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Protein

Argininosuccinate synthase

Gene

argG

Organism
Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99CitrullineUniRule annotation1
Binding sitei129ATP; via amide nitrogenUniRule annotation1
Binding sitei131AspartateUniRule annotation1
Binding sitei135AspartateUniRule annotation1
Binding sitei135CitrullineUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei139CitrullineUniRule annotation1
Binding sitei186CitrullineUniRule annotation1
Binding sitei195CitrullineUniRule annotation1
Binding sitei268CitrullineUniRule annotation1
Binding sitei280CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:LS215_1604Imported
OrganismiSulfolobus islandicus (strain L.S.2.15 / Lassen #1)Imported
Taxonomic identifieri429572 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001747 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3MQE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230093
KOiK01940
OMAiPAREWGM
OrthoDBiPOG093Z02NI

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

C3MQE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISIVFKLLL YPFCEMKIVL AYSGGLDTTV SIRWLKETFK AEVITVTVDV
60 70 80 90 100
GQKDDFKKIE ERAYIAGASK HYTIDAIKEF ANNYISYAIK LNGLYEGVYP
110 120 130 140 150
LSTALARPLI AEKVVEVAKK EKADAVAHGS TSKGNDQVRF DLTVKALYPD
160 170 180 190 200
VKIIAPARIW SMTREDEIKY AKEKGIPIKV ESSKYSIDEN LWGRSIEGDI
210 220 230 240 250
ISDPSVEVTE DAFEWTKQIA NNKEIISIEF SNGVPTAVDG EQMELHKLIG
260 270 280 290 300
LLNLKFGNHG FGRVEHIENR VVGFKSREVY EVPAALGLIY SHIDLEKTIY
310 320 330 340 350
TPTELRFKKY VDQLWSDLVY QGLWFEPLRE TLHKIADEMN KWIAGEVRVE
360 370 380 390 400
VNNGSFRILG RKSDYSPYSE KLASYNKGWY PSDEMARGFI EIWGMHSLIA

RRVRGL
Length:406
Mass (Da):46,227
Last modified:June 16, 2009 - v1
Checksum:iF1868C10CC2AE2D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA Translation: ACP35609.1
RefSeqiWP_012713786.1, NC_012589.1

Genome annotation databases

EnsemblBacteriaiACP35609; ACP35609; LS215_1604
GeneIDi8761532
KEGGisis:LS215_1604

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001399 Genomic DNA Translation: ACP35609.1
RefSeqiWP_012713786.1, NC_012589.1

3D structure databases

ProteinModelPortaliC3MQE6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP35609; ACP35609; LS215_1604
GeneIDi8761532
KEGGisis:LS215_1604

Phylogenomic databases

HOGENOMiHOG000230093
KOiK01940
OMAiPAREWGM
OrthoDBiPOG093Z02NI

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC3MQE6_SULIL
AccessioniPrimary (citable) accession number: C3MQE6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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