UniProtKB - C0LJL5 (C0LJL5_HE71)
Genome polyprotein
Functioni
Catalytic activityi
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H+ + phosphateUniRule annotationARBA annotationEC:3.6.1.15UniRule annotation EC:3.6.1.15ARBA annotation
- EC:2.7.7.48UniRule annotation
- Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.UniRule annotation EC:3.4.22.28
- Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.UniRule annotation EC:3.4.22.29
- Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.ARBA annotation EC:3.4.22.29
Cofactori
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: UniProtKB-EC
- ion channel activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: InterPro
- structural molecule activity Source: InterPro
GO - Biological processi
- endocytosis involved in viral entry into host cell Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- pore formation by virus in membrane of host cell Source: UniProtKB-KW
- pore-mediated entry of viral genome into host cell Source: UniProtKB-KW
- protein complex oligomerization Source: UniProtKB-KW
- RNA-protein covalent cross-linking Source: UniProtKB-KW
- suppression by virus of host gene expression Source: UniProtKB-KW
- suppression by virus of host MDA-5 activity Source: UniProtKB-KW
- suppression by virus of host mRNA export from nucleus Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Genome polyproteinUniRule annotationCleaved into the following 17 chains: P3UniRule annotation Protein 3ABUniRule annotation P2UniRule annotation P1UniRule annotation Capsid protein VP0UniRule annotation Alternative name(s): VP4-VP2UniRule annotation Capsid protein VP4UniRule annotation Alternative name(s): P1AUniRule annotation Virion protein 4UniRule annotation Capsid protein VP2UniRule annotation Alternative name(s): P1BUniRule annotation Virion protein 2UniRule annotation Capsid protein VP3UniRule annotation Alternative name(s): P1CUniRule annotation Virion protein 3UniRule annotation Capsid protein VP1UniRule annotation Alternative name(s): P1DUniRule annotation Virion protein 1UniRule annotation Alternative name(s): Picornain 2AUniRule annotation Protein 2AUniRule annotation Protein 2BUniRule annotation Short name: P2BUniRule annotation Protein 3AUniRule annotation Short name: P3AUniRule annotation Viral protein genome-linkedUniRule annotation Short name: VPgUniRule annotation Alternative name(s): Protein 3BUniRule annotation Short name: P3BUniRule annotation Protease 3CUniRule annotation Short name: P3CUniRule annotation RNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.48UniRule annotation) Short name: RdRpUniRule annotation Alternative name(s): 3D polymeraseUniRule annotation Short name: 3DpolUniRule annotation Protein 3DUniRule annotation Short name: 3DUniRule annotation |
Organismi | Human enterovirus 71 (EV71) (EV-71)Imported |
Taxonomic identifieri | 39054 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Picornavirales › Picornaviridae › Enterovirus › Enterovirus A |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- Host cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- Host nucleus ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- Nucleus ARBA annotation
- Virion ARBA annotation
GO - Cellular componenti
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- host cell cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- integral to membrane of host cell Source: UniProtKB-KW
- T=pseudo3 icosahedral viral capsid Source: UniProtKB-KW
Keywords - Cellular componenti
Capsid protein, Host cytoplasmUniRule annotationARBA annotation, Host cytoplasmic vesicleUniRule annotationARBA annotation, Host membraneUniRule annotationARBA annotation, Host nucleusARBA annotation, Membrane, T=pseudo3 icosahedral capsid proteinUniRule annotationARBA annotation, VirionPTM / Processingi
Keywords - PTMi
Covalent protein-RNA linkageUniRule annotationARBA annotation, Lipoprotein, MyristateUniRule annotationARBA annotation, PhosphoproteinARBA annotationInteractioni
Subunit structurei
Capsid protein VP1:
Interacts with capsid protein VP0, and capsid protein VP3 to form heterotrimeric protomers. Five protomers subsequently associate to form pentamers which serve as building blocks for the capsid.
Interacts with capsid protein VP2, capsid protein VP3 and capsid protein VP4 following cleavage of capsid protein VP0.
UniRule annotationHomodimer.
ARBA annotationInteracts with RNA-directed RNA polymerase.
ARBA annotationInteracts with Viral protein genome-linked and with protein 3CD.
ARBA annotationInteracts with capsid protein VP0 and capsid protein VP1 to form heterotrimeric protomers (By similarity). Five protomers subsequently associate to form pentamers which serve as building blocks for the capsid (By similarity).
Interacts with capsid protein VP4 in the mature capsid (By similarity).
Interacts with protein 2C; this interaction may be important for virion morphogenesis.
ARBA annotationInteracts with capsid protein VP1 and capsid protein VP3 to form heterotrimeric protomers.
ARBA annotationInteracts with protein 3CD.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1216 – 1374 | SF3 helicaseInterPro annotationAdd BLAST | 159 | |
Domaini | 1549 – 1727 | Peptidase C3InterPro annotationAdd BLAST | 179 | |
Domaini | 1958 – 2073 | RdRp catalyticInterPro annotationAdd BLAST | 116 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1164 – 1184 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatUniRule annotationARBA annotation, Zinc-fingerARBA annotationFamily and domain databases
CDDi | cd00205, rhv_like, 3 hits |
Gene3Di | 1.10.10.870, 1 hit 2.40.10.10, 4 hits 2.60.120.20, 3 hits 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR043502, DNA/RNA_pol_sf IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR027417, P-loop_NTPase IPR014838, P3A IPR036203, P3A_soluble_dom IPR044067, PCV_3C_PRO IPR000081, Peptidase_C3 IPR000199, Peptidase_C3A/C3B_picornavir IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR003138, Pico_P1A IPR002527, Pico_P2B IPR001676, Picornavirus_capsid IPR043128, Rev_trsase/Diguanyl_cyclase IPR033703, Rhv-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR029053, Viral_coat |
Pfami | View protein in Pfam PF08727, P3A, 1 hit PF00548, Peptidase_C3, 1 hit PF02226, Pico_P1A, 1 hit PF00947, Pico_P2A, 1 hit PF01552, Pico_P2B, 1 hit PF00680, RdRP_1, 1 hit PF00073, Rhv, 3 hits PF00910, RNA_helicase, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50494, SSF50494, 2 hits SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit SSF89043, SSF89043, 1 hit |
PROSITEi | View protein in PROSITE PS51874, PCV_3C_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGSQVSTQRS GSHENSNSAT EGSTINYTTI NYYKVSYAAT AGKQGLKQDP
60 70 80 90 100
DKFANPVKDI FTEMAAPLKS PSAEACGYSD RVAQLTIGNS TITTQEAANI
110 120 130 140 150
IVGYGEWPSY CSDSDATAVD KPTRPDVSVN RFYTLDTKLW EKSSKGWYWK
160 170 180 190 200
FPDVLTETGV FGQNAQFHYL YRSGFCIHVQ CNASKFHQGV LLVAVLPEYV
210 220 230 240 250
IGTVAGGTGT EDSHPPYKQT QPGADGFELQ HPYVLDAGIP ISQLTVCPHQ
260 270 280 290 300
WINLRTNNCA TIIVPYINAL PFDSALNHCN FGLLVVPISP LDYDQGATPV
310 320 330 340 350
IPITITLAPM CSEFAGLRQA VTQGFPTELK PGTNQFLTTD DGVSAPILPN
360 370 380 390 400
FHPTPCIHIP GEVRNLLELC QVETILEVNN VPTNATSLME RLRFPVSAQA
410 420 430 440 450
GKGELCAVFR ADPGRNGPWQ STLLGQLCGY YTQWSGSLEV TFMFTGSFMA
460 470 480 490 500
IGKMLIAYTP PGGPLPKDRA TAMLGTHVIW DFWLQSSVTL VIPWISNTHY
510 520 530 540 550
RAHARDGVFD YYTTGLVSIW YQTNYVVPIG APNTAYIIAL AAAQKNFTMK
560 570 580 590 600
LCKDASDILQ TGTIQGDRVA DVIESSIGDS VSRALTHALP APTGQNTQVS
610 620 630 640 650
SHRLDTGKVP ALQAAEIGAS SNASDESMIE TRCVLNSHST AETTLDSFFS
660 670 680 690 700
RAGLVGEIDL PLEGTTNPNG YANWDIDITG YAQMRRKVEL FTYMRFDAEF
710 720 730 740 750
TFVACTPTGE VVPQLLQYMF VPPGAPKPDS RESLAWQTAT NPSVFVKLSD
760 770 780 790 800
PPAQVSVPFM SPASAYQWFY DGYPTFGEHK QEKDLEYGAC PNNMMGTFSV
810 820 830 840 850
RTVGTSKSKY PLVVRIYMRM KHVRAWIPRP MRNQNYLFKA NPNYAGNSIK
860 870 880 890 900
PTGASRTAIT TLGKFGQQSG AIYVGNFRVV NRHLATHNDW ANLVWEDSSR
910 920 930 940 950
DLLVSSTTAQ GCDTIARCDC QTGVYYCNSR RKHYPVSFSK PSLIYVEASE
960 970 980 990 1000
YYPARYQSHL MLAQGHSEPG DCGGILRCQH GVVGIVSTGG NGLVGFADVR
1010 1020 1030 1040 1050
DLLWLDEEAM EQGVSDYIKG LGDAFGTGFT DAVSREVEAL KNYLIGSEGA
1060 1070 1080 1090 1100
VEKILKNLVK LISALVIVIR SDYDMVTLTA TLALIGCHGS PWAWIKAKTA
1110 1120 1130 1140 1150
SILGIPIAQK QSASWLKKFN DMANAAKGLE WVSNKISKFI DWLKEKIVPA
1160 1170 1180 1190 1200
AKEKVEFLNN LKQLPLLENQ ISNLEQSAAS QEDLEVMFGN VSYLAHFCRK
1210 1220 1230 1240 1250
FQPLYATEAK RVYALEKRMN NYMQFKSKHR IEPVCLIIRG SPGTGKSLAT
1260 1270 1280 1290 1300
GIIARAIADK YHSSVYSLPP DPDHFDGYKQ QVVTVMDDLC QNPDGKDMSL
1310 1320 1330 1340 1350
FCQMVSTVDF IPPMASLEEK GVSFTSKFVI ASTNASNIIV PTVSDSDAIR
1360 1370 1380 1390 1400
RRFYMDCDIE VTDSYKTDLG RLDAGRAAKL CSENNTANFK RCSPLVCGKA
1410 1420 1430 1440 1450
IQLRDRKSKV RYSVDTVVSE LIREYSNRSA IGNTIEALFQ GPPKFRPIRI
1460 1470 1480 1490 1500
SLEEKPAPDA ISDLLASVDS EEVRQYCRDQ GWIIPETPTN VERHLNRAVL
1510 1520 1530 1540 1550
VMQSIATVVA VVSLVYVIYK LFAGFQGAYS GAPKQVLKKP ALRTATVQGP
1560 1570 1580 1590 1600
SLDFALSLLR RNVRQVQTDQ GHFTMLGVRD RLAVLPRHSQ PGKTIWIEHK
1610 1620 1630 1640 1650
LVNVLDAVEL VDEQGVNLEL TLITLDTNEK FRDITKFIPE SISTASDATL
1660 1670 1680 1690 1700
VINTEHMPSM FVPVGDVVQY GFLNLSGKPT HRTMMYNFPT KAGQCGGVVT
1710 1720 1730 1740 1750
SVGKVIGIHI GGNGRQGFCA GLKRSYFASE QGEIQWVKPN KETGRLNING
1760 1770 1780 1790 1800
PTRTKLEPSV FHDVFEGSRE PAVLHSKDPR LEVDFEQALF SKYVGNTLHE
1810 1820 1830 1840 1850
PDEYIKEAAL HYANQLKQLE INTSQMSMEE ACYGTENLEA IDLHTSAGYP
1860 1870 1880 1890 1900
YGALGIKKRD ILDPTTRDVS KMKLYMDKYG LDLPYSTYVK DELRSVDKIK
1910 1920 1930 1940 1950
KGKSRLIEAS SLNDSVCLRM AFGHLYEAFH ANPRTITGSA VGCNPDTFWS
1960 1970 1980 1990 2000
KLPILLPGSL FAFDYSGYDA SLSPVWFRAL ELVLREIGYS EGAVSLIEGI
2010 2020 2030 2040 2050
NHTHHVYRNK TYCVLGGMPS GCSGTSIFNS MINNIIIRAL LIKTFKGIDL
2060 2070 2080 2090 2100
DELNMVAYGD DVLASYPFPI DCLELAKTGK EYGLTMTPAD KSPCFNEVNW
2110 2120 2130 2140 2150
GNATFLKRGF LPDEQFPFLI HPTMPMREIH ESIRWTKDAR NTQDHVRSLC
2160 2170 2180 2190
LLAWHNGKQE YEKFVSTIRS VPVGRALAIP NYENLRRNWL ELF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ713137 Genomic RNA Translation: ACN59569.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ713137 Genomic RNA Translation: ACN59569.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
CDDi | cd00205, rhv_like, 3 hits |
Gene3Di | 1.10.10.870, 1 hit 2.40.10.10, 4 hits 2.60.120.20, 3 hits 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR043502, DNA/RNA_pol_sf IPR000605, Helicase_SF3_ssDNA/RNA_vir IPR014759, Helicase_SF3_ssRNA_vir IPR027417, P-loop_NTPase IPR014838, P3A IPR036203, P3A_soluble_dom IPR044067, PCV_3C_PRO IPR000081, Peptidase_C3 IPR000199, Peptidase_C3A/C3B_picornavir IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR003138, Pico_P1A IPR002527, Pico_P2B IPR001676, Picornavirus_capsid IPR043128, Rev_trsase/Diguanyl_cyclase IPR033703, Rhv-like IPR001205, RNA-dir_pol_C IPR007094, RNA-dir_pol_PSvirus IPR029053, Viral_coat |
Pfami | View protein in Pfam PF08727, P3A, 1 hit PF00548, Peptidase_C3, 1 hit PF02226, Pico_P1A, 1 hit PF00947, Pico_P2A, 1 hit PF01552, Pico_P2B, 1 hit PF00680, RdRP_1, 1 hit PF00073, Rhv, 3 hits PF00910, RNA_helicase, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF50494, SSF50494, 2 hits SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit SSF89043, SSF89043, 1 hit |
PROSITEi | View protein in PROSITE PS51874, PCV_3C_PRO, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit PS51218, SF3_HELICASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C0LJL5_HE71 | |
Accessioni | C0LJL5Primary (citable) accession number: C0LJL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 5, 2009 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |