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Entry version 45 (08 May 2019)
Sequence version 1 (28 Jul 2009)
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Protein

Elongator complex protein 1

Gene

BRAFLDRAFT_286073

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongator complex protein 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BRAFLDRAFT_286073Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7739.XP_002597833.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELP1/IKA1 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1920 Eukaryota
COG5290 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C3Z0U1

KEGG Orthology (KO)

More...
KOi
K11373

Identification of Orthologs from Complete Genome Data

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OMAi
CTQTELA

Database of Orthologous Groups

More...
OrthoDBi
180136at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006849 Elp1
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12747 PTHR12747, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04762 IKI3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017233 IKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3Z0U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNLELLQCV HQECVPASLG VPCCIAVDSD TGTVYAGTDT GLVALDGDSH
60 70 80 90 100
SVLSSVSLRE AGYLCEADNS HLVGIQYLYD QDSVCVATSS GDVILWNIPT
110 120 130 140 150
QELECVGTVD SGLTCMAWSP NQDLVLLTTG EEKMVMMTSD FNPISETSIN
160 170 180 190 200
QEEFGEAEFI TAGWGKKETQ FHGSEGKQAA FQQKESVSPA LPWDDRRPRV
210 220 230 240 250
SWCRDAFVVS SVSPVDGARR LRVWNRDCVL QATSENVSML EQALSWKPSG
260 270 280 290 300
SLIASTQRKP HRHEVVFFEK NGLRHGGFVL PFGKDEIKVT HLLLWNSDST
310 320 330 340 350
VLAVWMEELA PVQEKGAGDE DKSFTPSTYV QLWTVSNYHW YLKQSLHFGK
360 370 380 390 400
SQADRPTAVV WDAEHPYRLH LVCHGGRYVM YEWTWVINRS DGRTSEDNSY
410 420 430 440 450
VAVIDGDKVL MTPFRQVVIP PPMSAYSLQL PTPVSQVLFS PSPGVNDLAA
460 470 480 490 500
VLTDGTVVFY TLDLKQPVSR DTSVCVNAAG GTGFKPAVRM HVQHRRLGLS
510 520 530 540 550
CCMLQEKWRC AQTLHHFVWL AEDQLLTVSW DPSSSTSVLY HLGTQEEQAT
560 570 580 590 600
LIHQVAVEGR VYQLCRSSEG SSVAIELTDG TVLRYYMVAA CPVLEPWRSQ
610 620 630 640 650
DGVPVKFSVL CSQMGLCSMG GHETVLGLSD KFRLFINGDE ICSNCTSFAV
660 670 680 690 700
HNDHLLLTTH AHTCACLPLH TASKGGYGNS QCVSDLTIDE KTRRVERGSR
710 720 730 740 750
LVTVVPWDTK VILQMPRGNL ETVHPRTLVL GLVQKMIDSQ QFLEAFLVMR
760 770 780 790 800
KHRVNLNLLC DLNPKVFLSC VPEMVTQLKD INFINLFLTE LREEDVTKTM
810 820 830 840 850
YSDYCCSPDG ENSWDLQVKS KMDQVCDVVK DALEGLDSEK YLLGILTCHI
860 870 880 890 900
RKAQPELEVC LQKIQEIWDT PPQSPDGVSA EEALNYVLLL VDVNELFNVA
910 920 930 940 950
LGTYNLRLVL MVAEKSQKDP KEYLPFLKQL QNMEENVQRY TIDLHLKRYH
960 970 980 990 1000
KAIQHLSKCG PDRFADLLAL VKEHKLYRSA LQLYTTESKE YRDITVEYGE
1010 1020 1030 1040 1050
HLQKKGHVEE AGLMFSRCEE WEKALQAYEQ CCSWRQALCV SCRLHYSTQQ
1060 1070 1080 1090 1100
TSQLALRMAG FLRNNGRHCE AAVLLEQYVQ DEEGAIITLL EGSQWEEALR
1110 1120 1130 1140 1150
VIYQHSRTDI IDTNFKPALL EASQRQLAFL QENKALFIRH TDRLAVVRKE
1160 1170 1180 1190 1200
KSMACQKIQK WNTVPRSRTR GPESDLDVFF ATPTYILISG KSLDNIYCFT
1210 1220 1230 1240 1250
FYCCFFRRSS KSRRKAERKK LSLREGSPYE DSALLSALKD IIEAVDKSKD
1260 1270 1280 1290 1300
DVHQLLKMLV LFGLDSEAGM IQSSLEGTLS LIDSCTSEIW QTGILYSSLL
1310 1320 1330 1340
QTLGPHSTVN SILASMNAGP QPVDDTVVAV PPPARLKDSK WKLSILEGT
Length:1,349
Mass (Da):151,614
Last modified:July 28, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42F7465EAB27BD41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
GG666570 Genomic DNA Translation: EEN53845.1

NCBI Reference Sequences

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RefSeqi
XP_002597833.1, XM_002597787.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
7208561

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bfo:BRAFLDRAFT_286073

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666570 Genomic DNA Translation: EEN53845.1
RefSeqiXP_002597833.1, XM_002597787.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7739.XP_002597833.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7208561
KEGGibfo:BRAFLDRAFT_286073

Phylogenomic databases

eggNOGiKOG1920 Eukaryota
COG5290 LUCA
InParanoidiC3Z0U1
KOiK11373
OMAiCTQTELA
OrthoDBi180136at2759

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006849 Elp1
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR12747 PTHR12747, 1 hit
PfamiView protein in Pfam
PF04762 IKI3, 1 hit
PIRSFiPIRSF017233 IKAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3Z0U1_BRAFL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3Z0U1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 8, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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