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Entry version 88 (13 Nov 2019)
Sequence version 1 (16 Jun 2009)
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Protein

Multifunctional CCA protein

Gene

cca

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.UniRule annotationSAAS annotation

Miscellaneous

A single active site specifically recognizes both ATP and CTP and is responsible for their addition.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei8ATP or CTP; via amide nitrogenUniRule annotation1
Binding sitei11ATP or CTPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi21MagnesiumUniRule annotation1
Metal bindingi23MagnesiumUniRule annotation1
Binding sitei91ATP or CTPUniRule annotation1
Binding sitei137ATP or CTPUniRule annotation1
Binding sitei140ATP or CTPUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported, Multifunctional enzymeUniRule annotationSAAS annotation, NucleotidyltransferaseUniRule annotationSAAS annotationImported, RNA-bindingUniRule annotationSAAS annotation, Transferase
Biological processRNA repairUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, NickelUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001865295:AU473_RS06415-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multifunctional CCA proteinUniRule annotation
Including the following 4 domains:
CCA-adding enzymeUniRule annotation (EC:2.7.7.72UniRule annotation)
Alternative name(s):
CCA tRNA nucleotidyltransferaseUniRule annotation
tRNA CCA-pyrophosphorylaseUniRule annotation
tRNA adenylyl-/cytidylyl-transferaseUniRule annotation
tRNA nucleotidyltransferaseUniRule annotation
tRNA-NTUniRule annotation
2'-nucleotidaseUniRule annotation (EC:3.1.3.-UniRule annotation)
2',3'-cyclic phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
PhosphataseUniRule annotation (EC:3.1.3.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccaUniRule annotationImported
ORF Names:ARC77_11720Imported, AU473_06430Imported, BTQ04_03885Imported, BvCms35BK_02950Imported, BWP17_06615Imported, C9E67_04175Imported, CRE06_06105Imported, CVH05_25465Imported, D4M06_13735Imported, D7K63_18215Imported, D7K66_03820Imported, D9L89_04695Imported, D9X97_02445Imported, DAH26_15925Imported, DAH49_14610Imported, DL455_14695Imported, DMI04_03545Imported, DNB37_07935Imported, DOY56_09375Imported, DXX80_008905Imported, EB509_06025Imported, EB510_08115Imported, EB515_06350Imported, ECs3939Imported, ED225_03595Imported, ED607_04590Imported, ED611_03605Imported, ED903_02205Imported, ED944_06585Imported, EEA45_08250Imported, EF173_13505Imported, NCTC13127_01043Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000281995 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000282463 Componenti: Unassembled WGS sequence
  • UP000281625 Componenti: Unassembled WGS sequence
  • UP000281445 Componenti: Unassembled WGS sequence
  • UP000277856 Componenti: Unassembled WGS sequence
  • UP000231208 Componenti: Unassembled WGS sequence
  • UP000281718 Componenti: Unassembled WGS sequence
  • UP000282372 Componenti: Unassembled WGS sequence
  • UP000273320 Componenti: Unassembled WGS sequence
  • UP000298047 Componenti: Unassembled WGS sequence
  • UP000256361 Componenti: Unassembled WGS sequence
  • UP000282092 Componenti: Unassembled WGS sequence
  • UP000282530 Componenti: Unassembled WGS sequence
  • UP000177471 Componenti: Chromosome
  • UP000297363 Componenti: Unassembled WGS sequence
  • UP000254180 Componenti: Unassembled WGS sequence
  • UP000281456 Componenti: Unassembled WGS sequence
  • UP000281166 Componenti: Unassembled WGS sequence
  • UP000258250 Componenti: Unassembled WGS sequence
  • UP000281320 Componenti: Unassembled WGS sequence
  • UP000281795 Componenti: Unassembled WGS sequence
  • UP000076266 Componenti: Chromosome
  • UP000304105 Componenti: Unassembled WGS sequence
  • UP000281571 Componenti: Unassembled WGS sequence
  • UP000282233 Componenti: Unassembled WGS sequence
  • UP000282081 Componenti: Unassembled WGS sequence
  • UP000218692 Componenti: Unassembled WGS sequence
  • UP000298553 Componenti: Chromosome
  • UP000188999 Componenti: Unassembled WGS sequence
  • UP000282284 Componenti: Unassembled WGS sequence
  • UP000279027 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Can also form homodimers and oligomers.

UniRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 329HDInterPro annotationAdd BLAST102

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.UniRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D4J Bacteria
COG0617 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077 HDc, 1 hit
cd05398 NT_ClassII-CCAase, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01261 CCA_bact_type1, 1 hit
MF_01262 CCA_bact_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012006 CCA_bact
IPR003607 HD/PDEase_dom
IPR006674 HD_domain
IPR002646 PolA_pol_head_dom
IPR032828 PolyA_RNA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01966 HD, 1 hit
PF01743 PolyA_pol, 1 hit
PF12627 PolyA_pol_RNAbd, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000813 CCA_bact, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51831 HD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3SU43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIYLVGGAV RDALLGLPVK DRDWVVVGST PQEMLDAGYQ QVGRDFPVFL
60 70 80 90 100
HPQTHEEYAL ARTERKSGSG YTGFTCYAAP DVTLEDDLKR RDLTINALAQ
110 120 130 140 150
DDNGEIIDPY NGLGDLQNRL LRHVSPAFGE DPLRVLRVAR FAARYAHLGF
160 170 180 190 200
RIADETLTLM REMTHAGELE HLTPERVWKE TENALTTRNP QVFFQVLRDC
210 220 230 240 250
GALRVLFPEI DALFGVPAPA RWHPEIDTGI HTLMTLSMAA MLSPQVDVRF
260 270 280 290 300
TTLCHDLGKG LTPPELWPRH HGHGPAGVKL VEQLCQRLRV PNEIRDLARL
310 320 330 340 350
VAEFHDLIHT FPMLNPKTIV KLFDSIDAWR KPQRVEQLAL TSEADVRGRT
360 370 380 390 400
GFESADYPQG RWLREAWEVA QSVPTKAVVE AGFKGVEIRE ELTRRRIAAV
410
ASWKEQRCPK PE
Length:412
Mass (Da):46,582
Last modified:June 16, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EB6375406811EAF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU895421 Genomic DNA Translation: ACI77982.1
EU895422 Genomic DNA Translation: ACI77983.1
EU895424 Genomic DNA Translation: ACI77985.1
CP015020 Genomic DNA Translation: AMW42856.1
CP017669 Genomic DNA Translation: APA40557.1
BIAN01000085 Genomic DNA Translation: GCH48299.1
RLEX01000008 Genomic DNA Translation: MDQ89066.1
RLEV01000004 Genomic DNA Translation: MDS17233.1
RLJY01000009 Genomic DNA Translation: MDW74126.1
RMHX01000003 Genomic DNA Translation: MEV95167.1
RMNN01000010 Genomic DNA Translation: MFC81752.1
RMOH01000004 Genomic DNA Translation: MFD98408.1
RNHG01000003 Genomic DNA Translation: MFY58149.1
RNHF01000007 Genomic DNA Translation: MFZ53479.1
RNJD01000004 Genomic DNA Translation: MGB96511.1
RTBW01000018 Genomic DNA Translation: MJD40069.1
RTDX01000003 Genomic DNA Translation: MJF34846.1
RTHS01000008 Genomic DNA Translation: MJK80882.1
RTMR01000009 Genomic DNA Translation: MJR33733.1
RTVT01000017 Genomic DNA Translation: MKB18972.1
RUOF01000002 Genomic DNA Translation: MKX24598.1
RVQE01000003 Genomic DNA Translation: MME82373.1
RVVI01000018 Genomic DNA Translation: MML49724.1
RVZZ01000003 Genomic DNA Translation: MMR44333.1
RWFH01000009 Genomic DNA Translation: MMW37782.1
MTFS01000006 Genomic DNA Translation: OOC82912.1
MRVX01000011 Genomic DNA Translation: PAU17720.1
PGUD01000305 Genomic DNA Translation: PJG30902.1
CP028607 Genomic DNA Translation: QCL46458.1
PDAQ01000004 Genomic DNA Translation: RFQ88394.1
UGCM01000003 Genomic DNA Translation: STI63365.1
QAFU01000010 Genomic DNA Translation: TGF12889.1
QAEX01000011 Genomic DNA Translation: TGG25519.1
QSMR02000002 Genomic DNA Translation: TKT35625.1

NCBI Reference Sequences

More...
RefSeqi
WP_000708496.1, NZ_VODI01000123.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMW42856; AMW42856; ARC77_11720
OEG68525; OEG68525; A7H95_02125

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.7073.peg.458

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU895421 Genomic DNA Translation: ACI77982.1
EU895422 Genomic DNA Translation: ACI77983.1
EU895424 Genomic DNA Translation: ACI77985.1
CP015020 Genomic DNA Translation: AMW42856.1
CP017669 Genomic DNA Translation: APA40557.1
BIAN01000085 Genomic DNA Translation: GCH48299.1
RLEX01000008 Genomic DNA Translation: MDQ89066.1
RLEV01000004 Genomic DNA Translation: MDS17233.1
RLJY01000009 Genomic DNA Translation: MDW74126.1
RMHX01000003 Genomic DNA Translation: MEV95167.1
RMNN01000010 Genomic DNA Translation: MFC81752.1
RMOH01000004 Genomic DNA Translation: MFD98408.1
RNHG01000003 Genomic DNA Translation: MFY58149.1
RNHF01000007 Genomic DNA Translation: MFZ53479.1
RNJD01000004 Genomic DNA Translation: MGB96511.1
RTBW01000018 Genomic DNA Translation: MJD40069.1
RTDX01000003 Genomic DNA Translation: MJF34846.1
RTHS01000008 Genomic DNA Translation: MJK80882.1
RTMR01000009 Genomic DNA Translation: MJR33733.1
RTVT01000017 Genomic DNA Translation: MKB18972.1
RUOF01000002 Genomic DNA Translation: MKX24598.1
RVQE01000003 Genomic DNA Translation: MME82373.1
RVVI01000018 Genomic DNA Translation: MML49724.1
RVZZ01000003 Genomic DNA Translation: MMR44333.1
RWFH01000009 Genomic DNA Translation: MMW37782.1
MTFS01000006 Genomic DNA Translation: OOC82912.1
MRVX01000011 Genomic DNA Translation: PAU17720.1
PGUD01000305 Genomic DNA Translation: PJG30902.1
CP028607 Genomic DNA Translation: QCL46458.1
PDAQ01000004 Genomic DNA Translation: RFQ88394.1
UGCM01000003 Genomic DNA Translation: STI63365.1
QAFU01000010 Genomic DNA Translation: TGF12889.1
QAEX01000011 Genomic DNA Translation: TGG25519.1
QSMR02000002 Genomic DNA Translation: TKT35625.1
RefSeqiWP_000708496.1, NZ_VODI01000123.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMW42856; AMW42856; ARC77_11720
OEG68525; OEG68525; A7H95_02125
PATRICifig|562.7073.peg.458

Phylogenomic databases

eggNOGiENOG4105D4J Bacteria
COG0617 LUCA

Enzyme and pathway databases

BioCyciGCF_001865295:AU473_RS06415-MONOMER

Family and domain databases

CDDicd00077 HDc, 1 hit
cd05398 NT_ClassII-CCAase, 1 hit
HAMAPiMF_01261 CCA_bact_type1, 1 hit
MF_01262 CCA_bact_type2, 1 hit
InterProiView protein in InterPro
IPR012006 CCA_bact
IPR003607 HD/PDEase_dom
IPR006674 HD_domain
IPR002646 PolA_pol_head_dom
IPR032828 PolyA_RNA-bd
PfamiView protein in Pfam
PF01966 HD, 1 hit
PF01743 PolyA_pol, 1 hit
PF12627 PolyA_pol_RNAbd, 1 hit
PIRSFiPIRSF000813 CCA_bact, 1 hit
PROSITEiView protein in PROSITE
PS51831 HD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3SU43_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3SU43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 13, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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