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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincUniRule annotation1
Metal bindingi93ZincUniRule annotation1
Metal bindingi163ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:JTY_3674
OrganismiMycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Taxonomic identifieri561275 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001249221 – 202GTP cyclohydrolase 1Add BLAST202

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC1AI67
SMRiC1AI67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

C1AI67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLDSRSAS ARIRVFDQQR AEAAVRELLY AIGEDPDRDG LVATPSRVAR
60 70 80 90 100
SYREMFAGLY TDPDSVLNTM FDEDHDELVL VKEIPMYSTC EHHLVAFHGV
110 120 130 140 150
AHVGYIPGDD GRVTGLSKIA RLVDLYAKRP QVQERLTSQI ADALMKKLDP
160 170 180 190 200
RGVIVVIEAE HLCMAMRGVR KPGSVTTTSA VRGLFKTNAA SRAEALDLIL

RK
Length:202
Mass (Da):22,395
Last modified:May 26, 2009 - v1
Checksum:i7ED8293B83CB39DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010918 Genomic DNA Translation: BAH27946.1
RefSeqiWP_003899597.1, NZ_CP014566.1

Genome annotation databases

EnsemblBacteriaiBAH27946; BAH27946; JTY_3674
KEGGimbt:JTY_3674

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010918 Genomic DNA Translation: BAH27946.1
RefSeqiWP_003899597.1, NZ_CP014566.1

3D structure databases

ProteinModelPortaliC1AI67
SMRiC1AI67
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH27946; BAH27946; JTY_3674
KEGGimbt:JTY_3674

Phylogenomic databases

HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00860 GTP_CYCLOHYDROL_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCH1_MYCBT
AccessioniPrimary (citable) accession number: C1AI67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 10, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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