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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:BAMEG_0599
OrganismiBacillus anthracis (strain CDC 684 / NRRL 3495)
Taxonomic identifieri568206 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001648421 – 180Bifunctional protein PyrRAdd BLAST180

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3L735
SMRiC3L735
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 113PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

C3L735-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEKAVVLDD QMIRRALTRI SHEIVERNKG VDNCVLVGIK TRGIFIAQRL
60 70 80 90 100
AERIGQIEGK EMEVGELDIT LYRDDLTLQS KNKEPLVKGS DIPVDITKKK
110 120 130 140 150
VILVDDVLYT GRTVRAAMDA LMDLGRPSQI QLAVLVDRGH RELPIRADYV
160 170 180
GKNIPTSSEE RIEVDLQETD QQDRVSIYDK
Length:180
Mass (Da):20,409
Last modified:June 16, 2009 - v1
Checksum:i3254DE877B7E2510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA Translation: ACP13988.1
RefSeqiWP_001156491.1, NC_012581.1

Genome annotation databases

EnsemblBacteriaiACP13988; ACP13988; BAMEG_0599
GeneIDi31628657
KEGGibah:BAMEG_0599

Similar proteinsi

Entry informationi

Entry nameiPYRR_BACAC
AccessioniPrimary (citable) accession number: C3L735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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