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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Avin_36890
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002128161 – 351Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST351

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_36890

Structurei

3D structure databases

ProteinModelPortaliC1DRW0
SMRiC1DRW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

C1DRW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKQPSLSYK DAGVDIDAGE ALVERIKGVA RRTARPEVMG GLGGFGALCE
60 70 80 90 100
IPAGYRQPVL VSGTDGVGTK LRLAMNLGKH DSIGIDLVAM CVNDLVVCGA
110 120 130 140 150
EPLFFLDYYA TGKLNVDVAA RVVAGIGEGC EMAGCALVGG ETAEMPGMYE
160 170 180 190 200
GEDYDLAGFC VGVVEKSEII DGAKVAAGDA LIALPSSGPH SNGYSLIRKI
210 220 230 240 250
LELSGTDVAG ATLDGKPLAD LLMAPTRIYV KPLLKLIRET GAVKAMAHIT
260 270 280 290 300
GGGLTENIPR VLPQGTRAVI DVASWTRPAV FDWLQEKGNV DEREMHRVLN
310 320 330 340 350
CGVGMVVCVA RDKVEQALAV LRAAGEQPWL IGDIAAGDGA ERVQLHNLKA

H
Length:351
Mass (Da):36,801
Last modified:May 26, 2009 - v1
Checksum:i17265F8779D892A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA Translation: ACO79835.1
RefSeqiWP_012702210.1, NC_012560.1

Genome annotation databases

EnsemblBacteriaiACO79835; ACO79835; Avin_36890
KEGGiavn:Avin_36890

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA Translation: ACO79835.1
RefSeqiWP_012702210.1, NC_012560.1

3D structure databases

ProteinModelPortaliC1DRW0
SMRiC1DRW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_36890

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO79835; ACO79835; Avin_36890
KEGGiavn:Avin_36890

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229090
KOiK01933
OMAiNHCVNDI
OrthoDBiPOG091H0128

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00129

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPUR5_AZOVD
AccessioniPrimary (citable) accession number: C1DRW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 10, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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