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Entry version 63 (08 May 2019)
Sequence version 1 (05 May 2009)
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Protein
Submitted name:

Predicted transmembrane fusion protein, alpha-amylase domain and alpha-1,6-glucosidase domain (Glycogen debranching enzyme activity)

Gene

HRM2_23590

Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseImported, GlycosyltransferaseImported, Hydrolase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
DAUT177437:G1GC3-2350-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
GH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted transmembrane fusion protein, alpha-amylase domain and alpha-1,6-glucosidase domain (Glycogen debranching enzyme activity)Imported (EC:2.4.1.19Imported, EC:3.2.1.33Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:HRM2_23590Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDesulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri177437 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000442 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
177437.HRM2_23590

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 482AamyInterPro annotationAdd BLAST316

Keywords - Domaini

TransmembraneImported

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4108F18 Bacteria
COG0366 LUCA
COG3408 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000023587

Identification of Orthologs from Complete Genome Data

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OMAi
KPAYHNG

Database of Orthologous Groups

More...
OrthoDBi
3019at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.50.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR010401 AGL/Gdb1
IPR032790 GDE_C
IPR006047 Glyco_hydro_13_cat_dom
IPR024742 Glycogen_debranch_N
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10569 PTHR10569, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06202 GDE_C, 1 hit
PF12439 GDE_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00642 Aamy, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C0QFN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVSEMISQL PRPGTSRVMF CGDVLTFTLS IPSNVSGMAW IRTNLGRASI
60 70 80 90 100
ARNEIIDEVD RNEIKLDEAW HDIQMTRQGP AVFAITLPLS ETGHFRAKCF
110 120 130 140 150
FWAEDSHAPV WPPGEDTIIN VEPAGTCCAN IVYNAFVRQF GPTRSQGQPL
160 170 180 190 200
AQEEADCIQC LDKRGYAVIP SSGKFRDLSG EIDFILTHLG CRAIHLLPIH
210 220 230 240 250
PTPTTYGRMG RFGSPYAALN FTDVDPGLAE FDSSATPMEQ FSALVDKIHS
260 270 280 290 300
CAGYLILDIA INHTGWAASI HEKHPEWLVR NKEGEIAVPG AWGVLWADLT
310 320 330 340 350
RLDYSKKALW QYMADIFLLW CTRGVDGFRC DAGYMIPVPA WEYIVAKVKK
360 370 380 390 400
EYPDTLFFLE GLGGPLDATC DILSQANFNW AYSELFQNYD RKAVEAYLPT
410 420 430 440 450
AISISEKFGH MIHFAETHDN QRLAATSTRY AKMRTSLCAL FSVCGGFGFA
460 470 480 490 500
NGVEWFATEK INVHESTCLN WGAKINQTDH IRRLNLILKT HPAFADNVSL
510 520 530 540 550
DLVQTGQGNY LVLCRRIAAT DREIIVVANL DCKMSQTVLW QARHQPEGVL
560 570 580 590 600
FDLVTEQQVV AKLEGEILSV EVEPGRVMAL TRDRQDIKRL QAADLKNDPI
610 620 630 640 650
PWRVVRQKQV ACALKIVTTL AGYGDVSGLD LDYEADALVA DPVAFIRSFN
660 670 680 690 700
PDGNESRVVV WEWNRDVRRQ VMVPHGFFLM VVAPANFRAE IRTRTQGTVR
710 720 730 740 750
TLEQNEALAT RDGRFFAVFL PFDTQGRVME HTLKIRVLGA KGTQKAKAPL
760 770 780 790 800
VFLPGSGTAF VSSTHTRKAI AKNPSLKLLG VNHRGAMMRA FAWWGRLESR
810 820 830 840 850
YDALLAANIQ PDFPEERWMA LTRFRIWATF QGYSRELTLD CLESFTFSYG
860 870 880 890 900
NRGLWRFRLP TSEGSHCPIE IALKMVDQTN AIEMDITRPA GSPRRNPLGD
910 920 930 940 950
DKQVTIIIRP DLEHRSFHET VKAWKGPENQ WKSSISMVSG GFLFAPDPNH
960 970 980 990 1000
CTLGVKASDG TFVWEPEWQY MVHRSLDAER GLDPDSDLFS PGYFIANLGG
1010 1020 1030 1040 1050
RDTIRISARV TCGKGPERDD ILTGSDGPDT EFVRGWPLPE ALTKSLDAFL
1060 1070 1080 1090 1100
VDRAKDRSVI AGYPWFLDWG RDSLIFSRAL IQGERLVDAK KILRLFGRFE
1110 1120 1130 1140 1150
ANGSLPNMIS GNDARNRETS DAPLWFIAAA REVVEKEGGA LLDQTLGGRT
1160 1170 1180 1190 1200
FKEILVSIGD AYVRGTQTGI AMDPETALVF SPSHFTWMDT NFPAGTPREG
1210 1220 1230 1240 1250
YPIEIQALWA YSLEFLAKID PNGTQAWARL ADQVKDSIKT LFFMESRGYF
1260 1270 1280 1290 1300
SDCLHTRGKA PAGSAVVDDA LRPNQLFLIS LGVIRDKDLC IPALEHCMEL
1310 1320 1330 1340 1350
LVPGAIRTLD DSPVDLPLVI EGPTGPLNDP HRPYWGHYMG DEDTRRKPAY
1360 1370 1380 1390 1400
HNGTAWTWVF PVFCEAWAET FGSKGAMTGI SWLTSSVKLM EQGVAGFVPE
1410 1420 1430
IVDGDAPHAP RGCDAQAWGA SELYRVWHKL SLRS
Length:1,434
Mass (Da):160,184
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06E33D6F69286B78
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP001087 Genomic DNA Translation: ACN15454.1

NCBI Reference Sequences

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RefSeqi
WP_015904222.1, NC_012108.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACN15454; ACN15454; HRM2_23590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dat:HRM2_23590

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001087 Genomic DNA Translation: ACN15454.1
RefSeqiWP_015904222.1, NC_012108.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi177437.HRM2_23590

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACN15454; ACN15454; HRM2_23590
KEGGidat:HRM2_23590

Phylogenomic databases

eggNOGiENOG4108F18 Bacteria
COG0366 LUCA
COG3408 LUCA
HOGENOMiHOG000023587
OMAiKPAYHNG
OrthoDBi3019at2

Enzyme and pathway databases

BioCyciDAUT177437:G1GC3-2350-MONOMER

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR010401 AGL/Gdb1
IPR032790 GDE_C
IPR006047 Glyco_hydro_13_cat_dom
IPR024742 Glycogen_debranch_N
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10569 PTHR10569, 1 hit
PfamiView protein in Pfam
PF06202 GDE_C, 1 hit
PF12439 GDE_N, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF51445 SSF51445, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC0QFN6_DESAH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0QFN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 8, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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