UniProtKB - C1K304 (C1K304_ORYLA)
Protein
Submitted name:
Forkhead box O5
Gene
foxo3
Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 135 – 229 | Fork-headPROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- chordate embryonic development Source: Ensembl
- glucose homeostasis Source: GO_Central
- insulin receptor signaling pathway Source: GO_Central
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of defense response to virus Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- primitive hemopoiesis Source: Ensembl
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Forkhead box O5Imported |
Gene namesi | Name:foxo3Imported |
Organismi | Oryzias latipes (Japanese rice fish) (Japanese killifish)Imported |
Taxonomic identifieri | 8090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Ovalentaria › Atherinomorphae › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationARBA annotation
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationInteractioni
GO - Molecular functioni
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8090.ENSORLP00000016870 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 229 | Fork-headInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 133 | DisorderedSequence analysisAdd BLAST | 133 | |
Regioni | 210 – 334 | DisorderedSequence analysisAdd BLAST | 125 | |
Regioni | 410 – 432 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 74 – 88 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 96 – 133 | PolarSequence analysisAdd BLAST | 38 | |
Compositional biasi | 272 – 309 | PolarSequence analysisAdd BLAST | 38 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000161401 |
HOGENOMi | CLU_023456_1_0_1 |
OMAi | DPVMTFG |
OrthoDBi | 1160384at2759 |
TreeFami | TF315583 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032067, FOXO-TAD IPR032068, FOXO_KIX-bd IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16676, FOXO-TAD, 1 hit PF16675, FOXO_KIX_bdg, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
C1K304-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAPLPDAL PDLDVAIDPD FEPQKRPRSC TWPLPRPDSA AVKPESNDTD
60 70 80 90 100
IIPEEEDDEE DATPTAARVN GSVAAAEDQS SNSPVGDGAL PSPGQESGGS
110 120 130 140 150
PLSSHSPAAT SGALTPSGLA AAQTPRKTSS RRNAWGNLSY ADLITQAIES
160 170 180 190 200
SPEKRLTLSQ IYDWMVRSIP YFKDKGDSNS SAGWKNSIRH NLSLHSRFIR
210 220 230 240 250
VQNEGTGKSS WWMINPEGGK GGKAPRRRAV SMDNSNKYTK SARGRAAKKK
260 270 280 290 300
AALQAAAAAA GEGGGDSPSG LSRWPGSPTS HSTEELDGGW TDFRSRTNSN
310 320 330 340 350
ASTVSGHLSP IMANPELDEV PDDEAPLSPM IYSSPGRALS PGNAISNGKA
360 370 380 390 400
APAELPRLAD LTGTMNLNDG ITDELMDDLL DNIKLVPPSS SQNLQNGSSG
410 420 430 440 450
FTFGSKSNGI SLTSSTSSPS SNSSSNGGSN GYSNSIFGSQ AIGSSLRSSP
460 470 480 490 500
MQTIQENKQT SFSSISMSGF GSQTLQDLLN SGSHNHSDVM MTQSDPLMSQ
510 520 530 540 550
ASSAAVNSQN SRRGLILRND PVMTFGTSGG IQASQRDVLQ TNNQNQSSMR
560 570 580 590 600
SRNGGLNLVN EANTLANAKQ QLLLSPLGGN GSSTMQIDPS IFLNGTVSSS
610 620 630 640 650
GGVSQDRFPT DLDLDIFNGS LECDMDSIIR NDLMDADGLD FNFDSLVNMN
660
GVSNFTSTKQ SSQSWVPG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ792673 mRNA Translation: ACO57477.1 |
RefSeqi | NP_001153937.1, NM_001160465.1 XP_011489777.1, XM_011491475.1 XP_011489778.1, XM_011491476.1 |
Genome annotation databases
Ensembli | ENSORLT00000016871; ENSORLP00000016870; ENSORLG00000013450 ENSORLT00000044385; ENSORLP00000037109; ENSORLG00000013450 |
GeneIDi | 100301621 |
KEGGi | ola:100301621 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ792673 mRNA Translation: ACO57477.1 |
RefSeqi | NP_001153937.1, NM_001160465.1 XP_011489777.1, XM_011491475.1 XP_011489778.1, XM_011491476.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8090.ENSORLP00000016870 |
Genome annotation databases
Ensembli | ENSORLT00000016871; ENSORLP00000016870; ENSORLG00000013450 ENSORLT00000044385; ENSORLP00000037109; ENSORLG00000013450 |
GeneIDi | 100301621 |
KEGGi | ola:100301621 |
Organism-specific databases
CTDi | 2310 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000161401 |
HOGENOMi | CLU_023456_1_0_1 |
OMAi | DPVMTFG |
OrthoDBi | 1160384at2759 |
TreeFami | TF315583 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032067, FOXO-TAD IPR032068, FOXO_KIX-bd IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16676, FOXO-TAD, 1 hit PF16675, FOXO_KIX_bdg, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C1K304_ORYLA | |
Accessioni | C1K304Primary (citable) accession number: C1K304 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 26, 2009 |
Last sequence update: | May 26, 2009 | |
Last modified: | December 2, 2020 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |