNOGiKOG1307, Eukaryota
InParanoidiC3ZMW2
OrthoDBi1168500at2759

Family and domain databases

InterProiView protein in InterPro
IPR004481, K/Na/Ca-exchanger
IPR004837, NaCa_Exmemb
IPR003609, Pan_app
IPR030245, SLC24A5
PANTHERiPTHR10846, PTHR10846, 4 hits
PTHR10846:SF61, PTHR10846:SF61, 4 hits
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 5 hits
PF00024, PAN_1, 1 hit
SMARTiView protein in SMART
SM00473, PAN_AP, 1 hit
TIGRFAMsiTIGR00367, TIGR00367, 2 hits
PROSITEiView protein in PROSITE
PS50948, PAN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3ZMW2_BRAFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3ZMW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 29, 2021
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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