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Entry version 97 (02 Dec 2020)
Sequence version 1 (16 Jun 2009)
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Protein

Core protein

Gene
N/A
Organism
Chimeric Tick-borne encephalitis virus/Dengue virus 4
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.ARBA annotation
Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1530Charge relay system; for serine protease NS3 activityUniRule annotation1
Active sitei1554Charge relay system; for serine protease NS3 activityUniRule annotation1
Active sitei1614Charge relay system; for serine protease NS3 activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2548S-adenosyl-L-methionineUniRule annotation1
Binding sitei2578S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2579S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2596S-adenosyl-L-methionineUniRule annotation1
Binding sitei2597S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2623S-adenosyl-L-methionineUniRule annotation1
Binding sitei2624S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei2711S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2930Zinc 1UniRule annotation1
Metal bindingi2934Zinc 1; via tele nitrogenUniRule annotation1
Metal bindingi2939Zinc 1UniRule annotation1
Metal bindingi2942Zinc 1UniRule annotation1
Metal bindingi3205Zinc 2; via tele nitrogenUniRule annotation1
Metal bindingi3221Zinc 2UniRule annotation1
Metal bindingi3340Zinc 2UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Serine proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Fusion of virus membrane with host endosomal membraneARBA annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT2 by virusARBA annotation, mRNA cappingARBA annotation, mRNA processing, Viral attachment to host cellARBA annotation, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replicationARBA annotation, Virus entry into host cell
LigandATP-binding, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding, S-adenosyl-L-methionineARBA annotation, ZincUniRule annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S07.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core proteinARBA annotation (EC:3.4.21.91ARBA annotation, EC:3.6.1.15ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Envelope protein EARBA annotation
Flavivirin protease NS2B regulatory subunitARBA annotation
Flavivirin protease NS3 catalytic subunitARBA annotation
Genome polyproteinARBA annotation
Matrix proteinARBA annotation
Non-structural protein 1ARBA annotation
Non-structural protein 2AARBA annotation
Non-structural protein 2BARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4AARBA annotation
Non-structural protein 4BARBA annotation
Peptide 2kARBA annotation
Peptide prARBA annotation
Protein prMARBA annotation
RNA-directed RNA polymerase NS5ARBA annotation
Serine protease NS3ARBA annotation
Serine protease subunit NS2BARBA annotation
Small envelope protein MARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChimeric Tick-borne encephalitis virus/Dengue virus 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri638787 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaFlasuviricetesAmarilloviralesFlaviviridaeFlavivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000163390 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei104 – 122HelicalSequence analysisAdd BLAST19
Transmembranei731 – 752HelicalSequence analysisAdd BLAST22
Transmembranei1162 – 1182HelicalSequence analysisAdd BLAST21
Transmembranei1202 – 1223HelicalSequence analysisAdd BLAST22
Transmembranei1291 – 1310HelicalSequence analysisAdd BLAST20
Transmembranei1322 – 1341HelicalSequence analysisAdd BLAST20
Transmembranei1446 – 1473HelicalSequence analysisAdd BLAST28
Transmembranei2152 – 2170HelicalSequence analysisAdd BLAST19
Transmembranei2177 – 2195HelicalSequence analysisAdd BLAST19
Transmembranei2201 – 2218HelicalSequence analysisAdd BLAST18
Transmembranei2230 – 2247HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinARBA annotation, Host endoplasmic reticulumPROSITE-ProRule annotationARBA annotation, Host membranePROSITE-ProRule annotationARBA annotation, Host nucleusARBA annotation, Membrane, SecretedARBA annotation, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 313UniRule annotationCombined sources
Disulfide bondi343 ↔ 404Combined sources
Disulfide bondi343 ↔ 399UniRule annotation
Disulfide bondi357 ↔ 388UniRule annotationCombined sources
Disulfide bondi375 ↔ 404UniRule annotation
Disulfide bondi375 ↔ 399Combined sources
Disulfide bondi469 ↔ 573UniRule annotationCombined sources
Disulfide bondi590 ↔ 621UniRule annotationCombined sources

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C3V005

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
C3V005

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1350 – 1479FLAVIVIRUS_NS2BInterPro annotationAdd BLAST130
Domaini1480 – 1657Peptidase S7InterPro annotationAdd BLAST178
Domaini1659 – 1815Helicase ATP-bindingInterPro annotationAdd BLAST157
Domaini1810 – 1991Helicase C-terminalInterPro annotationAdd BLAST182
Domaini2494 – 2756MRNA cap 0-1 NS5-type MTInterPro annotationAdd BLAST263
Domaini3020 – 3170RdRp catalyticInterPro annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1402 – 1441Interacts with and activates NS3 proteasePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helixPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12149, Flavi_E_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.930, 1 hit
1.10.8.970, 1 hit
1.20.1280.260, 1 hit
2.40.10.10, 1 hit
2.60.260.50, 1 hit
2.60.40.350, 1 hit
2.60.98.10, 1 hit
3.30.387.10, 1 hit
3.30.67.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR038302, Env_glycoprot_M_sf_flavivir
IPR013755, Flav_gly_cen_dom_subdom1
IPR001122, Flavi_capsidC
IPR037172, Flavi_capsidC_sf
IPR027287, Flavi_E_Ig-like
IPR026470, Flavi_E_Stem/Anchor_dom
IPR038345, Flavi_E_Stem/Anchor_dom_sf
IPR001157, Flavi_NS1
IPR000752, Flavi_NS2A
IPR000487, Flavi_NS2B
IPR000404, Flavi_NS4A
IPR001528, Flavi_NS4B
IPR002535, Flavi_propep
IPR038688, Flavi_propep_sf
IPR000336, Flavivir/Alphavir_Ig-like_sf
IPR001850, Flavivirus_NS3_S7
IPR014412, Gen_Poly_FLV
IPR011998, Glycoprot_cen/dimer
IPR036253, Glycoprot_cen/dimer_sf
IPR038055, Glycoprot_E_dimer_dom
IPR013756, GlyE_cen_dom_subdom2
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR026490, mRNA_cap_0/1_MeTrfase
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000208, RNA-dir_pol_flavivirus
IPR007094, RNA-dir_pol_PSvirus
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01003, Flavi_capsid, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF02832, Flavi_glycop_C, 1 hit
PF00869, Flavi_glycoprot, 1 hit
PF00948, Flavi_NS1, 1 hit
PF01005, Flavi_NS2A, 1 hit
PF01002, Flavi_NS2B, 1 hit
PF01350, Flavi_NS4A, 1 hit
PF01349, Flavi_NS4B, 1 hit
PF00972, Flavi_NS5, 1 hit
PF01570, Flavi_propep, 1 hit
PF01728, FtsJ, 1 hit
PF00949, Peptidase_S7, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003817, Gen_Poly_FLV, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101257, SSF101257, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
SSF56983, SSF56983, 1 hit
SSF81296, SSF81296, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04240, flavi_E_stem, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51527, FLAVIVIRUS_NS2B, 1 hit
PS51528, FLAVIVIRUS_NS3PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51591, RNA_CAP01_NS5_MT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3V005-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI
60 70 80 90 100
TFLRVLSIPP TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS
110 120 130 140 150
AVDWTGWLLV VVLLGVTLAA TVRKERDGTT VIRAEGKDAA TQVRVENGTC
160 170 180 190 200
VILATDMGSW CDDSLTYECV TIDQGEEPVD VDCFCRNVDG VYLEYGRCGK
210 220 230 240 250
QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV EGWVWKNKVL
260 270 280 290 300
TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG
310 320 330 340 350
TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD
360 370 380 390 400
TKVAARCPTM GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV
410 420 430 440 450
KASCEAKKKA TGHVYDANKI VYTVKVEPHT GDYVAANETH SGRKTASFTV
460 470 480 490 500
SSERTILTMG DYGDVSLLCR VASGVDLAQT VILELDKTSE HLPTAWQVHR
510 520 530 540 550
DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL GDQTGVLLKS
560 570 580 590 600
LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI
610 620 630 640 650
PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN
660 670 680 690 700
GGGFIEMQLP PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG
710 720 730 740 750
EHAWDFGSTG GFLTSVGKAL HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL
760 770 780 790 800
GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD MGCVASWSGK ELKCGSGIFV
810 820 830 840 850
VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT RLENVMWKQI
860 870 880 890 900
TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA
910 920 930 940 950
KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF
960 970 980 990 1000
REGSSEVCDH RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK
1010 1020 1030 1040 1050
TCLWPKTHTL WSNGVLESQM LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG
1060 1070 1080 1090 1100
KLEIDFGECP GTTVTIQEDC DHRGPSLRTT TASGKLVTQW CCRSCTMPPL
1110 1120 1130 1140 1150
RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS MGLLCLTLFV
1160 1170 1180 1190 1200
EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG
1210 1220 1230 1240 1250
GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL
1260 1270 1280 1290 1300
MELIDGISLG LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA
1310 1320 1330 1340 1350
VLFVVTLIPL CRTSCLQKQS HWVEITALIL GAQALPVYLM TLMKGASRRS
1360 1370 1380 1390 1400
WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP MVAGGLLLAA YVMSGSSADL
1410 1420 1430 1440 1450
SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE TNMITLLVKL
1460 1470 1480 1490 1500
ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG
1510 1520 1530 1540 1550
VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD
1560 1570 1580 1590 1600
VRNDMISYGG GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG
1610 1620 1630 1640 1650
EIGAVTLDFK PGTSGSPIIN RKGKVIGLYG NGVVTKSGDY VSAITQAERI
1660 1670 1680 1690 1700
GEPDYEVDED IFRKKRLTIM DLHPGAGKTK RILPSIVREA LKRRLRTLIL
1710 1720 1730 1740 1750
APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC HATFTTRLLS
1760 1770 1780 1790 1800
STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA
1810 1820 1830 1840 1850
TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI
1860 1870 1880 1890 1900
ANCLRKSGKK VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR
1910 1920 1930 1940 1950
VIDPRRCLKP VILPDGPERV ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ
1960 1970 1980 1990 2000
YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP EGIIPTLFGP EREKTQAIDG
2010 2020 2030 2040 2050
EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE WCFTGERNNQ
2060 2070 2080 2090 2100
ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT
2110 2120 2130 2140 2150
LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE
2160 2170 2180 2190 2200
TLMLVALLGA MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ
2210 2220 2230 2240 2250
WIAASIILEF FLMVLLIPEP EKQRTPQDNQ LIYVILTILT IIGLIAANEM
2260 2270 2280 2290 2300
GLIEKTKTDF GFYQVKTETT ILDVDLRPAS AWTLYAVATT ILTPMLRHTI
2310 2320 2330 2340 2350
ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM GCYSQVNPTT
2360 2370 2380 2390 2400
LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE
2410 2420 2430 2440 2450
PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE
2460 2470 2480 2490 2500
GNPGRFWNTT IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET
2510 2520 2530 2540 2550
LGEKWKRQLN SLDRKEFEEY KRSGILEVDR TEAKSALKDG SKIKHAVSRG
2560 2570 2580 2590 2600
SSKIRWIVER GMVKPKGKVV DLGCGRGGWS YYMATLKNVT EVKGYTKGGP
2610 2620 2630 2640 2650
GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG ESSSNPTIEE
2660 2670 2680 2690 2700
GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC
2710 2720 2730 2740 2750
PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL
2760 2770 2780 2790 2800
GAGTRSVSTE TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS
2810 2820 2830 2840 2850
YEAPSTGSAS SMVNGVVKLL TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK
2860 2870 2880 2890 2900
VDTRTPQPKP GTRMVMTTTA NWLWALLGKK KNPRLCTREE FISKVRSNAA
2910 2920 2930 2940 2950
IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE SCVYNMMGKR
2960 2970 2980 2990 3000
EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE
3010 3020 3030 3040 3050
GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA
3060 3070 3080 3090 3100
PHHKILAKAI FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG
3110 3120 3130 3140 3150
LNTFTNMEVQ LIRQMEAEGV ITQDDMQNPK GLKERVEKWL KECGVDRLKR
3160 3170 3180 3190 3200
MAISGDDCVV KPLDERFGTS LLFLNDMGKV RKDIPQWEPS KGWKNWQEVP
3210 3220 3230 3240 3250
FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS LRETACLGKA
3260 3270 3280 3290 3300
YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE
3310 3320 3330 3340 3350
DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA
3360 3370 3380 3390
TWAKNIHTAI TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL
Length:3,392
Mass (Da):378,138
Last modified:June 16, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C7C70F2A34E4418
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FJ828987 Other RNA Translation: ACO82049.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ828987 Other RNA Translation: ACO82049.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K4Relectron microscopy24.00A/B/C284-678[»]
SMRiC3V005
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

MEROPSiS07.001

Miscellaneous databases

EvolutionaryTraceiC3V005

Family and domain databases

CDDicd12149, Flavi_E_C, 1 hit
Gene3Di1.10.10.930, 1 hit
1.10.8.970, 1 hit
1.20.1280.260, 1 hit
2.40.10.10, 1 hit
2.60.260.50, 1 hit
2.60.40.350, 1 hit
2.60.98.10, 1 hit
3.30.387.10, 1 hit
3.30.67.10, 1 hit
InterProiView protein in InterPro
IPR011492, DEAD_Flavivir
IPR043502, DNA/RNA_pol_sf
IPR038302, Env_glycoprot_M_sf_flavivir
IPR013755, Flav_gly_cen_dom_subdom1
IPR001122, Flavi_capsidC
IPR037172, Flavi_capsidC_sf
IPR027287, Flavi_E_Ig-like
IPR026470, Flavi_E_Stem/Anchor_dom
IPR038345, Flavi_E_Stem/Anchor_dom_sf
IPR001157, Flavi_NS1
IPR000752, Flavi_NS2A
IPR000487, Flavi_NS2B
IPR000404, Flavi_NS4A
IPR001528, Flavi_NS4B
IPR002535, Flavi_propep
IPR038688, Flavi_propep_sf
IPR000336, Flavivir/Alphavir_Ig-like_sf
IPR001850, Flavivirus_NS3_S7
IPR014412, Gen_Poly_FLV
IPR011998, Glycoprot_cen/dimer
IPR036253, Glycoprot_cen/dimer_sf
IPR038055, Glycoprot_E_dimer_dom
IPR013756, GlyE_cen_dom_subdom2
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR026490, mRNA_cap_0/1_MeTrfase
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000208, RNA-dir_pol_flavivirus
IPR007094, RNA-dir_pol_PSvirus
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01003, Flavi_capsid, 1 hit
PF07652, Flavi_DEAD, 1 hit
PF02832, Flavi_glycop_C, 1 hit
PF00869, Flavi_glycoprot, 1 hit
PF00948, Flavi_NS1, 1 hit
PF01005, Flavi_NS2A, 1 hit
PF01002, Flavi_NS2B, 1 hit
PF01350, Flavi_NS4A, 1 hit
PF01349, Flavi_NS4B, 1 hit
PF00972, Flavi_NS5, 1 hit
PF01570, Flavi_propep, 1 hit
PF01728, FtsJ, 1 hit
PF00949, Peptidase_S7, 1 hit
PIRSFiPIRSF003817, Gen_Poly_FLV, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF101257, SSF101257, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
SSF56983, SSF56983, 1 hit
SSF81296, SSF81296, 1 hit
TIGRFAMsiTIGR04240, flavi_E_stem, 1 hit
PROSITEiView protein in PROSITE
PS51527, FLAVIVIRUS_NS2B, 1 hit
PS51528, FLAVIVIRUS_NS3PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit
PS51591, RNA_CAP01_NS5_MT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3V005_9FLAV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3V005
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: December 2, 2020
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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