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Protein
Submitted name:

Toll-like receptor 10

Gene

Tlr10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lipopeptide binding Source: GO_Central
  • Toll-like receptor 2 binding Source: GO_Central
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 10Imported
Gene namesi
Name:Tlr10Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1311569 Tlr10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei578 – 599HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliC0LSK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 778TIRInterPro annotationAdd BLAST147

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
HOGENOMiHOG000008676
KOiK10171
PhylomeDBiC0LSK8

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027182 TLR10
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF23 PTHR24365:SF23, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

C0LSK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLISSIYTL YNIIMSTEAW APRPTDEREL ISNYSNMALR KVPPDVTPAT
60 70 80 90 100
TILDLSYNLL YQFQSSDFHS FSKLRFLILC HNSIQQLDTK IFDLNKELSY
110 120 130 140 150
LDLSYNRLQS ITWSSLVDLR HLDLSFNDFD TLPACEEIGN MRHLETLGLS
160 170 180 190 200
GAKIQRSDLQ KIANLQFSTV FIGLNTLSHY EEGSLPVLNT TVLHIVLPMA
210 220 230 240 250
ANFWVLLCDG MKTSKVVEMS NIGGKSQFVS YETPRTLSVE NTKASTLIFH
260 270 280 290 300
KVDLLWDDLL HVFQFVWQTS VECFQIQDLT FGGMASRDHS SFDYSNTVMK
310 320 330 340 350
AVILESIHFR IFFIPQNKIY LFFTQMDLEN LTISDAQMPH LLFPSHPQSF
360 370 380 390 400
QHLNFANNIL TDDLFKNPIQ MPYLKTLVLR GNQLETLSLV SLFANHTSLL
410 420 430 440 450
HLDLSQNLLQ HGNGEKCMWP DTLILLNLSS NKFDGSVFRC LPKSIQTLDL
460 470 480 490 500
NNNKIRAVPK EIIYLKSLRE LSIAFNFLTD LPGCDHFKRL SSLNIEMNLI
510 520 530 540 550
LSPSLDFFQS CQEVKTLNAG RNPFRCICEF RDFIWLEKHS KGLMSEWPDS
560 570 580 590 600
YACEYPLSLK GTPLKDVYLP ELACNTTLLI VTIVLVILVL GLVVAFCILK
610 620 630 640 650
FDMLWYLRVL AQCIRTQHRV RKTVREERKR SVQFHAFISY AAHDSVWVKN
660 670 680 690 700
ELIPNLETED GSVLLCLPER NFDPDRSIAE NIISCTEKSY KSIFVLSPNF
710 720 730 740 750
VQNGWCHNEL YLAHHNPFRD NYDYIIPILL EPIPSYCVPT KFPKLKALLE
760 770 780 790 800
KKVYLEWPKD RRKHGLFWAN LRAAINVNLS DTRGRCELQT FTKPNADCQG
810
STISLVRTDS F
Length:811
Mass (Da):93,408
Last modified:May 5, 2009 - v1
Checksum:iC43C18C480F82141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ755908 mRNA Translation: ACN78428.1
RefSeqiNP_001139507.1, NM_001146035.1
UniGeneiRn.222113

Genome annotation databases

GeneIDi305355
KEGGirno:305355

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ755908 mRNA Translation: ACN78428.1
RefSeqiNP_001139507.1, NM_001146035.1
UniGeneiRn.222113

3D structure databases

ProteinModelPortaliC0LSK8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi305355
KEGGirno:305355

Organism-specific databases

CTDi81793
RGDi1311569 Tlr10

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
HOGENOMiHOG000008676
KOiK10171
PhylomeDBiC0LSK8

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027182 TLR10
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF23 PTHR24365:SF23, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC0LSK8_RAT
AccessioniPrimary (citable) accession number: C0LSK8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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