UniProtKB - C1P615 (IBSC_ECOLI)
Protein
Small toxic protein IbsC
Gene
ibsC
Organism
Escherichia coli (strain K12)
Status
Functioni
Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response, the psp phage shock and a number of membrane protein genes.1 Publication
Miscellaneous
Part of the SIBc repeat region (formerly known as QUAD1c), encoded on the opposite strand from the sibC (formerly known as rygC) RNA.
GO - Biological processi
- programmed cell death Source: EcoCyc
Keywordsi
Biological process | Toxin-antitoxin system |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2857 |
Names & Taxonomyi
Protein namesi | Recommended name: Small toxic protein IbsC |
Gene namesi | Name:ibsC Ordered Locus Names:b4665, JW2879.1 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
None seen. An isbC overproducing strain cannot be made in the absence of the sibC gene.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000386422 | 1 – 19 | Small toxic protein IbsCAdd BLAST | 19 |
Proteomic databases
PRIDEi | C1P615 |
Expressioni
Inductioni
The sibC sRNA prevents the toxic effects of IbsC overproduction, either by destabilizing the transcript and/or preventing its translation. Expression of the proteinaceous toxin is controlled by antisense sRNA SibC.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the Ibs toxic protein family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR025881, Toxin_Ibs |
Pfami | View protein in Pfam PF13956, Ibs_toxin, 1 hit |
i Sequence
Sequence statusi: Complete.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO60007.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_010723220.1, NZ_SSUV01000019.1 YP_002791255.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | ACO60007; ACO60007; b4665 |
GeneIDi | 58460575 7751627 |
KEGGi | eco:b4665 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO60007.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_010723220.1, NZ_SSUV01000019.1 YP_002791255.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | C1P615 |
Genome annotation databases
EnsemblBacteriai | ACO60007; ACO60007; b4665 |
GeneIDi | 58460575 7751627 |
KEGGi | eco:b4665 |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2857 |
Miscellaneous databases
PROi | PR:C1P615 |
Family and domain databases
InterProi | View protein in InterPro IPR025881, Toxin_Ibs |
Pfami | View protein in Pfam PF13956, Ibs_toxin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBSC_ECOLI | |
Accessioni | C1P615Primary (citable) accession number: C1P615 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 13, 2009 |
Last sequence update: | May 26, 2009 | |
Last modified: | February 10, 2021 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families