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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi491MagnesiumUniRule annotation1
Metal bindingi497MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-3511-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BBR47_34250
OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Taxonomic identifieri358681 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
Proteomesi
  • UP000001877 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857241 – 715Polyribonucleotide nucleotidyltransferaseAdd BLAST715

Proteomic databases

PRIDEiC0ZF43

Interactioni

Protein-protein interaction databases

STRINGi358681.BBR47_34250

Structurei

3D structure databases

ProteinModelPortaliC0ZF43
SMRiC0ZF43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini558 – 617KHUniRule annotationAdd BLAST60
Domaini627 – 695S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

C0ZF43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQQYRTYDF ELAGRKLTLE FGKMAKQAHG SVLVRYGDTA ILSAVTVSKE
60 70 80 90 100
PKPLDFFPLT VNYEERLYAV GKIPGGFIKR EGRPSEKAIL ASRLIDRPVR
110 120 130 140 150
PLFAEGFRND VQIVNTVLSV DQDCSPEIAA MIGTSAALCV SEIPFEGPIA
160 170 180 190 200
GVIVGRIDGE FVINPTVAQA EKSDIHLTVA GTHKAINMVE AAANQVPEAI
210 220 230 240 250
MLEAIMAGHD VIKQLVEFQN MIVSEIGKQK MEVILHEVDP EIDQAVRAYA
260 270 280 290 300
EARLKEAVRI EEKQARYDAI DDIKAETKEH FAAKDAEAYP EQEKMISEVL
310 320 330 340 350
GNIVKDEVRR LITDEKVRPD GRALNEIRPL SSETTILSRT HGSAMFTRGQ
360 370 380 390 400
TQALSVCTLG ALGDVQILDG LGLEESKRFM HHYNFPPYSV GEARPLRPPG
410 420 430 440 450
RREIGHGALG ERAIEPIIPS EVEFPYTIRL VSEVIESNGS TSQASICASV
460 470 480 490 500
LALMDAGVPI KAPVAGIAMG LIMSKDEKSF SILTDIQGME DHLGDMDFKV
510 520 530 540 550
AGTEAGVTAI QMDIKISGIN REILELALEQ ARVGRLHILN HMMSTISEPR
560 570 580 590 600
KELSPYAPKI MTMTINPEKI RDVIGPQGRV INKIIEETGV KIDIEQDGRV
610 620 630 640 650
FIASINHEAN LRAKQIIEDL VREVAVGQVY LGTVKRVEKY GAFIELFAGK
660 670 680 690 700
EGLCHISQLA EERVAKTEDV VAVGDKVQVK VTEIDDQGRV NLSRKAVLKE
710
QAAAEQAAET PTKAE
Length:715
Mass (Da):78,518
Last modified:May 26, 2009 - v1
Checksum:iC4205DC2656751F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008955 Genomic DNA Translation: BAH44402.1
RefSeqiWP_015891706.1, NC_012491.1

Genome annotation databases

EnsemblBacteriaiBAH44402; BAH44402; BBR47_34250
GeneIDi29260685
KEGGibbe:BBR47_34250

Similar proteinsi

Entry informationi

Entry nameiPNP_BREBN
AccessioniPrimary (citable) accession number: C0ZF43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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