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Entry version 81 (16 Jan 2019)
Sequence version 2 (05 Oct 2010)
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Protein

Protein NLRC5

Gene

Nlrc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.1 Publication

Caution

Supposed to contain a CARD domain at the N-terminus. However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi229 – 236ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NLRC5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nlrc5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3612191 Nlrc5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003978671 – 1915Protein NLRC5Add BLAST1915

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
C3VPR6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
C3VPR6

PeptideAtlas

More...
PeptideAtlasi
C3VPR6

PRoteomics IDEntifications database

More...
PRIDEi
C3VPR6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
C3VPR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
C3VPR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, thymus and lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interferon gamma. By LPS and viruses (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000074151 Expressed in 86 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
C3VPR6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
C3VPR6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C3VPR6, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11915
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJMNMR-A1-96[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
C3VPR6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
C3VPR6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini223 – 542NACHTPROSITE-ProRule annotationAdd BLAST320
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati622 – 646LRR 1Add BLAST25
Repeati716 – 740LRR 2Add BLAST25
Repeati744 – 771LRR 3Add BLAST28
Repeati772 – 796LRR 4Add BLAST25
Repeati871 – 898LRR 5Add BLAST28
Repeati900 – 923LRR 6Add BLAST24
Repeati930 – 953LRR 7Add BLAST24
Repeati1006 – 1033LRR 8Add BLAST28
Repeati1034 – 1055LRR 9Add BLAST22
Repeati1138 – 1161LRR 10Add BLAST24
Repeati1162 – 1184LRR 11Add BLAST23
Repeati1240 – 1263LRR 12Add BLAST24
Repeati1265 – 1292LRR 13Add BLAST28
Repeati1348 – 1371LRR 14Add BLAST24
Repeati1481 – 1504LRR 15Add BLAST24
Repeati1519 – 1542LRR 16Add BLAST24
Repeati1552 – 1575LRR 17Add BLAST24
Repeati1576 – 1598LRR 18Add BLAST23
Repeati1603 – 1626LRR 19Add BLAST24
Repeati1631 – 1654LRR 20Add BLAST24
Repeati1659 – 1682LRR 21Add BLAST24
Repeati1687 – 1711LRR 22Add BLAST25
Repeati1715 – 1738LRR 23Add BLAST24
Repeati1741 – 1768LRR 24Add BLAST28
Repeati1769 – 1795LRR 25Add BLAST27
Repeati1821 – 1845LRR 26Add BLAST25
Repeati1849 – 1872LRR 27Add BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168392

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108194

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
C3VPR6

KEGG Orthology (KO)

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KOi
K22615

Identification of Orthologs from Complete Genome Data

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OMAi
CHCVGET

Database of Orthologous Groups

More...
OrthoDBi
19417at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C3VPR6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 8 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 7 hits
PF05729 NACHT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00367 LRR_CC, 13 hits
SM00369 LRR_TYP, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50837 NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: C3VPR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAESIRLNN ENLWAWLVRL LSKNPEWLSA KLRSFLPTMD LDCSYEPSNP
60 70 80 90 100
EVIHRQLNRL FAQGMATWKS FINDLCFELD VPLDMEIPLV SIWGPRDEFS
110 120 130 140 150
KQLGAGEESC PGPQLYHGAK RPFQSYGSSP RRKNSKKQQL ELAKKYLKLL
160 170 180 190 200
KTSAQQWHGG VCPGAWLTPH SPQTYIPPVL QWSRATAPLD AQEGATLGDP
210 220 230 240 250
EAADNIDVSI QDLFSFKAHK GPRVTVLLGK AGMGKTTLAY RLRWRWAQGQ
260 270 280 290 300
LDRFQALFLF EFRQLNMITQ LPTLPQLLFD LYLMPESEPD AVFQYLKENA
310 320 330 340 350
QEVLLIFDGL DEALHADSVG TDNAGSALTL FSELCHGNLL PGCWVMTTSR
360 370 380 390 400
PGKLPSCVPT EAATVHMWGF DGLRVEKYVT CFFSDLLSQE LALKEMRTNA
410 420 430 440 450
RLRGMCAIPA LCTVTCFCLR RLLPGSSPGQ SAALLPTITQ LYLQMVETFS
460 470 480 490 500
PSETLLDTSI LGFGKVALRG LDTGKVVFSV EDISPQLMSF GAVHSLLTSF
510 520 530 540 550
CIHTRPGHEE IGYAFVHLSL QEFFAALYLM ASHTVDKDTL VEYVTLNSHW
560 570 580 590 600
VLRTKGRLGL SDHLPAFLAG LASHTCHMFL CQLAQQDRAW VGSRQAAVIQ
610 620 630 640 650
VLRKLASRKL TGPKMIELYH CVAETQDLEL ARFTAQSLPS RLSFHNFPLT
660 670 680 690 700
HADLAALANI LEHRDDPIHL DFDGCPLEPH CPEALVGCGQ VENLSFKSRK
710 720 730 740 750
CGDAFAEALC RSLPTMGSLK TLGLTGSRIT AQGISHLIQT LPLCSQLEEV
760 770 780 790 800
SLHDNQLKDP EVLSLVELLP SLPKLQKLDL SRNSFSRSIL LSLVKVAITC
810 820 830 840 850
PTVRKLQVRE LDLIFYLSPV TETATQQSGA SDVQGKDSLK EGQSRSLQLR
860 870 880 890 900
LQKCQLRIRD AEALVELFQK SPQLEEVNLS GNHLEDDGCR LVAEAASQLH
910 920 930 940 950
IAQKLDLSDN GLSQTGVTYV LKAMSTCGTL EDLHISLLNN TVVLTFAQEP
960 970 980 990 1000
REQEGSCKGR APLISFVSPV TSELSQRSRR IRLTHCGFLA KHTETLCEAL
1010 1020 1030 1040 1050
RASCQTHNLD HLDLSDNSLG GKGVILLTEL LPGLGPLKSL NLSRNGLSMD
1060 1070 1080 1090 1100
AVFSLVQCLS SLQWVFHLDV SLESDCIFLR GAGTSRDALE PKFQTGVQVL
1110 1120 1130 1140 1150
ELSQRYTSRS FCLQECQLEP TSLTFLCATL EKSPGPLEVQ LSCKSLSDDS
1160 1170 1180 1190 1200
LKILLQCLPQ LPQLSLLQLR HTVLSSRSPF LLADIFNLCP RVRKVTLRSL
1210 1220 1230 1240 1250
CHAVLHFDSN EEQEGVCCGF PGCSLSQEHM ETLCCALSKC NALSQLDLTD
1260 1270 1280 1290 1300
NLLGDIGLRC LLECLPQLPI SGWLDLSHNN ISQEGILYLL ETLPSYPNIQ
1310 1320 1330 1340 1350
EVSVSLSSEQ IFRMCFSKKE GAGTSLRLCE CSFSPEQVSK LASSLSQAQQ
1360 1370 1380 1390 1400
LTELWLTKCH LDLPQLTMLL NLVNRPTGLL GLRLEEPWVD SVSLPALMEV
1410 1420 1430 1440 1450
CAQASGCLTE LSISEIQRKL WLQLEFPHQE GNSDSMALRL AHCDLETEHS
1460 1470 1480 1490 1500
HLMIQLVETY ARLQQLSLSQ VSFNDNDGTS SKLLQNILLS SCELKSFRLT
1510 1520 1530 1540 1550
FSQVSTKSLT HLAFGLGHCH HLEELDFSNN SLREEDTELL MGALQGTCRL
1560 1570 1580 1590 1600
KKLHLSFLPL GASSLALLIQ GLSRMTLLQD LCLSHNQIGD VGTQCLAAIL
1610 1620 1630 1640 1650
PKLPELRKFD LSHNQIGDVG TQCLAAILPK LPELRKFNLS HNQIGHVGTQ
1660 1670 1680 1690 1700
CLAAILPKLP ELRKFDLSRN QIGDVGTQCL AAILPKLPEL RKFDLSGNRI
1710 1720 1730 1740 1750
GPAGGVQLVK SLTHFEHLEE IKLGNNALGE PTALELAQRL PPQLRVLCLP
1760 1770 1780 1790 1800
SSHLGPEGAL GLAQALEQCP HIEEVSLAEN NLAGGVPRFS KRLPLLRQID
1810 1820 1830 1840 1850
LEFCKIEDQA ARHLAANLTL FPALEKLLLS GNLLGDEVAA ELAQVLPQMG
1860 1870 1880 1890 1900
QLKKVNLEWN RITARGAQLL AQGLVQGSCV PVIRLWNNPI LNDVAQSLQS
1910
QEPRLDFSIT DQQTL
Length:1,915
Mass (Da):211,710
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i731919C80F353C1F
GO
Isoform 2 (identifier: C3VPR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1384-1392: LEEPWVDSV → YLPALGRRV
     1393-1915: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:1,392
Mass (Da):154,279
Checksum:i9C778B0056FD1050
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLX4A0A1D5RLX4_MOUSE
Protein NLRC5
Nlrc5
1,393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3U1H4Q3U1H4_MOUSE
Protein NLRC5
Nlrc5 AI451557
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1C5S4R1C5_MOUSE
Protein NLRC5
Nlrc5
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti489 – 490SF → AS in BAD90135 (PubMed:12465718).Curated2
Sequence conflicti578M → T in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti641R → C in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti646N → K in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti833V → I in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti881G → R in ACP40992 (PubMed:20434986).Curated1
Sequence conflicti896A → T in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti939N → S in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti1105R → Q in BAD90135 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0397021384 – 1392LEEPWVDSV → YLPALGRRV in isoform 2. 1 Publication9
Alternative sequenceiVSP_0397031393 – 1915Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ889356 mRNA Translation: ACP40992.1
AK220210 mRNA Translation: BAD90135.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59741.1 [C3VPR6-1]

NCBI Reference Sequences

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RefSeqi
NP_001028379.2, NM_001033207.3 [C3VPR6-1]
XP_006531225.1, XM_006531162.2 [C3VPR6-1]
XP_006531226.1, XM_006531163.2 [C3VPR6-1]
XP_011246730.1, XM_011248428.1 [C3VPR6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.334720

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000053085; ENSMUSP00000138322; ENSMUSG00000074151 [C3VPR6-1]
ENSMUST00000211816; ENSMUSP00000148677; ENSMUSG00000074151 [C3VPR6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
434341

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:434341

UCSC genome browser

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UCSCi
uc009mwj.2 mouse [C3VPR6-2]
uc012gio.1 mouse [C3VPR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ889356 mRNA Translation: ACP40992.1
AK220210 mRNA Translation: BAD90135.1
CCDSiCCDS59741.1 [C3VPR6-1]
RefSeqiNP_001028379.2, NM_001033207.3 [C3VPR6-1]
XP_006531225.1, XM_006531162.2 [C3VPR6-1]
XP_006531226.1, XM_006531163.2 [C3VPR6-1]
XP_011246730.1, XM_011248428.1 [C3VPR6-1]
UniGeneiMm.334720

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJMNMR-A1-96[»]
ProteinModelPortaliC3VPR6
SMRiC3VPR6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC3VPR6, 2 interactors

PTM databases

iPTMnetiC3VPR6
PhosphoSitePlusiC3VPR6

Proteomic databases

EPDiC3VPR6
MaxQBiC3VPR6
PeptideAtlasiC3VPR6
PRIDEiC3VPR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053085; ENSMUSP00000138322; ENSMUSG00000074151 [C3VPR6-1]
ENSMUST00000211816; ENSMUSP00000148677; ENSMUSG00000074151 [C3VPR6-1]
GeneIDi434341
KEGGimmu:434341
UCSCiuc009mwj.2 mouse [C3VPR6-2]
uc012gio.1 mouse [C3VPR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84166
MGIiMGI:3612191 Nlrc5

Phylogenomic databases

GeneTreeiENSGT00940000160652
HOGENOMiHOG000168392
HOVERGENiHBG108194
InParanoidiC3VPR6
KOiK22615
OMAiCHCVGET
OrthoDBi19417at2759
PhylomeDBiC3VPR6

Miscellaneous databases

Protein Ontology

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PROi
PR:C3VPR6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000074151 Expressed in 86 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiC3VPR6 baseline and differential
GenevisibleiC3VPR6 MM

Family and domain databases

Gene3Di3.80.10.10, 8 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 7 hits
PF05729 NACHT, 1 hit
SMARTiView protein in SMART
SM00367 LRR_CC, 13 hits
SM00369 LRR_TYP, 9 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837 NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLRC5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3VPR6
Secondary accession number(s): Q571H9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: January 16, 2019
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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