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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

HCBG_01775

Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei246NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi217 – 221ATPUniRule annotation5
Nucleotide bindingi236 – 245ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:HCBG_01775
OrganismiAjellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri447093 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
Proteomesi
  • UP000001631 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161781 – 368ATP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST368

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliC0NFV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 359YjeF C-terminalUniRule annotationAdd BLAST357

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 179NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

InParanoidiC0NFV9
OrthoDBiEOG092C4N4W

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

C0NFV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPSKKLLA NVRRIVPPML ERFHKGQLGR VAVIGGSAEC APHISLQWHL
60 70 80 90 100
QGLSHVICEP SSATVIKSYS PNLMVHPILQ SSNTVSSFSN SPLPHPHARA
110 120 130 140 150
LAEPVLSFLS RLHVLVIGPG LGRDPVTQEI VTEIIKEARS REIPLVLDAD
160 170 180 190 200
ALLLVQEHPD LIHGYTECIL TPNVVEFARL AKALRADVSS MPDSDAGKSE
210 220 230 240 250
ACKRLSNALG GVTIIQKGPH DTISNGMVNI VCDVRGGLKR SGGQGDTLTG
260 270 280 290 300
SLGTLLAWRK AYHEGLWDTG ESEASGGREL SRQDIEEDLS ICGYESGDDG
310 320 330 340 350
ERDGDKPKKK LSRPATLLLV AWAGSAITRE CSRRAFMAKG RSMQASDLTD
360
EVHGSFLDLI GEPEGTKL
Length:368
Mass (Da):39,605
Last modified:May 5, 2009 - v1
Checksum:iB9E5EF76856DBCF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG663364 Genomic DNA Translation: EEH10130.1

Genome annotation databases

EnsemblFungiiEEH10130; EEH10130; HCBG_01775

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG663364 Genomic DNA Translation: EEH10130.1

3D structure databases

ProteinModelPortaliC0NFV9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEH10130; EEH10130; HCBG_01775

Phylogenomic databases

InParanoidiC0NFV9
OrthoDBiEOG092C4N4W

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNRD_AJECG
AccessioniPrimary (citable) accession number: C0NFV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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