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Protein

Glycerol-1-phosphate dehydrogenase [NAD(P)+]

Gene

egsA

Organism
Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.UniRule annotation

Catalytic activityi

sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Binding sitei128NADUniRule annotation1
Metal bindingi171Zinc; catalyticUniRule annotation1
Binding sitei171SubstrateUniRule annotation1
Metal bindingi251Zinc; catalyticUniRule annotation1
Binding sitei255SubstrateUniRule annotation1
Metal bindingi267Zinc; catalyticUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 101NADUniRule annotation5
Nucleotide bindingi119 – 122NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMetal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-1-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.261UniRule annotation)
Short name:
G1P dehydrogenaseUniRule annotation
Short name:
G1PDHUniRule annotation
Alternative name(s):
Enantiomeric glycerophosphate synthaseUniRule annotation
sn-glycerol-1-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:egsAUniRule annotation
Ordered Locus Names:YG5714_1376
OrganismiSulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)
Taxonomic identifieri439386 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000002308 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002064811 – 351Glycerol-1-phosphate dehydrogenase [NAD(P)+]Add BLAST351

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3NEA4
SMRiC3NEA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycerol-1-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228570
KOiK00096
OMAiWYEASVS
OrthoDBiPOG093Z05WV

Family and domain databases

CDDicd08173 Gro1PDH, 1 hit
HAMAPiMF_00497_A G1P_dehydrogenase_A, 1 hit
InterProiView protein in InterPro
IPR023002 G1P_dehydrogenase_arc
IPR032837 G1PDH
IPR016205 Glycerol_DH
PANTHERiPTHR43616 PTHR43616, 1 hit
PfamiView protein in Pfam
PF13685 Fe-ADH_2, 1 hit
PIRSFiPIRSF000112 Glycerol_dehydrogenase, 1 hit

Sequencei

Sequence statusi: Complete.

C3NEA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVKEHVISL PRRVFVGHDI IYDISIYFSQ LGITSPFLIV TGTKYTKKIA
60 70 80 90 100
DRVIENLPKN AKYEVIEIDT ATLDDVYKVE EVVKKVNPNI LLGIGGGKVI
110 120 130 140 150
DVTKYAAFRN NLEFVSIPTS PSHDGITSPF ASIKGLQKPV SVKAKEPLAI
160 170 180 190 200
IADIEILSLS PRRLINAGIG DTIGKIIAVR DWRLAAKLRG EYYGDYTASL
210 220 230 240 250
ALMSAKHAFQ CTKIINKDIK YGVRMLIEAL ISSGVAMGMA GSTRPASGSE
260 270 280 290 300
HLFAHAVELL HPEGVLHGEL VGLGTIIMAY LHGINWKIIR DRLKKIGFPV
310 320 330 340 350
KAKDLGLSDE EVIKALTIAH TIRPERYTIL GDRGLTWSSA EKIARVTKII

D
Length:351
Mass (Da):38,576
Last modified:June 16, 2009 - v1
Checksum:i5E5B69EC9D759FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001403 Genomic DNA Translation: ACP45643.1
RefSeqiWP_012716165.1, NC_012622.1

Genome annotation databases

EnsemblBacteriaiACP45643; ACP45643; YG5714_1376
GeneIDi8761409
KEGGisiy:YG5714_1376

Similar proteinsi

Entry informationi

Entry nameiG1PDH_SULIY
AccessioniPrimary (citable) accession number: C3NEA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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