UniProtKB - C1P611 (SHOB_ECOLI)
Protein
Small toxic protein ShoB
Gene
shoB
Organism
Escherichia coli (strain K12)
Status
Functioni
Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes.1 Publication
Miscellaneous
Entirely encoded within a small RNA previously known as ryfB.Curated
GO - Biological processi
- programmed cell death Source: EcoCyc
Keywordsi
Biological process | Toxin-antitoxin system |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2860 |
Names & Taxonomyi
Protein namesi | Recommended name: Small toxic protein ShoB |
Gene namesi | Name:shoB Synonyms:ryfB, yphI Ordered Locus Names:b4687, JW2546.1 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Membrane Curated; Single-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 24 | HelicalSequence analysisAdd BLAST | 18 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000386426 | 1 – 26 | Small toxic protein ShoBAdd BLAST | 26 |
Proteomic databases
PaxDbi | C1P611 |
PRIDEi | C1P611 |
Expressioni
Inductioni
In exponential phase. The ohsC RNA (previously known as ryfC) prevents the toxic effects of shoB overproduction, probably by repressing its translation. Expression of the proteinaceous toxin is controlled by antisense sRNA OhsC.1 Publication
i Sequence
Sequence statusi: Complete.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO60003.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_000128776.1, NZ_STEB01000011.1 YP_002791251.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | ACO60003; ACO60003; b4687 |
GeneIDi | 58460978 7751620 |
KEGGi | eco:b4687 |
PATRICi | fig|83333.103.peg.3447 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO60003.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_000128776.1, NZ_STEB01000011.1 YP_002791251.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 511145.b4687 |
Proteomic databases
PaxDbi | C1P611 |
PRIDEi | C1P611 |
Genome annotation databases
EnsemblBacteriai | ACO60003; ACO60003; b4687 |
GeneIDi | 58460978 7751620 |
KEGGi | eco:b4687 |
PATRICi | fig|83333.103.peg.3447 |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2860 |
Miscellaneous databases
PROi | PR:C1P611 |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHOB_ECOLI | |
Accessioni | C1P611Primary (citable) accession number: C1P611 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 13, 2009 |
Last sequence update: | May 26, 2009 | |
Last modified: | February 10, 2021 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |