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Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Rhodococcus erythropolis (strain PR4 / NBRC 100887)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

With S4 and S5 plays an important role in translational accuracy.UniRule annotation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12UniRule annotation
Gene namesi
Name:rpsLUniRule annotation
Ordered Locus Names:RER_17610
OrganismiRhodococcus erythropolis (strain PR4 / NBRC 100887)
Taxonomic identifieri234621 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002204 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002059241 – 12430S ribosomal protein S12Add BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei893-methylthioaspartic acidBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.UniRule annotation

Protein-protein interaction databases

STRINGi234621.RER_17610

Structurei

3D structure databases

SMRiC0ZVT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uS12 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UKE Bacteria
COG0048 LUCA
HOGENOMiHOG000040063
KOiK02950
OMAiKRGVCTA
OrthoDBiPOG091H025P

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
HAMAPiMF_00403_B Ribosomal_S12_B, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZVT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTINQLVRK GRRDKTAKVK TAALKGSPQR RGVCTRVYTT TPKKPNSALR
60 70 80 90 100
KVARVRLTTS VEVTAYIPGE GHNLQEHSMV LVRGGRVKDL PGVRYKIIRG
110 120
SLDTQGVKGR KQARSRYGAK KEKS
Length:124
Mass (Da):13,781
Last modified:May 26, 2009 - v1
Checksum:i2C4332A9F65F1488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA Translation: BAH32469.1
RefSeqiWP_003941908.1, NC_012490.1

Genome annotation databases

EnsemblBacteriaiBAH32469; BAH32469; RER_17610
GeneIDi31541531
KEGGirer:RER_17610

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008957 Genomic DNA Translation: BAH32469.1
RefSeqiWP_003941908.1, NC_012490.1

3D structure databases

SMRiC0ZVT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234621.RER_17610

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH32469; BAH32469; RER_17610
GeneIDi31541531
KEGGirer:RER_17610

Phylogenomic databases

eggNOGiENOG4108UKE Bacteria
COG0048 LUCA
HOGENOMiHOG000040063
KOiK02950
OMAiKRGVCTA
OrthoDBiPOG091H025P

Family and domain databases

CDDicd03368 Ribosomal_S12, 1 hit
HAMAPiMF_00403_B Ribosomal_S12_B, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005679 Ribosomal_S12_bac
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
PRINTSiPR01034 RIBOSOMALS12
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00981 rpsL_bact, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRS12_RHOE4
AccessioniPrimary (citable) accession number: C0ZVT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: October 10, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
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Main funding by: National Institutes of Health

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