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Protein

Aspartate--ammonia ligase

Gene

asnA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.UniRule annotationSAAS annotation

Pathwayi: L-asparagine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Aspartate--ammonia ligase (WR15_16735), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (A8G17_27630), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA)
This subpathway is part of the pathway L-asparagine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route), the pathway L-asparagine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Asparagine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00134; UER00194

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--ammonia ligaseUniRule annotationSAAS annotation (EC:6.3.1.1UniRule annotationSAAS annotation)
Alternative name(s):
Asparagine synthetase AUniRule annotation
Gene namesi
Name:asnAUniRule annotationImported
ORF Names:A8G17_13235Imported, AL530_002165Imported, AML35_23895Imported, APU18_07725Imported, ARC77_15660Imported, AU473_02200Imported, B7C53_19530Imported, BHF46_03190Imported, BK248_08205Imported, BK334_16030Imported, BK400_00950Imported, BTQ04_25530Imported, BWP17_24885Imported, BXT93_11540Imported, BZL69_24230Imported, C6976_21645Imported, C7B06_18085Imported, C7B07_18585Imported, C7U73_20120Imported, CA268_02905Imported, CR539_00405Imported, CRT55_29330Imported, CSB64_04680Imported, CT143_13735Imported, CVH05_22780Imported, ECONIH1_22050Imported, ECs4686Imported, ERS085366_03542Imported, ERS085383_02621Imported, ERS085386_04250Imported, ERS085404_04413Imported, MS6198_43120Imported, YDC107_2441Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000184168 Componenti: Unassembled WGS sequence
  • UP000231208 Componenti: Unassembled WGS sequence
  • UP000231393 Componenti: Unassembled WGS sequence
  • UP000030317 Componenti: Chromosome
  • UP000238802 Componenti: Chromosome
  • UP000053450 Componenti: Unassembled WGS sequence
  • UP000197917 Componenti: Unassembled WGS sequence
  • UP000234543 Componenti: Chromosome
  • UP000177471 Componenti: Chromosome
  • UP000184459 Componenti: Unassembled WGS sequence
  • UP000094504 Componenti: Chromosome
  • UP000184336 Componenti: Unassembled WGS sequence
  • UP000043139 Componenti: Unassembled WGS sequence
  • UP000222984 Componenti: Unassembled WGS sequence
  • UP000053643 Componenti: Unassembled WGS sequence
  • UP000076106 Componenti: Unassembled WGS sequence
  • UP000196865 Componenti: Unassembled WGS sequence
  • UP000042887 Componenti: Unassembled WGS sequence
  • UP000195177 Componenti: Unassembled WGS sequence
  • UP000235136 Componenti: Chromosome
  • UP000076266 Componenti: Chromosome
  • UP000240660 Componenti: Unassembled WGS sequence
  • UP000044658 Componenti: Unassembled WGS sequence
  • UP000218692 Componenti: Unassembled WGS sequence
  • UP000188967 Componenti: Unassembled WGS sequence
  • UP000241957 Componenti: Unassembled WGS sequence
  • UP000240829 Componenti: Unassembled WGS sequence
  • UP000188999 Componenti: Unassembled WGS sequence
  • UP000239287 Componenti: Unassembled WGS sequence
  • UP000194331 Componenti: Chromosome
  • UP000095493 Componenti: Unassembled WGS sequence
  • UP000045242 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 327AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST315

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CU9 Bacteria
COG2502 LUCA

Family and domain databases

CDDicd00645 AsnA, 1 hit
HAMAPiMF_00555 AsnA, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004618 AsnA
PANTHERiPTHR30073 PTHR30073, 1 hit
PfamiView protein in Pfam
PF03590 AsnA, 1 hit
PIRSFiPIRSF001555 Asp_ammon_ligase, 1 hit
TIGRFAMsiTIGR00669 asnA, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

C3SL47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTAYIAKQR QISFVKSHFS RQLEERLGLI EVQAPILSRV GDGTQDNLSG
60 70 80 90 100
CEKAVQVKVK ALPDAQFEVV HSLAKWKRQT LGQHDFSAGE GLYTHMKALR
110 120 130 140 150
PDEDRLSPLH SVYVDQWDWE RVMGDGERQF STLKSTVEAI WAGIKATEAA
160 170 180 190 200
VSEEFGLAPF LPDQIHFVHS QELLSRYPDL DAKGRERAIA KDLGAVFLVG
210 220 230 240 250
IGGKLSDGHR HDVRAPDYDD WSTPSELGHA GLNGDILVWN PVLEDAFELS
260 270 280 290 300
SMGIRVDADT LKHQLALTGD EDRLQLEWHQ ALLRGEMPQT IGGGIGQSRL
310 320 330
TMLLLQLPHI GQVQCGVWPA AVRESVPSLL
Length:330
Mass (Da):36,650
Last modified:June 16, 2009 - v1
Checksum:i6E8D3A2ACE523FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU892625 Genomic DNA Translation: ACI75191.1
EU892626 Genomic DNA Translation: ACI75192.1
EU892627 Genomic DNA Translation: ACI75193.1
EU892628 Genomic DNA Translation: ACI75194.1
EU892629 Genomic DNA Translation: ACI75195.1
CP009859 Genomic DNA Translation: AIX65741.1
CP015020 Genomic DNA Translation: AMW43586.1
CP015834 Genomic DNA Translation: AOM72280.1
CP017669 Genomic DNA Translation: APA39770.1
CP021202 Genomic DNA Translation: ARR58474.1
CP024147 Genomic DNA Translation: AUJ94055.1
CP024056 Genomic DNA Translation: AUL87607.1
CP025707 Genomic DNA Translation: AUO34632.1
CYAV01000047 Genomic DNA Translation: CTT44247.1
CYBJ01000012 Genomic DNA Translation: CTT82645.1
CYBM01000030 Genomic DNA Translation: CTU12341.1
CYCH01000043 Genomic DNA Translation: CTV85985.1
LNIP01000006 Genomic DNA Translation: KSZ22058.1
LOGT01000159 Genomic DNA Translation: KYS88437.1
MIWY01000003 Genomic DNA Translation: OEN37250.1
MOFD01000018 Genomic DNA Translation: OJK75806.1
MOIL01000016 Genomic DNA Translation: OJP12618.1
MOKZ01000002 Genomic DNA Translation: OJS91246.1
MTPS01000172 Genomic DNA Translation: ONG34803.1
MTFS01000062 Genomic DNA Translation: OOC76020.1
MUBQ01000045 Genomic DNA Translation: OUK90482.1
LYAA01001695 Genomic DNA Translation: OWC16561.1
NBSF01000046 Genomic DNA Translation: OWS83964.1
MRVX01000123 Genomic DNA Translation: PAU09529.1
PEDQ01000009 Genomic DNA Translation: PHX02469.1
PENR01000006 Genomic DNA Translation: PIM28487.1
PGUD01000258 Genomic DNA Translation: PJG31388.1
LORS02000001 Genomic DNA Translation: PNP62086.1
PVPD01000068 Genomic DNA Translation: PSG56860.1
PYPR01000059 Genomic DNA Translation: PSY16823.1
PYQW01000014 Genomic DNA Translation: PSY78325.1
PYQV01000013 Genomic DNA Translation: PSZ15378.1
RefSeqiWP_000845107.1, NZ_PYQW01000014.1

Genome annotation databases

EnsemblBacteriaiAIX65741; AIX65741; ECONIH1_22050
AMW43586; AMW43586; ARC77_15660
AOM72280; AOM72280; MS6198_43120
CTT44247; CTT44247; ERS085366_03542
CTT82645; CTT82645; ERS085383_02621
CTU12341; CTU12341; ERS085386_04250
CTV85985; CTV85985; ERS085404_04413
KHI30630; KHI30630; PU33_15550
KLX90929; KLX90929; SK83_01221
KME62104; KME62104; SM09_04731
KSZ22058; KSZ22058; APU18_07725
KUU44873; KUU44873; AWF22_04030
KXG96933; KXG96933; HMPREF3041_01749
KYS88437; KYS88437; AML35_23895
OAF41633; OAF41633; AXK33_12910
OAO72389; OAO72389; OK10_18810
ODH22669; ODH22669; A6804_13065
OEG66311; OEG66311; A7H95_13105
OEN37250; OEN37250; BHF46_03190
PATRICifig|562.10852.peg.1728

Similar proteinsi

Entry informationi

Entry nameiC3SL47_ECOLX
AccessioniPrimary (citable) accession number: C3SL47
Secondary accession number(s): A0A0J3V972
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 18, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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