Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:ROP_65550
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987061 – 2402-phospho-L-lactate guanylyltransferaseAdd BLAST240

Proteomic databases

PRIDEiC1B2N5

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_65550

Structurei

3D structure databases

SMRiC1B2N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

C1B2N5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTATRSVAP RAHVLVAVKE LHAAKTRLSG VFDTDDRTGL VLSMLRDTLA
60 70 80 90 100
VVSDVATVVG VTVVTPDPAV ARLARSVGAH VYADPAPVAA GDPADEGGTE
110 120 130 140 150
HGLNAALAAA AEHVRRNESG VDVVALQADL PSLRGGEFGE ALAAARTGGR
160 170 180 190 200
SVVVDHHGTG TAALFSCDPE VPLDPRFGPG SAKRHLESGA RPLDGHWPGL
210 220 230 240
RTDVDTADDL DAAQALGVGP ATRAALDALE HSAPSHCGNE
Length:240
Mass (Da):24,435
Last modified:May 26, 2009 - v1
Checksum:iA8B5EA258CCD04C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA Translation: BAH54802.1
RefSeqiWP_015890248.1, NC_012522.1

Genome annotation databases

EnsemblBacteriaiBAH54802; BAH54802; ROP_65550
KEGGirop:ROP_65550
PATRICifig|632772.20.peg.6841

Similar proteinsi

Entry informationi

Entry nameiCOFC_RHOOB
AccessioniPrimary (citable) accession number: C1B2N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 26, 2009
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again