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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:RER_24130
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002204 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987051 – 2252-phospho-L-lactate guanylyltransferaseAdd BLAST225

Interactioni

Protein-protein interaction databases

STRINGi234621.RER_24130

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZXN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHAIVAVKSL RSAKSRLAGE LDADARADLV LAMLHDTLAT VAAVSAIDTV
60 70 80 90 100
TVVTPDPTVA ALAYSVGVTV YADPAPHISL TNGASPRAEE TLNAALSAAA
110 120 130 140 150
ADIRAKRGVV DLVVLQADLP AMQPSELTEA VAAARSGGRS VVVDHHGTGT
160 170 180 190 200
SALFACGESA LDPRFGPESA RGHANSGARP LNGQWPGLRT DVDTHADLDT
210 220
VRALGVGPAT LASLTRLKAT PSNSR
Length:225
Mass (Da):22,905
Last modified:May 26, 2009 - v1
Checksum:i9D9BC81828E2ACE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA Translation: BAH33121.1

Genome annotation databases

EnsemblBacteriaiBAH33121; BAH33121; RER_24130
KEGGirer:RER_24130
PATRICifig|234621.6.peg.2919

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA Translation: BAH33121.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234621.RER_24130

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH33121; BAH33121; RER_24130
KEGGirer:RER_24130
PATRICifig|234621.6.peg.2919

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Enzyme and pathway databases

UniPathwayi
UPA00071

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_RHOE4
AccessioniPrimary (citable) accession number: C0ZXN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 26, 2009
Last modified: October 10, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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