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Protein

Histone deacetylase

Gene

BRAFLDRAFT_103129

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi499ZincUniRule annotation1
Metal bindingi501ZincUniRule annotation1
Metal bindingi507ZincUniRule annotation1
Metal bindingi583ZincUniRule annotation1
Active sitei635UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:BRAFLDRAFT_103129Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI103129

Structurei

3D structure databases

ProteinModelPortaliC3Z354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 86HDAC4_GlnInterPro annotationAdd BLAST68
Domaini507 – 823Hist_deacetylInterPro annotationAdd BLAST317

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili64 – 84Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
InParanoidiC3Z354
KOiK11406
OMAiSITPMFV

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR033660 HDAC4
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PTHR10625:SF100 PTHR10625:SF100, 2 hits
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 3 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

C3Z354-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIDGREQQG SAGGEVEDRL NYIKQQQALQ RELLHQHFRQ QEEQLARQHQ
60 70 80 90 100
AELQQHLHLQ KLQALREQQE LAQARGKLQE KQSERQKQLL AGKKKENSAM
110 120 130 140 150
ASTEVKEKLQ TFILSKKQRE AAANSLHQSP SLSMAHWPHG SLGHMPMSGD
160 170 180 190 200
LAAAAAYKGH PMLGTYGSNA DFPLRKTASE PNLKVRSRLK QKVAERRSSP
210 220 230 240 250
LLRRRDGIGG SFKTRKPLSN KIHIQVPQSA PGSGPSSPRS SHSNMVIAGN
260 270 280 290 300
HEESGVQPAV VPGRMVGGNA ADFTLYTSPS LPNISLGLAN SSSSAETTQT
310 320 330 340 350
GEKVVQSALS REAELRAMAA ARLGQPLTVV PAREPQPAPR SDEGLGTAGH
360 370 380 390 400
SPSNCAASAS RPLGRTHSAP LPGTHMHHLQ QQVLHPQHYM QALLRQHVVN
410 420 430 440 450
KQQLGNGDIA KQPRPEPHPE ETEEELKEHT QVTVKQEPLD SDEENEEEES
460 470 480 490 500
CRQLDMNIDG TSTHRPLSRA QSSPATYNSV KSVFTTGVVY DPLMLKHSCS
510 520 530 540 550
CGNNSYHPEH SGRIQSVWSR LQETGLVNRC ERVRSRKATI DELKTCHSEQ
560 570 580 590 600
HVYLYGTNPL HRQKQDSKKL AGGLQKSFKY LPCGGLGVDA DTIWNELHSP
610 620 630 640 650
SALRMAAGCV IELAFKVAQG ELKNGFAVVR PPGHHAEVDQ AMGFCFFNSI
660 670 680 690 700
AVTARLLVQR LKLNKVLIVD WDVHHGNGTQ QMFYEDGQVL YVSLHRWDSG
710 720 730 740 750
NFFPGTGAPD ECGNGAGLGK NVNISFSGGL EPPMGDAEYM AAFRTVVMPI
760 770 780 790 800
AVEFSPDLVL VSAGFDTAEG HAPQLGGYKV TPKCFGHMTK QLMSVAGGRV
810 820 830 840 850
VLALEGGYDL AAICDCSEMC VQALLGDELP PLPKEIIEQP PNKNAVTSLE
860 870 880 890 900
ETIRRQTPHW SSLSRYASTV GYSLYEAYER EKEEADTVSA LASLSVASAP
910 920
GVGMPASANS ERNHKPQPLE DTINGL
Length:926
Mass (Da):101,141
Last modified:July 28, 2009 - v1
Checksum:iF1ECED084036E917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666576 Genomic DNA Translation: EEN52898.1
RefSeqiXP_002596886.1, XM_002596840.1

Genome annotation databases

GeneIDi7208855
KEGGibfo:BRAFLDRAFT_103129

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666576 Genomic DNA Translation: EEN52898.1
RefSeqiXP_002596886.1, XM_002596840.1

3D structure databases

ProteinModelPortaliC3Z354
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7739.JGI103129

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7208855
KEGGibfo:BRAFLDRAFT_103129

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
InParanoidiC3Z354
KOiK11406
OMAiSITPMFV

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR033660 HDAC4
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PTHR10625:SF100 PTHR10625:SF100, 2 hits
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 3 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC3Z354_BRAFL
AccessioniPrimary (citable) accession number: C3Z354
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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