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Entry version 46 (26 Feb 2020)
Sequence version 1 (16 Jun 2009)
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Protein
Submitted name:

VirB6

Gene

virB6-5

Organism
Rickettsia africae (strain ESF-5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
RAFR347255:G1GVG-228-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
VirB6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:virB6-5Imported
Ordered Locus Names:RAF_ORF0135Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRickettsia africae (strain ESF-5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri347255 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002305 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei287 – 308HelicalSequence analysisAdd BLAST22
Transmembranei320 – 339HelicalSequence analysisAdd BLAST20
Transmembranei392 – 413HelicalSequence analysisAdd BLAST22
Transmembranei420 – 444HelicalSequence analysisAdd BLAST25
Transmembranei456 – 477HelicalSequence analysisAdd BLAST22
Transmembranei596 – 613HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500293056623 – 1153Sequence analysisAdd BLAST1131

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1028 – 1048Sequence analysisAdd BLAST21
Coiled coili1098 – 1125Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_275941_0_0_5

KEGG Orthology (KO)

More...
KOi
K03201

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECIDERY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007688 Conjugal_tfr_TrbL/VirB6

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04610 TrbL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C3PME6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKNIFITLL ISLLLLSGCT GDTCIDPDDF GFIKFNVSAR YDPEEITSRQ
60 70 80 90 100
EGNQVAPWRD SAYKVNGYPL TIMVRPWSYI LGDKNTSGQL SAWCPWYGQK
110 120 130 140 150
NNTTTLAAFC VKLQPCTFWD NTRLDMCTPN PANQNDAMIS NAPCIMTNGV
160 170 180 190 200
GLYFLIAAKN TDPNISPDSQ SKPQGITQHL GEELTSGYEF YSTSSTGQFL
210 220 230 240 250
EAGGINYQYK GEDKSKYAQS PLYFKIIDKF YNDNSGQYRL VIKSGVTDTR
260 270 280 290 300
PDPLQFLTDL IKGVLFGKDG IIKKTYQQII DTSGYRMSVS AILTLYIMFT
310 320 330 340 350
GFSFLIGNIN LTHVELIVRI LKVSIVSILL STDKAWTFFH DYLFVFFIDG
360 370 380 390 400
VQQILQIINE ASATGPGSQS LLGLLISPQT LSKLFSLLFV DWLGFIYIIL
410 420 430 440 450
YLIALYFIFF LIFKATIIYL TALITIGMII IMGPIFICFM LFNITRSLFE
460 470 480 490 500
NWLRQLISYA LQPIILFTGI AFISMIIRTE IYSTLGFAVC KHDFPNLGPI
510 520 530 540 550
NEIFGSFLED IDPSLGHSIF YWWFPVPMKG GINNFHKANI LVPKDHIIVD
560 570 580 590 600
DSCKNDPDKC KHCAAYECID ERYIELPFLD LVKDAKRISN FINGKFVQLD
610 620 630 640 650
GILLIFVSIY LLSKFNDTAM STAQFIAGTS GNLTEIQKVN QQSYESAAQQ
660 670 680 690 700
MNRPLNYVAK TVSAPVTSRV SAGKEQVRMF FAEKFENMMM GRLEKQALGS
710 720 730 740 750
SANKTVQNEV KRKYGIDSKD VKMNAITDYE NGIAGLLKNL PKGNELKAKE
760 770 780 790 800
LSQMKFTQLR DKIAANKYGV KDYTALSKEQ KAELDKSLKD ANLRELASDA
810 820 830 840 850
NFTRDYQDAY KNAHQEMSGR GVGLFGKNIG VLRSWQEIKH RVDTKRKLKE
860 870 880 890 900
EQRVGIGEKI YAGYTGIKRG ALTAIVGKDL RDAYEGNLTS AEWHDFEYND
910 920 930 940 950
PRLRTYSEKL KDDEKAREHE ELQMHINKEA LAAQADILSP EYLARLEKAG
960 970 980 990 1000
RHSDVEYYQE LAQRKLIHEV HGRLFEEGEP VMMGDRFMCE KATDSQMRDM
1010 1020 1030 1040 1050
IDNAHRKYAE FIDGDRYIRR QEHYDIMHEK AQENLEQTYK ELKDHFKRDD
1060 1070 1080 1090 1100
IKIEEMPALI AQKVKDTAEG AEIDQKITEE LNNFNADVKN YEYSTEVLNK
1110 1120 1130 1140 1150
IEDRKQAITD EVNAQIDKIN KYRENAKMQT YVKPIVNEGR KLRKLEDHLR

NMK
Length:1,153
Mass (Da):131,679
Last modified:June 16, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5E12F70DDF9A28E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001612 Genomic DNA Translation: ACP53106.1

NCBI Reference Sequences

More...
RefSeqi
WP_012719392.1, NC_012633.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACP53106; ACP53106; RAF_ORF0135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
raf:RAF_ORF0135

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA Translation: ACP53106.1
RefSeqiWP_012719392.1, NC_012633.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiACP53106; ACP53106; RAF_ORF0135
KEGGiraf:RAF_ORF0135

Phylogenomic databases

HOGENOMiCLU_275941_0_0_5
KOiK03201
OMAiECIDERY

Enzyme and pathway databases

BioCyciRAFR347255:G1GVG-228-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR007688 Conjugal_tfr_TrbL/VirB6
PfamiView protein in Pfam
PF04610 TrbL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC3PME6_RICAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C3PME6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 26, 2020
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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