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Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Manganese 2UniRule annotation1
Metal bindingi271Manganese 1UniRule annotation1
Metal bindingi271Manganese 2UniRule annotation1
Active sitei278UniRule annotation1
Metal bindingi289Manganese 2UniRule annotation1
Metal bindingi348Manganese 1UniRule annotation1
Metal bindingi350Manganese 1UniRule annotation1
Metal bindingi350Manganese 2UniRule annotation1
Active sitei352UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding

Protein family/group databases

MEROPSiM17.003

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
Alternative name(s):
Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
Short name:
LAPUniRule annotation
Leucyl aminopeptidaseUniRule annotation
Gene namesi
Name:pepAUniRule annotation
Ordered Locus Names:Avin_11650
OrganismiAzotobacter vinelandii (strain DJ / ATCC BAA-1303)
Taxonomic identifieri322710 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter
Proteomesi
  • UP000002424 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002038241 – 496Probable cytosol aminopeptidaseAdd BLAST496

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_11650

Structurei

3D structure databases

ProteinModelPortaliC1DPG2
SMRiC1DPG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
HOGENOMiHOG000243132
KOiK01255
OMAiMKNTGPR
OrthoDBiPOG091H01BT

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

Sequencei

Sequence statusi: Complete.

C1DPG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLVVKSTSP QTLKTATLVV AVGEGRKLGA TAKAIDQAAD GALSAALKRG
60 70 80 90 100
DLAGKVGQTL LLHAVPNLKA ERVLLVGAGK EGELSDRQFR KIAAATYGAL
110 120 130 140 150
KGLGGSDAAL TLGELQVKGR DTYGKTRLLA ETLLDATYAF DRFKSEKASA
160 170 180 190 200
PVLKKLVLLC DKAGQAEVER AASHAQAIVD GMALTRDLGN LPPNLCHPTS
210 220 230 240 250
LASEAKALAK TYDTLKVEVL DEKKLKELGM GAFLAVAQGS DQPPRLIVLD
260 270 280 290 300
YQGGKKDEQP FVLVGKGITF DSGGISLKPG SGMDEMKYDM CGAASVLGTF
310 320 330 340 350
RALLELALPI NVVGLLACAE NMPSGGATRP GDIVTSMSGQ TVEILNTDAE
360 370 380 390 400
GRLVLCDALT YAERFKPQAV IDIATLTGAC ITALGTQASG LMGNDDDLIR
410 420 430 440 450
QVLEAGEHAA DRAWQLPLFE EYQEQLDSPF ADMANIGGPK AGTITAACFL
460 470 480 490
SRFAKNYHWA HLDIAGTAWI SGGKEKGATG RPVPLLTQFL LDRSAP
Length:496
Mass (Da):52,115
Last modified:May 26, 2009 - v1
Checksum:i5F715C80C9166AB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA Translation: ACO77394.1
RefSeqiWP_012699815.1, NC_012560.1

Genome annotation databases

EnsemblBacteriaiACO77394; ACO77394; Avin_11650
KEGGiavn:Avin_11650

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001157 Genomic DNA Translation: ACO77394.1
RefSeqiWP_012699815.1, NC_012560.1

3D structure databases

ProteinModelPortaliC1DPG2
SMRiC1DPG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_11650

Protein family/group databases

MEROPSiM17.003

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO77394; ACO77394; Avin_11650
KEGGiavn:Avin_11650

Phylogenomic databases

eggNOGiENOG4105BZ6 Bacteria
COG0260 LUCA
HOGENOMiHOG000243132
KOiK01255
OMAiMKNTGPR
OrthoDBiPOG091H01BT

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
HAMAPiMF_00181 Cytosol_peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR000819 Peptidase_M17_C
IPR023042 Peptidase_M17_leu_NH2_pept
IPR008283 Peptidase_M17_N
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF00883 Peptidase_M17, 1 hit
PF02789 Peptidase_M17_N, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMPA_AZOVD
AccessioniPrimary (citable) accession number: C1DPG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 10, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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