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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL), Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (A8G17_29450), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylamino-inidazol (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (BXT93_09180), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylformylglycinamidine cyclo-ligase (purM), Phosphoribosylaminoimidazole synthetase (purM), Phosphoribosylaminoimidazole synthetase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationSAAS annotation (EC:6.3.3.1UniRule annotationSAAS annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotationImported
ORF Names:A8G17_10865Imported, ARC77_08765Imported, AU473_09495Imported, BTQ04_12285Imported, BWP17_09500Imported, C7U73_04080Imported, CVH05_18305Imported, ECs3361Imported, ERS085383_02085Imported, ERS085404_01109Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000240660 Componenti: Unassembled WGS sequence
  • UP000043139 Componenti: Unassembled WGS sequence
  • UP000218692 Componenti: Unassembled WGS sequence
  • UP000044658 Componenti: Unassembled WGS sequence
  • UP000196865 Componenti: Unassembled WGS sequence
  • UP000188999 Componenti: Unassembled WGS sequence
  • UP000177471 Componenti: Chromosome
  • UP000231208 Componenti: Unassembled WGS sequence
  • UP000076266 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 164AIRSInterPro annotationAdd BLAST106
Domaini177 – 341AIRS_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229091

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

C3T042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKTSLSYK DAGVDIDAGN ALVGRIKGVV KKTRRPEVMG GLGGFGALCA
60 70 80 90 100
LPQKYREPVL VSGTDGVGTK LRLAMDLKRH DTIGIDLVAM CVNDLVVQGA
110 120 130 140 150
EPLFFLDYYA TGKLDVDTAS AVISGIAEGC LQSGCSLVGG ETAEMPGMYH
160 170 180 190 200
GEDYDVAGFC VGVVEKSEII DGSKVSDGDV LIALGSSGPH SNGYSLVRKI
210 220 230 240 250
LEVSGCDPQT TELDGKPLAD HLLAPTRIYV KSVLELIEKV DVNAIAHLTG
260 270 280 290 300
GGFWENIPRV LPDNTQAVID ESSWQWPEVF NWLQTAGNVE RHEMYRTFNC
310 320 330 340
GVGMIIALPA PEVDKALALL NANGENAWKI GIIKASDSEQ RVVIE
Length:345
Mass (Da):36,850
Last modified:June 16, 2009 - v1
Checksum:iC45B970C08661028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU897525 Genomic DNA Translation: ACI80076.1
EU897526 Genomic DNA Translation: ACI80077.1
EU897527 Genomic DNA Translation: ACI80078.1
EU897528 Genomic DNA Translation: ACI80079.1
EU897529 Genomic DNA Translation: ACI80080.1
CP015020 Genomic DNA Translation: AMW42330.1
CP017669 Genomic DNA Translation: APA41106.1
CYBJ01000009 Genomic DNA Translation: CTT76544.1
CYCH01000004 Genomic DNA Translation: CTU73753.1
MTFS01000010 Genomic DNA Translation: OOC81507.1
LYAA01001555 Genomic DNA Translation: OWC18154.1
MRVX01000034 Genomic DNA Translation: PAU14451.1
PGUD01000222 Genomic DNA Translation: PJG32215.1
PYPR01000005 Genomic DNA Translation: PSY22681.1
RefSeqiWP_001301832.1, NZ_PYPR01000005.1

Genome annotation databases

EnsemblBacteriaiAMW42330; AMW42330; ARC77_08765
CTT76544; CTT76544; ERS085383_02085
CTU73753; CTU73753; ERS085404_01109
OEG67676; OEG67676; A7H95_21490
PATRICifig|562.7073.peg.3665

Similar proteinsi

Entry informationi

Entry nameiC3T042_ECOLX
AccessioniPrimary (citable) accession number: C3T042
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 18, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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