UniProtKB - C1P5Z7 (SGRT_ECOLI)
Protein
Putative inhibitor of glucose uptake transporter SgrT
Gene
sgrT
Organism
Escherichia coli (strain K12)
Status
Functioni
Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild-type levels of PtsG.1 Publication
Miscellaneous
Entirely encoded within the transcript for the small RNA sgrS.
GO - Molecular functioni
- enzyme inhibitor activity Source: EcoCyc
GO - Biological processi
- negative regulation of glucose import Source: EcoCyc
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2842 |
Protein family/group databases
TCDBi | 4.A.1.1.1, the pts glucose-glucoside (glc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Putative inhibitor of glucose uptake transporter SgrT |
Gene namesi | Name:sgrT Ordered Locus Names:b4662, JW0068.1 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
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PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000381978 | 1 – 43 | Putative inhibitor of glucose uptake transporter SgrTAdd BLAST | 43 |
Proteomic databases
PaxDbi | C1P5Z7 |
PRIDEi | C1P5Z7 |
Expressioni
Inductioni
By (toxic) non-metabolizable glucose phosphate analogs under the control of SgrR (at protein level).2 Publications
i Sequence
Sequence statusi: Complete.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO59989.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_001248770.1, NZ_STEB01000010.1 YP_002791237.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | ACO59989; ACO59989; b4662 |
GeneIDi | 48132657 7751624 |
KEGGi | eco:b4662 |
PATRICi | fig|1411691.4.peg.2212 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: ACO59989.1 AP009048 Genomic DNA No translation available. |
RefSeqi | WP_001248770.1, NZ_STEB01000010.1 YP_002791237.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 511145.b4662 |
Protein family/group databases
TCDBi | 4.A.1.1.1, the pts glucose-glucoside (glc) family |
Proteomic databases
PaxDbi | C1P5Z7 |
PRIDEi | C1P5Z7 |
Genome annotation databases
EnsemblBacteriai | ACO59989; ACO59989; b4662 |
GeneIDi | 48132657 7751624 |
KEGGi | eco:b4662 |
PATRICi | fig|1411691.4.peg.2212 |
Phylogenomic databases
eggNOGi | ENOG5031KWV, Bacteria |
Enzyme and pathway databases
BioCyci | EcoCyc:MONOMER0-2842 |
Miscellaneous databases
PROi | PR:C1P5Z7 |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SGRT_ECOLI | |
Accessioni | C1P5Z7Primary (citable) accession number: C1P5Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | May 26, 2009 | |
Last modified: | October 7, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |