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UniProtKB - C3V005 (C3V005_9FLAV)

Entry version 98 (07 Apr 2021)
Sequence version 1 (16 Jun 2009)
Previous versions | rss
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Protein

Core protein

Gene
N/A
Organism
Chimeric Tick-borne encephalitis virus/Dengue virus 4
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.ARBA annotation
Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1530Charge relay system; for serine protease NS3 activityUniRule annotation1
Active sitei1554Charge relay system; for serine protease NS3 activityUniRule annotation1
Active sitei1614Charge relay system; for serine protease NS3 activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2548S-adenosyl-L-methionineUniRule annotation1
Binding sitei2578S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2579S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2596S-adenosyl-L-methionineUniRule annotation1
Binding sitei2597S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2623S-adenosyl-L-methionineUniRule annotation1
Binding sitei2624S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2711S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2930Zinc 1UniRule annotation1
Metal bindingi2934Zinc 1; via tele nitrogenUniRule annotation1
Metal bindingi2939Zinc 1UniRule annotation1
Metal bindingi2942Zinc 1UniRule annotation1
Metal bindingi3205Zinc 2; via tele nitrogenUniRule annotation1
Metal bindingi3221Zinc 2UniRule annotation1
Metal bindingi3340Zinc 2UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Serine proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Fusion of virus membrane with host endosomal membraneARBA annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT2 by virusARBA annotation, mRNA cappingARBA annotation, mRNA processing, Viral attachment to host cellARBA annotation, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replicationARBA annotation, Virus entry into host cell
LigandATP-binding, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding, S-adenosyl-L-methionineARBA annotation, ZincUniRule annotation

Protein family/group databases

MEROPS protease database

More...MEROPSi		S07.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core proteinARBA annotation (EC:3.4.21.91ARBA annotation, EC:3.6.1.15ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Envelope protein EARBA annotation
Flavivirin protease NS2B regulatory subunitARBA annotation
Flavivirin protease NS3 catalytic subunitARBA annotation
Genome polyproteinARBA annotation
Matrix proteinARBA annotation
Non-structural protein 1ARBA annotation
Non-structural protein 2AARBA annotation
Non-structural protein 2BARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4AARBA annotation
Non-structural protein 4BARBA annotation
Peptide 2kARBA annotation
Peptide prARBA annotation
Protein prMARBA annotation
RNA-directed RNA polymerase NS5ARBA annotation
Serine protease NS3ARBA annotation
Serine protease subunit NS2BARBA annotation
Small envelope protein MARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChimeric Tick-borne encephalitis virus/Dengue virus 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri638787 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Kitrinoviricota › Flasuviricetes › Amarillovirales › Flaviviridae › Flavivirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000163390 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 122HelicalSequence analysisAdd BLAST19
Transmembranei731 – 752HelicalSequence analysisAdd BLAST22
Transmembranei1162 – 1182HelicalSequence analysisAdd BLAST21
Transmembranei1202 – 1223HelicalSequence analysisAdd BLAST22
Transmembranei1291 – 1310HelicalSequence analysisAdd BLAST20
Transmembranei1322 – 1341HelicalSequence analysisAdd BLAST20
Transmembranei1446 – 1473HelicalSequence analysisAdd BLAST28
Transmembranei2152 – 2170HelicalSequence analysisAdd BLAST19
Transmembranei2177 – 2195HelicalSequence analysisAdd BLAST19
Transmembranei2201 – 2218HelicalSequence analysisAdd BLAST18
Transmembranei2230 – 2247HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Capsid proteinARBA annotation, Host endoplasmic reticulumPROSITE-ProRule annotationARBA annotation, Host membranePROSITE-ProRule annotationARBA annotation, Host nucleusARBA annotation, Membrane, SecretedARBA annotation, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 313UniRule annotationCombined sources
Disulfide bondi343 ↔ 404Combined sources
Disulfide bondi343 ↔ 399UniRule annotation
Disulfide bondi357 ↔ 388UniRule annotationCombined sources
Disulfide bondi375 ↔ 404UniRule annotation
Disulfide bondi375 ↔ 399Combined sources
Disulfide bondi469 ↔ 573UniRule annotationCombined sources
Disulfide bondi590 ↔ 621UniRule annotationCombined sources

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		C3V005

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		C3V005

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1350 – 1479FLAVIVIRUS_NS2BInterPro annotationAdd BLAST130
Domaini1480 – 1657Peptidase S7InterPro annotationAdd BLAST178
Domaini1659 – 1815Helicase ATP-bindingInterPro annotationAdd BLAST157
Domaini1810 – 1991Helicase C-terminalInterPro annotationAdd BLAST182
Domaini2494 – 2756MRNA cap 0-1 NS5-type MTInterPro annotationAdd BLAST263
Domaini3020 – 3170RdRp catalyticInterPro annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1402 – 1441Interacts with and activates NS3 proteasePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helixPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd20761, capping_2-OMTase_Flaviviridae, 1 hit
cd12149, Flavi_E_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.930, 1 hit
1.10.8.970, 1 hit
1.20.1280.260, 1 hit
2.40.10.10, 1 hit
2.60.260.50, 1 hit
2.60.40.350, 1 hit
2.60.98.10, 1 hit
3.30.387.10, 1 hit
3.30.67.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR038302, Env_glycoprot_M_sf_flavivir
IPR013755, Flav_gly_cen_dom_subdom1
IPR001122, Flavi_capsidC
IPR037172, Flavi_capsidC_sf
IPR027287, Flavi_E_Ig-like
IPR026470, Flavi_E_Stem/Anchor_dom
IPR038345, Flavi_E_Stem/Anchor_dom_sf
IPR001157, Flavi_NS1
IPR000752, Flavi_NS2A
IPR000487, Flavi_NS2B
IPR000404, Flavi_NS4A
IPR001528, Flavi_NS4B
IPR002535, Flavi_propep
IPR038688, Flavi_propep_sf
IPR000336, Flavivir/Alphavir_Ig-like_sf
IPR001850, Flavivirus_NS3_S7
IPR014412, Gen_Poly_FLV
IPR011998, Glycoprot_cen/dimer
IPR036253, Glycoprot_cen/dimer_sf
IPR038055, Glycoprot_E_dimer_dom
IPR013756, GlyE_cen_dom_subdom2
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR026490, mRNA_cap_0/1_MeTrfase
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000208, RNA-dir_pol_flavivirus
IPR007094, RNA-dir_pol_PSvirus
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01003, Flavi_capsid, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF02832, Flavi_glycop_C, 1 hit
PF00869, Flavi_glycoprot, 1 hit
PF00948, Flavi_NS1, 1 hit
PF01005, Flavi_NS2A, 1 hit
PF01002, Flavi_NS2B, 1 hit
PF01350, Flavi_NS4A, 1 hit
PF01349, Flavi_NS4B, 1 hit
PF00972, Flavi_NS5, 1 hit
PF01570, Flavi_propep, 1 hit
PF01728, FtsJ, 1 hit
PF00949, Peptidase_S7, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003817, Gen_Poly_FLV, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101257, SSF101257, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
SSF56983, SSF56983, 1 hit
SSF81296, SSF81296, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04240, flavi_E_stem, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51527, FLAVIVIRUS_NS2B, 1 hit
PS51528, FLAVIVIRUS_NS3PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51591, RNA_CAP01_NS5_MT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3V005-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI 
        60         70         80         90        100
TFLRVLSIPP TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS 
       110        120        130        140        150
AVDWTGWLLV VVLLGVTLAA TVRKERDGTT VIRAEGKDAA TQVRVENGTC 
       160        170        180        190        200
VILATDMGSW CDDSLTYECV TIDQGEEPVD VDCFCRNVDG VYLEYGRCGK 
       210        220        230        240        250
QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV EGWVWKNKVL 
       260        270        280        290        300
TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG 
       310        320        330        340        350
TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD 
       360        370        380        390        400
TKVAARCPTM GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV 
       410        420        430        440        450
KASCEAKKKA TGHVYDANKI VYTVKVEPHT GDYVAANETH SGRKTASFTV 
       460        470        480        490        500
SSERTILTMG DYGDVSLLCR VASGVDLAQT VILELDKTSE HLPTAWQVHR 
       510        520        530        540        550
DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL GDQTGVLLKS 
       560        570        580        590        600
LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI 
       610        620        630        640        650
PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN 
       660        670        680        690        700
GGGFIEMQLP PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG 
       710        720        730        740        750
EHAWDFGSTG GFLTSVGKAL HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL 
       760        770        780        790        800
GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD MGCVASWSGK ELKCGSGIFV 
       810        820        830        840        850
VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT RLENVMWKQI 
       860        870        880        890        900
TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA 
       910        920        930        940        950
KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF 
       960        970        980        990       1000
REGSSEVCDH RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK 
      1010       1020       1030       1040       1050
TCLWPKTHTL WSNGVLESQM LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG 
      1060       1070       1080       1090       1100
KLEIDFGECP GTTVTIQEDC DHRGPSLRTT TASGKLVTQW CCRSCTMPPL 
      1110       1120       1130       1140       1150
RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS MGLLCLTLFV 
      1160       1170       1180       1190       1200
EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG 
      1210       1220       1230       1240       1250
GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL 
      1260       1270       1280       1290       1300
MELIDGISLG LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA 
      1310       1320       1330       1340       1350
VLFVVTLIPL CRTSCLQKQS HWVEITALIL GAQALPVYLM TLMKGASRRS 
      1360       1370       1380       1390       1400
WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP MVAGGLLLAA YVMSGSSADL 
      1410       1420       1430       1440       1450
SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE TNMITLLVKL 
      1460       1470       1480       1490       1500
ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG 
      1510       1520       1530       1540       1550
VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD 
      1560       1570       1580       1590       1600
VRNDMISYGG GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG 
      1610       1620       1630       1640       1650
EIGAVTLDFK PGTSGSPIIN RKGKVIGLYG NGVVTKSGDY VSAITQAERI 
      1660       1670       1680       1690       1700
GEPDYEVDED IFRKKRLTIM DLHPGAGKTK RILPSIVREA LKRRLRTLIL 
      1710       1720       1730       1740       1750
APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC HATFTTRLLS 
      1760       1770       1780       1790       1800
STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA 
      1810       1820       1830       1840       1850
TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI 
      1860       1870       1880       1890       1900
ANCLRKSGKK VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR 
      1910       1920       1930       1940       1950
VIDPRRCLKP VILPDGPERV ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ 
      1960       1970       1980       1990       2000
YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP EGIIPTLFGP EREKTQAIDG 
      2010       2020       2030       2040       2050
EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE WCFTGERNNQ 
      2060       2070       2080       2090       2100
ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT 
      2110       2120       2130       2140       2150
LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE 
      2160       2170       2180       2190       2200
TLMLVALLGA MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ 
      2210       2220       2230       2240       2250
WIAASIILEF FLMVLLIPEP EKQRTPQDNQ LIYVILTILT IIGLIAANEM 
      2260       2270       2280       2290       2300
GLIEKTKTDF GFYQVKTETT ILDVDLRPAS AWTLYAVATT ILTPMLRHTI 
      2310       2320       2330       2340       2350
ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM GCYSQVNPTT 
      2360       2370       2380       2390       2400
LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE 
      2410       2420       2430       2440       2450
PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE 
      2460       2470       2480       2490       2500
GNPGRFWNTT IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET 
      2510       2520       2530       2540       2550
LGEKWKRQLN SLDRKEFEEY KRSGILEVDR TEAKSALKDG SKIKHAVSRG 
      2560       2570       2580       2590       2600
SSKIRWIVER GMVKPKGKVV DLGCGRGGWS YYMATLKNVT EVKGYTKGGP 
      2610       2620       2630       2640       2650
GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG ESSSNPTIEE 
      2660       2670       2680       2690       2700
GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC 
      2710       2720       2730       2740       2750
PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL 
      2760       2770       2780       2790       2800
GAGTRSVSTE TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS 
      2810       2820       2830       2840       2850
YEAPSTGSAS SMVNGVVKLL TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK 
      2860       2870       2880       2890       2900
VDTRTPQPKP GTRMVMTTTA NWLWALLGKK KNPRLCTREE FISKVRSNAA 
      2910       2920       2930       2940       2950
IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE SCVYNMMGKR 
      2960       2970       2980       2990       3000
EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE 
      3010       3020       3030       3040       3050
GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA 
      3060       3070       3080       3090       3100
PHHKILAKAI FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG 
      3110       3120       3130       3140       3150
LNTFTNMEVQ LIRQMEAEGV ITQDDMQNPK GLKERVEKWL KECGVDRLKR 
      3160       3170       3180       3190       3200
MAISGDDCVV KPLDERFGTS LLFLNDMGKV RKDIPQWEPS KGWKNWQEVP 
      3210       3220       3230       3240       3250
FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS LRETACLGKA 
      3260       3270       3280       3290       3300
YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE 
      3310       3320       3330       3340       3350
DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA 
      3360       3370       3380       3390 
TWAKNIHTAI TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL
Length:3,392
Mass (Da):378,138
Last modified:June 16, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C7C70F2A34E4418
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ828987 Other RNA Translation: ACO82049.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ828987 Other RNA Translation: ACO82049.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K4Relectron microscopy24.00A/B/C284-678[»]
SMRiC3V005
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

MEROPSiS07.001

Miscellaneous databases

EvolutionaryTraceiC3V005

Family and domain databases

CDDicd20761, capping_2-OMTase_Flaviviridae, 1 hit
cd12149, Flavi_E_C, 1 hit
Gene3Di1.10.10.930, 1 hit
1.10.8.970, 1 hit
1.20.1280.260, 1 hit
2.40.10.10, 1 hit
2.60.260.50, 1 hit
2.60.40.350, 1 hit
2.60.98.10, 1 hit
3.30.387.10, 1 hit
3.30.67.10, 1 hit
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR038302, Env_glycoprot_M_sf_flavivir
IPR013755, Flav_gly_cen_dom_subdom1
IPR001122, Flavi_capsidC
IPR037172, Flavi_capsidC_sf
IPR027287, Flavi_E_Ig-like
IPR026470, Flavi_E_Stem/Anchor_dom
IPR038345, Flavi_E_Stem/Anchor_dom_sf
IPR001157, Flavi_NS1
IPR000752, Flavi_NS2A
IPR000487, Flavi_NS2B
IPR000404, Flavi_NS4A
IPR001528, Flavi_NS4B
IPR002535, Flavi_propep
IPR038688, Flavi_propep_sf
IPR000336, Flavivir/Alphavir_Ig-like_sf
IPR001850, Flavivirus_NS3_S7
IPR014412, Gen_Poly_FLV
IPR011998, Glycoprot_cen/dimer
IPR036253, Glycoprot_cen/dimer_sf
IPR038055, Glycoprot_E_dimer_dom
IPR013756, GlyE_cen_dom_subdom2
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR026490, mRNA_cap_0/1_MeTrfase
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000208, RNA-dir_pol_flavivirus
IPR007094, RNA-dir_pol_PSvirus
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01003, Flavi_capsid, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF02832, Flavi_glycop_C, 1 hit
PF00869, Flavi_glycoprot, 1 hit
PF00948, Flavi_NS1, 1 hit
PF01005, Flavi_NS2A, 1 hit
PF01002, Flavi_NS2B, 1 hit
PF01350, Flavi_NS4A, 1 hit
PF01349, Flavi_NS4B, 1 hit
PF00972, Flavi_NS5, 1 hit
PF01570, Flavi_propep, 1 hit
PF01728, FtsJ, 1 hit
PF00949, Peptidase_S7, 1 hit
PIRSFiPIRSF003817, Gen_Poly_FLV, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF101257, SSF101257, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
SSF56983, SSF56983, 1 hit
SSF81296, SSF81296, 1 hit
TIGRFAMsiTIGR04240, flavi_E_stem, 1 hit
PROSITEiView protein in PROSITE
PS51527, FLAVIVIRUS_NS2B, 1 hit
PS51528, FLAVIVIRUS_NS3PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51591, RNA_CAP01_NS5_MT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3V005_9FLAV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3V005
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 7, 2021
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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