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Protein

60 kDa chaperonin

Gene

groL

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:CLJ_B3579
OrganismiClostridium botulinum (strain 657 / Type Ba4)
Taxonomic identifieri515621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002121921 – 54160 kDa chaperoninAdd BLAST541

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3KUC8
SMRiC3KUC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

C3KUC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSLLFGEQ ARRSMEAGVD KLADTVRVTL GPKGRNVVLD KKFGSPLITN
60 70 80 90 100
DGVTIAREIE LEDPYENMGA QLVKEVATKT NDVAGDGTTT ATLLAQAIIR
110 120 130 140 150
EGLKNVTAGA NPIQIRTGIR KAVEKAVEEI KVISKPVNGK EDIARVAAIS
160 170 180 190 200
AASEEVGKLI ADAMERVGND GVITVEESKS MGTDLEVVEG MQFDRGYVSA
210 220 230 240 250
YMVTDTEKME AVLDDVYILI TDKKISNIQE ILPILEQIVQ QGKKLLIISE
260 270 280 290 300
DIEGEALSTL VLNKLRGTFT CVGVKAPGFG DRRKEMLQDI AILTGGEVIS
310 320 330 340 350
EELGRDLKDV TIDMLGTADS VKVTKENTTI VNGKGDKVAI KERVSQIRVQ
360 370 380 390 400
IEDTTSEFDK EKLQERLAKL AGGVAVIRVG AATETELKEE KLRIEDALAA
410 420 430 440 450
TKAAVEEGIV PGGGTAYIDI IPKIADLTSD IIDVKLGIDI IRKALEEPVR
460 470 480 490 500
QIANNAGVEG SVIIEKVKAS EAGVGYDALN DKYVDMLKTG IVDPTKVTRS
510 520 530 540
ALQNAASIAS TFLTTEAAVA DIPEKENTPP MAPGMGMDGM Y
Length:541
Mass (Da):57,936
Last modified:June 16, 2009 - v1
Checksum:i5A130C3A7664E20F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001083 Genomic DNA Translation: ACQ52812.1
RefSeqiWP_003360385.1, NC_012658.1

Genome annotation databases

EnsemblBacteriaiACQ52812; ACQ52812; CLJ_B3579
KEGGicbi:CLJ_B3579

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001083 Genomic DNA Translation: ACQ52812.1
RefSeqiWP_003360385.1, NC_012658.1

3D structure databases

ProteinModelPortaliC3KUC8
SMRiC3KUC8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ52812; ACQ52812; CLJ_B3579
KEGGicbi:CLJ_B3579

Phylogenomic databases

HOGENOMiHOG000076290
KOiK04077
OMAiTDTDKME
OrthoDBiPOG091H00E7

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_CLOB6
AccessioniPrimary (citable) accession number: C3KUC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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