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UniProtKB - C0SPA7 (YUKB_BACSU)

Entry version 59 (12 Aug 2020)
Sequence version 1 (05 May 2009)
Previous versions | rss
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Protein

ESX secretion system protein YukB

Gene

yukB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for YukE secretion. Probable component or regulator of the ESX/ESAT-6-like secretion system (BsEss).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi682 – 689ATPPROSITE-ProRule annotation8
Nucleotide bindingi1010 – 1017ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		BSUB:BSU31875-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ESX secretion system protein YukBCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yukB
Synonyms:yukA, yukBA
Ordered Locus Names:BSU31875
ORF Names:BSU31880
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking this gene are blocked in YukE secretion (PubMed:23861817, PubMed:24798022). They display an increased bacteriophage SPP1 resistance phenotype (PubMed:15576783).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003836331 – 1495ESX secretion system protein YukBAdd BLAST1495

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		C0SPA7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		224308.BSU31875

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		C0SPA7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini661 – 858FtsK 1PROSITE-ProRule annotationAdd BLAST198
Domaini993 – 1177FtsK 2PROSITE-ProRule annotationAdd BLAST185

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EssC family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0433, Bacteria
COG1674, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		C0SPA7

Identification of Orthologs from Complete Genome Data

More...OMAi		WEWMKWL

Database for complete collections of gene phylogenies

More...PhylomeDBi		C0SPA7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023839, Firmicutes_EssC_C
IPR022206, Firmicutes_EssC_N
IPR002543, FtsK_dom
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01580, FtsK_SpoIIIE, 3 hits
PF12538, FtsK_SpoIIIE_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 3 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03928, T7_EssCb_Firm, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50901, FTSK, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C0SPA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLWVFYQN NVQKLNLSNL PSSHPVTIGP DVKDSVTIST IPFNSGVISL 
        60         70         80         90        100
KRKESGGQYE VFLGNDCLGT IETDISFTLQ TDQQDIRLIL TGSEPEKSVY 
       110        120        130        140        150
FTGNRDEIVC SSEKTNADIY LNPQDFAFAE QSTFSLLRAG GSWSVRPESG 
       160        170        180        190        200
TIFLNGEKIN ANTPLKPGDE IFWNFTQMRV TEQDLLEIVH YAQFETALTE 
       210        220        230        240        250
TVKPSTEMQK KYPQYRRTPR MVYDLPDDRV SFSFPSQESD QTNRGLWLVI 
       260        270        280        290        300
LPPLVMLIVM GVVAIIQPRG IFILVSLAMF MMTLITSTVQ YFRDKNQRKK 
       310        320        330        340        350
REEKRERVYK LYLDNKRKEL QALAEKQKQV LEFHFPSFEQ MKYLTSEISD 
       360        370        380        390        400
RIWEKSLESK DYLQLRLGTG TVPSSYEINM SGGDLANRDI DDLMEKSQHM 
       410        420        430        440        450
QRVYKDIRNA PVTVDLAEGP MGLVGKSQIV KNEIHQLIGQ LSFFNSYHDL 
       460        470        480        490        500
RFVFIFHEEE YKDWEWMKWL PQFQMPHIYA KGFIYNEQTR DQLLSSLYEL 
       510        520        530        540        550
IRERDLEDDK EKLQFKPHFV FVITNQQLIS EHVILEYLEG QHEHLGISTI 
       560        570        580        590        600
VAAETKESLS ENITTLVRYI NEHEGDILIQ KKKAVRIPFR LDHHQREDNE 
       610        620        630        640        650
RFSRTLRTLN HQVGITNSIP ETVSFLELFH AKEVKEIGIQ QRWLTSESSK 
       660        670        680        690        700
SLSVPIGYKG KDDIVYLNLH EKAHGPHGLL AGTTGSGKSE FLQTYILSLA 
       710        720        730        740        750
VHFHPHEAAF LLIDYKGGGM AQPFRNIPHL LGTITNIEGS KNFSMRALAS 
       760        770        780        790        800
IKSELKKRQR LFDQYQVNHI NDYTKLYKQG KAEVAMPHLF LISDEFAELK 
       810        820        830        840        850
SEEPDFIREL VSAARIGRSL GVHLILATQK PGGIIDDQIW SNSRFKVALK 
       860        870        880        890        900
VQDATDSKEI LKNSDAANIT VTGRGYLQVG NNEVYELFQS AWSGAPYLEE 
       910        920        930        940        950
VYGTEDEIAI VTDTGLIPLS EVDTEDNAKK DVQTEIEAVV DEIERIQDEM 
       960        970        980        990       1000
GIEKLPSPWL PPLAERIPRT LFPSNEKDHF HFAYVDEPDL QRQAPIAYKM 
      1010       1020       1030       1040       1050
MEDGNIGIFG SSGYGKSIAA ATFLMSFADV YTPEELHVYI FDFGNGTLLP 
      1060       1070       1080       1090       1100
LAKLPHTADY FLMDQSRKIE KFMIRIKEEI DRRKRLFREK EISHIKMYNA 
      1110       1120       1130       1140       1150
LSEEELPFIF ITIDNFDIVK DEMHELESEF VQLSRDGQSL GIYFMLTATR 
      1160       1170       1180       1190       1200
VNAVRQSLLN NLKTKIVHYL MDQSEGYSIY GRPKFNLEPI PGRVIIQKEE 
      1210       1220       1230       1240       1250
LYFAQMFLPV DADDDIGMFN ELKSDVQKLQ GRFASMEQPA PIPMLPESLS 
      1260       1270       1280       1290       1300
TRELSIRFKL ERKPLSVPIG LHEETVSPVY FDLGKHKHCL ILGQTQRGKT 
      1310       1320       1330       1340       1350
NVLKVMLEHL IDDETEMIGL FDSIDRGLSH YAKESDVSYL ETKEDIEQWI 
      1360       1370       1380       1390       1400
ETAEDIFKTR EAMYVEAVRQ GDAQNLRFSQ VVLMIDGITR FQQTIDTRIQ 
      1410       1420       1430       1440       1450
DRLANFMKSY AHLGFSFIPG GNHSEFSKGY DSLTTEMKQI RHAILLMKKS 
      1460       1470       1480       1490 
EQNVIPLPYQ RQEPEIQPGF GYVVENGKEQ KVQIPLCSAE RESAR
Length:1,495
Mass (Da):171,851
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E302D3699AD9F6D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB04781 differs from that shown. Reason: Frameshift.Curated
The sequence CAB04782 differs from that shown. Reason: Frameshift.Curated
The sequence CAB04782 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119I → V in CAB04782 (PubMed:9168598).Curated1
Sequence conflicti469 – 470WL → CV in CAB04781 (PubMed:9168598).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB15176.2
Z82015 Genomic DNA Translation: CAB04781.1 Frameshift.
Z82015 Genomic DNA Translation: CAB04782.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		D70013

NCBI Reference Sequences

More...RefSeqi		NP_391066.2, NC_000964.3
WP_003243866.1, NZ_JNCM01000033.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAB15176; CAB15176; BSU31875

Database of genes from NCBI RefSeq genomes

More...GeneIDi		936565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bsu:BSU31875

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|224308.179.peg.3453

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB15176.2
Z82015 Genomic DNA Translation: CAB04781.1 Frameshift.
Z82015 Genomic DNA Translation: CAB04782.1 Sequence problems.
PIRiD70013
RefSeqiNP_391066.2, NC_000964.3
WP_003243866.1, NZ_JNCM01000033.1

3D structure databases

SMRiC0SPA7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU31875

Proteomic databases

PRIDEiC0SPA7

Genome annotation databases

EnsemblBacteriaiCAB15176; CAB15176; BSU31875
GeneIDi936565
KEGGibsu:BSU31875
PATRICifig|224308.179.peg.3453

Phylogenomic databases

eggNOGiCOG0433, Bacteria
COG1674, Bacteria
InParanoidiC0SPA7
OMAiWEWMKWL
PhylomeDBiC0SPA7

Enzyme and pathway databases

BioCyciBSUB:BSU31875-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR023839, Firmicutes_EssC_C
IPR022206, Firmicutes_EssC_N
IPR002543, FtsK_dom
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF01580, FtsK_SpoIIIE, 3 hits
PF12538, FtsK_SpoIIIE_N, 1 hit
SUPFAMiSSF52540, SSF52540, 3 hits
TIGRFAMsiTIGR03928, T7_EssCb_Firm, 1 hit
PROSITEiView protein in PROSITE
PS50901, FTSK, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYUKB_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0SPA7
Secondary accession number(s): P71069, Q795L5, Q798N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 5, 2009
Last modified: August 12, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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