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Entry version 82 (18 Sep 2019)
Sequence version 1 (05 May 2009)
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Protein

LRR receptor-like serine/threonine-protein kinase EFR

Gene

EFR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Reduces transformation by Rhizobium radiobacter probably by inducing plant defense during the interaction. Binding to the effector AvrPto1 from P.syringae blocks the downstream plant immune response while interaction with hopD2 decreases the phosphorylation level of EFR upon elf18 treatment. Specific endoplasmic reticulum quality control components (ERD2B, CRT3, UGGT and STT3A) are required for the biogenesis of EFR.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei741ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei849Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi718 – 726ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processPlant defense
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LRR receptor-like serine/threonine-protein kinase EFR (EC:2.7.11.1)
Alternative name(s):
Elongation factor Tu receptor
Short name:
EF-Tu receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EFR
Ordered Locus Names:At5g20480
ORF Names:F7C8.70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G20480

The Arabidopsis Information Resource

More...
TAIRi
locus:2149922 AT5G20480

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 653ExtracellularSequence analysisAdd BLAST629
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 1031CytoplasmicSequence analysisAdd BLAST357

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Enhanced susceptibility to R.radiobacter.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi76 – 77IS → AA: No effect on elf18 sensitivity. 1 Publication2
Mutagenesisi81 – 82GG → AA: No effect on elf18 sensitivity. 1 Publication2
Mutagenesisi103 – 106NLAD → ALAA: Insensitive to elf18. 1 Publication4
Mutagenesisi274 – 275GT → AA: No effect on elf18 sensitivity. 1 Publication2
Mutagenesisi293 – 294ER → AA: No effect on elf18 sensitivity. 1 Publication2
Mutagenesisi298 – 299SS → AA: No effect on elf18 sensitivity. 1 Publication2
Mutagenesisi317 – 318WW → AA: Decreased elf18 sensitivity. 1 Publication2
Mutagenesisi347 – 348EY → AA: Decreased elf18 sensitivity. 1 Publication2
Mutagenesisi373 – 375SLF → ALA: No effect on elf18 sensitivity. 1 Publication3
Mutagenesisi397 – 399ELS → ALA: Decreased elf18 sensitivity. 1 Publication3
Mutagenesisi447 – 449HLN → ALA: Insensitive to elf18. 1 Publication3
Mutagenesisi469 – 473DLWMD → ALWMA: Insensitive to elf18. 1 Publication5
Mutagenesisi564 – 568NVDFS → AVDFA: Decreased elf18 sensitivity. 1 Publication5
Mutagenesisi588 – 590NLN → ALA: Insensitive to elf18. 1 Publication3
Mutagenesisi702Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi791Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi836Y → F: Loss of elf18-triggered immunity, but no effect on the kinase activity. 1 Publication1
Mutagenesisi849D → N: Loss of kinase activity. 1 Publication1
Mutagenesisi875Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi877Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi897Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi902Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi915Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi939Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi944Y → F: No effect on elf18-triggered immunity. 1 Publication1
Mutagenesisi979Y → F: No effect on elf18-triggered immunity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038750825 – 1031LRR receptor-like serine/threonine-protein kinase EFRAdd BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei709PhosphothreonineBy similarity1
Modified residuei791PhosphotyrosineBy similarity1
Modified residuei836Phosphotyrosine1 Publication1
Modified residuei897Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated after elicitation with elfl18. Autophosphorylation is inhibited by the binding with avrPto1. Phosphorylation at T-836 is required for immune signaling.1 Publication
Polyubiquitinated at the kinase domain mediated by P.syringae AvrPtoB.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
C0LGT6

PRoteomics IDEntifications database

More...
PRIDEi
C0LGT6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
C0LGT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
C0LGT6 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to Pseudomonas syringae AvrPto1 and (via the kinase and cytoplasmic domains) to hopD2.

Interacts with SERK3/BAK1, SERK4/BKK1, SERK1 and SERK2 in a specific ligand-induced manner. Binds to IOS1 (PubMed:27317676).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
17446, 23 interactors

Database of interacting proteins

More...
DIPi
DIP-61674N

Protein interaction database and analysis system

More...
IntActi
C0LGT6, 28 interactors

Molecular INTeraction database

More...
MINTi
C0LGT6

STRING: functional protein association networks

More...
STRINGi
3702.AT5G20480.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C0LGT6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati98 – 120LRR 1Add BLAST23
Repeati122 – 144LRR 2Add BLAST23
Repeati146 – 168LRR 3Add BLAST23
Repeati170 – 193LRR 4Add BLAST24
Repeati194 – 216LRR 5Add BLAST23
Repeati218 – 240LRR 6Add BLAST23
Repeati242 – 264LRR 7Add BLAST23
Repeati267 – 289LRR 8Add BLAST23
Repeati291 – 312LRR 9Add BLAST22
Repeati315 – 335LRR 10Add BLAST21
Repeati345 – 368LRR 11Add BLAST24
Repeati370 – 392LRR 12Add BLAST23
Repeati394 – 416LRR 13Add BLAST23
Repeati418 – 440LRR 14Add BLAST23
Repeati442 – 464LRR 15Add BLAST23
Repeati466 – 487LRR 16Add BLAST22
Repeati490 – 512LRR 17Add BLAST23
Repeati514 – 536LRR 18Add BLAST23
Repeati538 – 560LRR 19Add BLAST23
Repeati561 – 584LRR 20Add BLAST24
Repeati585 – 597LRR 21Add BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini712 – 1001Protein kinasePROSITE-ProRule annotationAdd BLAST290

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The last two LRR (561-597) are necessary for elf18 binding and functionality.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH5R Eukaryota
COG0515 LUCA
COG4886 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116551

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
C0LGT6

KEGG Orthology (KO)

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KOi
K13428

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMVFFQI

Database of Orthologous Groups

More...
OrthoDBi
335055at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C0LGT6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 2 hits
PF08263 LRRNT_2, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSFSLVFN ALTLLLQVCI FAQARFSNET DMQALLEFKS QVSENNKREV
60 70 80 90 100
LASWNHSSPF CNWIGVTCGR RRERVISLNL GGFKLTGVIS PSIGNLSFLR
110 120 130 140 150
LLNLADNSFG STIPQKVGRL FRLQYLNMSY NLLEGRIPSS LSNCSRLSTV
160 170 180 190 200
DLSSNHLGHG VPSELGSLSK LAILDLSKNN LTGNFPASLG NLTSLQKLDF
210 220 230 240 250
AYNQMRGEIP DEVARLTQMV FFQIALNSFS GGFPPALYNI SSLESLSLAD
260 270 280 290 300
NSFSGNLRAD FGYLLPNLRR LLLGTNQFTG AIPKTLANIS SLERFDISSN
310 320 330 340 350
YLSGSIPLSF GKLRNLWWLG IRNNSLGNNS SSGLEFIGAV ANCTQLEYLD
360 370 380 390 400
VGYNRLGGEL PASIANLSTT LTSLFLGQNL ISGTIPHDIG NLVSLQELSL
410 420 430 440 450
ETNMLSGELP VSFGKLLNLQ VVDLYSNAIS GEIPSYFGNM TRLQKLHLNS
460 470 480 490 500
NSFHGRIPQS LGRCRYLLDL WMDTNRLNGT IPQEILQIPS LAYIDLSNNF
510 520 530 540 550
LTGHFPEEVG KLELLVGLGA SYNKLSGKMP QAIGGCLSME FLFMQGNSFD
560 570 580 590 600
GAIPDISRLV SLKNVDFSNN NLSGRIPRYL ASLPSLRNLN LSMNKFEGRV
610 620 630 640 650
PTTGVFRNAT AVSVFGNTNI CGGVREMQLK PCIVQASPRK RKPLSVRKKV
660 670 680 690 700
VSGICIGIAS LLLIIIVASL CWFMKRKKKN NASDGNPSDS TTLGMFHEKV
710 720 730 740 750
SYEELHSATS RFSSTNLIGS GNFGNVFKGL LGPENKLVAV KVLNLLKHGA
760 770 780 790 800
TKSFMAECET FKGIRHRNLV KLITVCSSLD SEGNDFRALV YEFMPKGSLD
810 820 830 840 850
MWLQLEDLER VNDHSRSLTP AEKLNIAIDV ASALEYLHVH CHDPVAHCDI
860 870 880 890 900
KPSNILLDDD LTAHVSDFGL AQLLYKYDRE SFLNQFSSAG VRGTIGYAAP
910 920 930 940 950
EYGMGGQPSI QGDVYSFGIL LLEMFSGKKP TDESFAGDYN LHSYTKSILS
960 970 980 990 1000
GCTSSGGSNA IDEGLRLVLQ VGIKCSEEYP RDRMRTDEAV RELISIRSKF
1010 1020 1030
FSSKTTITES PRDAPQSSPQ EWMLNTDMHT M
Length:1,031
Mass (Da):113,353
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0E0AE671DA9124D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti893G → L in BAE98400 (Ref. 5) Curated1
Sequence conflicti929K → E in AAL77697 (PubMed:14593172).Curated1
Sequence conflicti929K → E in AAO64755 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF296833 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92850.1
CP002688 Genomic DNA Translation: ANM70991.1
AY075690 mRNA Translation: AAL77697.1
BT005820 mRNA Translation: AAO64755.1
FJ708780 mRNA Translation: ACN59371.1
AK226237 mRNA Translation: BAE98400.1

NCBI Reference Sequences

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RefSeqi
NP_001318610.1, NM_001343669.1
NP_197548.1, NM_122055.5

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT5G20480.1; AT5G20480.1; AT5G20480
AT5G20480.2; AT5G20480.2; AT5G20480

Database of genes from NCBI RefSeq genomes

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GeneIDi
832170

Gramene; a comparative resource for plants

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Gramenei
AT5G20480.1; AT5G20480.1; AT5G20480
AT5G20480.2; AT5G20480.2; AT5G20480

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT5G20480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296833 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92850.1
CP002688 Genomic DNA Translation: ANM70991.1
AY075690 mRNA Translation: AAL77697.1
BT005820 mRNA Translation: AAO64755.1
FJ708780 mRNA Translation: ACN59371.1
AK226237 mRNA Translation: BAE98400.1
RefSeqiNP_001318610.1, NM_001343669.1
NP_197548.1, NM_122055.5

3D structure databases

SMRiC0LGT6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi17446, 23 interactors
DIPiDIP-61674N
IntActiC0LGT6, 28 interactors
MINTiC0LGT6
STRINGi3702.AT5G20480.1

PTM databases

iPTMnetiC0LGT6

Proteomic databases

PaxDbiC0LGT6
PRIDEiC0LGT6

Genome annotation databases

EnsemblPlantsiAT5G20480.1; AT5G20480.1; AT5G20480
AT5G20480.2; AT5G20480.2; AT5G20480
GeneIDi832170
GrameneiAT5G20480.1; AT5G20480.1; AT5G20480
AT5G20480.2; AT5G20480.2; AT5G20480
KEGGiath:AT5G20480

Organism-specific databases

AraportiAT5G20480
TAIRilocus:2149922 AT5G20480

Phylogenomic databases

eggNOGiENOG410IH5R Eukaryota
COG0515 LUCA
COG4886 LUCA
HOGENOMiHOG000116551
InParanoidiC0LGT6
KOiK13428
OMAiQMVFFQI
OrthoDBi335055at2759
PhylomeDBiC0LGT6

Miscellaneous databases

Protein Ontology

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PROi
PR:C0LGT6

Gene expression databases

GenevisibleiC0LGT6 AT

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR013210 LRR_N_plant-typ
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00560 LRR_1, 2 hits
PF13855 LRR_8, 2 hits
PF08263 LRRNT_2, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFR_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0LGT6
Secondary accession number(s): Q0WWU8, Q8S9I3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: September 18, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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