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Entry version 71 (29 Sep 2021)
Sequence version 1 (28 Jul 2009)
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Protein

Non-specific serine/threonine protein kinase

Gene

BRAFLDRAFT_67342

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseARBA annotation, Transferase
LigandNucleotide-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BRAFLDRAFT_67342Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataLeptocardiiAmphioxiformesBranchiostomidaeBranchiostoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001554 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 67ANKPROSITE-ProRule annotationAdd BLAST33
Repeati290 – 322ANKPROSITE-ProRule annotationAdd BLAST33
Repeati323 – 355ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini375 – 572RocInterPro annotationAdd BLAST198
Domaini922 – 990DeathInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1054 – 1081DisorderedSequence analysisAdd BLAST28
Regioni1098 – 1119DisorderedSequence analysisAdd BLAST22
Regioni1132 – 1265DisorderedSequence analysisAdd BLAST134
Regioni1375 – 1401DisorderedSequence analysisAdd BLAST27
Regioni1443 – 1482DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1150 – 1190Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi1191 – 1207Polar residuesSequence analysisAdd BLAST17
Compositional biasi1217 – 1234Basic residuesSequence analysisAdd BLAST18

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C3XQ60

Database of Orthologous Groups

More...
OrthoDBi
707272at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 2 hits
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR039788, NOL4/NOL4L
IPR027417, P-loop_NTPase
IPR020859, ROC_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12449, PTHR12449, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00531, Death, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits
SM00005, DEATH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 3 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51424, ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3XQ60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKNFFKASR EGDVSGLRSF KKGGGDINIK EKGSLRRTPL HEAAAKGRVK
60 70 80 90 100
ISQILITKGA EVNVKDFAAH ETKSSRTFRT QAHETECSRT FRTQAHETEC
110 120 130 140 150
SRTFRTQAHE TECSRTFSTQ AHETECSHTF RTKAHETECS RTFRTQAHET
160 170 180 190 200
ECSRTFRTQA HETECSRTFS TQAHETECSH TFRTKAHETE CSRTFRTQAH
210 220 230 240 250
ETECSRTFRT QAHETECSRT FSTQAHETEC SHTFRTKAHE TGCSHTFRTQ
260 270 280 290 300
AHETECSRTF RTQAHETECS RTFHTQAHET ECSRTFRTQA HETPLHSAAG
310 320 330 340 350
QGRNGVVELL LAKGGAVNAT DEAENAPLHC AAAGDHIEAV KLLLSQGADV
360 370 380 390 400
FARNKARQKQ IDRQIMQHDL LSKDGGVKVN KIKLLVCGDE ATGKSTLIGS
410 420 430 440 450
LCRTGIKAVF TREKHKQTDT EVRSPTAGVD VGNMTVPNAG EFAIFDFAGQ
460 470 480 490 500
AEYYVTHAML MHAKLGVYVT VYNITDDAET QTQQLQRWLR MIKAGNADPS
510 520 530 540 550
VSPKVVLVGS HGDKIDKQKG MSRAAALLRS MRGQFRHQLD ISTETFVLDC
560 570 580 590 600
VVSQSPDMDR LRKHLACLKQ EVLKDQPQLP KLCSEIVRKV PGWCKNNLGG
610 620 630 640 650
GAPVLRWPEY VQAVKEIDPL VKEDFLLKST EYLNDIAEIL LVKTTSSDPI
660 670 680 690 700
VVLTPPWLCG YVFGPLLAPE NFPIDHIERE SDDHVTFREI SRVFSRTVSP
710 720 730 740 750
KILVSILREF QICHTFDGQD FIFPSLLRRL PPLKEIWKPT KSEPVVYFGS
760 770 780 790 800
QVACKDATDS FSPDFFPRLQ TDLLKEHPGT FPVKPAIWKD GMIFTDGKSE
810 820 830 840 850
GLIAMSQGNM ACNIVVRNPS GYREYCYYLL ERIQRKLSKV LEESSPGTSV
860 870 880 890 900
VERVLSSRAL REHRDTFYSY DRKAVQESAR ENGSLSHPDL QWSERVYDLV
910 920 930 940 950
VSQEGPNKHT FQLVAKQLRS TEWRELGREL GLSDSKLDRV QKDYSGDLRE
960 970 980 990 1000
TVYRMLTMWE EEADCSCSVG REKLSKALVT VNRRDIADEL MCDESPCLFT
1010 1020 1030 1040 1050
LPHTTPGLSF CVSSAGSEAH GDSLPGFRVL VRDFPLSAMA KPKVCSVCTL
1060 1070 1080 1090 1100
PVKGHRGPHG RGKCTAGFSP GSDNNSDSIE ERVRRSLKKL KRDSKAKELA
1110 1120 1130 1140 1150
KGLWSEASEE ERVPTARDLR EDDDLADRVD KTLDEIFGKK PRKRSSSRRK
1160 1170 1180 1190 1200
DRKDTSQSPS RSRSPDAARS RRRLKNIDDL LGKRPVSSRK RSSSDSTTRS
1210 1220 1230 1240 1250
STSRSRSTDG SRSRRRRSND HKGHRRRHRS ARRRYSSDSR SSSSPRRRRR
1260 1270 1280 1290 1300
GKKSGRTKTI NDSASSRVKI EWPHHHVHFP GKGKGGDGCV TYDDLSTSMF
1310 1320 1330 1340 1350
VHGFVKNLLE KKHVKRSVRI RLEHLSDLMF DAAYYDWGIV RETHASVLYA
1360 1370 1380 1390 1400
MENGTISWSS SKETIDNTRE RSYRAQAGVS HPPAAPRAQA RSTARDPNRP
1410 1420 1430 1440 1450
RWCEAYQHGN CQQGPEHWDP RWGQVKHICC MCLLVRRVEE EHPKTECRHG
1460 1470 1480
PRSFRQPPGD NTRRAAGFSS QPGATGTGGG HY
Length:1,482
Mass (Da):167,379
Last modified:July 28, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i147BA4AAC2099DA9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG666451 Genomic DNA Translation: EEN70081.1

NCBI Reference Sequences

More...
RefSeqi
XP_002614072.1, XM_002614026.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666451 Genomic DNA Translation: EEN70081.1
RefSeqiXP_002614072.1, XM_002614026.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG0032, Eukaryota
InParanoidiC3XQ60
OrthoDBi707272at2759

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 2 hits
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR039788, NOL4/NOL4L
IPR027417, P-loop_NTPase
IPR020859, ROC_dom
PANTHERiPTHR12449, PTHR12449, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00531, Death, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM00005, DEATH, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 3 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51424, ROC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3XQ60_BRAFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3XQ60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 29, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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