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Entry version 90 (23 Feb 2022)
Sequence version 1 (05 May 2009)
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Protein

LRR receptor-like serine/threonine-protein kinase RGI3

Gene

RGI3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with RGI1, RGI2, RGI4 and RGI5, acts as receptor of RGF peptides (e.g. RGF1, GLV5/CLEL1/RGF2, GLV7/CLEL3/RGF3, GLV3/RGF4, GLV10/CLEL7/RGF5 and RGF10/CLELN), peptide hormones which maintain the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT, e.g. PLT1 and PLT2) (PubMed:27229311, PubMed:27229312, PubMed:27001831).

Links RGF peptides signal with their downstream components (PubMed:27229311, PubMed:27001831).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei788ATPPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei788Essential for autophosphorylation activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei883Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi766 – 774ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LRR receptor-like serine/threonine-protein kinase RGI3Curated (EC:2.7.11.1PROSITE-ProRule annotation)
Alternative name(s):
Protein RECEPTOR OF RGF1 11 Publication
Protein RGF1 INSENSITIVE 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGI31 Publication
Synonyms:RGFR11 Publication, RGFR31 Publication
Ordered Locus Names:At4g26540Imported
ORF Names:M3E9.30Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G26540

The Arabidopsis Information Resource

More...
TAIRi
locus:2131518, AT4G26540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 703ExtracellularSequence analysisAdd BLAST679
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Topological domaini725 – 1091CytoplasmicSequence analysisAdd BLAST367

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Smaller root meristem size and fewer root meristematic cortex cells, associated with shorter roots and a slighty reduced sensitivity to RGF1 (PubMed:27229311). Quintuple mutants rgi1 rgi2 rgi3 rgi4 rgi5 display a consistent short primary root phenotype with a small size of meristem associated with a total insensitivity to RGF1 and undetectable levels of PLT1 and PLT2 (PubMed:27229312). The triple mutant missing RGI1, RGI2 and RGI3 is insensitive to externally applied RGF peptides (e.g. RGF1 and RGF2) and has short roots characterized by a strong decrease in meristematic cell number and declined levels of PLT1 and PLT2 at the root tip (PubMed:27001831).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038755325 – 1091LRR receptor-like serine/threonine-protein kinase RGI3Add BLAST1067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 64By similarity
Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi163N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi356N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi431N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi452N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi604N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi651N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi697N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei831PhosphotyrosineBy similarity1
Modified residuei870PhosphotyrosineBy similarity1
Modified residuei933PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated and ubiquitinated upon interaction with RGF1, thus leading to activation a subsequent degradation.By similarity
Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
C0LGR3

PRoteomics IDEntifications database

More...
PRIDEi
C0LGR3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
236934

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
C0LGR3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in roots.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In roots, detected in the more basal region of the elongation zone and the differentiation zone, mainly restricted to columella, transition zone and root stem cell niche.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
C0LGR3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
C0LGR3, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to RGF peptides such as RGF1, GLV5/CLEL1/RGF2, GLV7/CLEL3/RGF3, GLV3/RGF4, GLV10/CLEL7/RGF5 and RGF10/CLELN; these interactions trigger the formation of heterodimers with SERK1, SERK2 or BAK1/SERK3 via LRR regions.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
14047, 44 interactors

Protein interaction database and analysis system

More...
IntActi
C0LGR3, 44 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G26540.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11091
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C0LGR3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 56LRR 1Sequence analysisAdd BLAST24
Repeati67 – 91LRR 2Sequence analysisAdd BLAST25
Repeati92 – 115LRR 3Sequence analysisAdd BLAST24
Repeati116 – 140LRR 4Sequence analysisAdd BLAST25
Repeati142 – 166LRR 5Sequence analysisAdd BLAST25
Repeati168 – 188LRR 6Sequence analysisAdd BLAST21
Repeati190 – 213LRR 7Sequence analysisAdd BLAST24
Repeati214 – 237LRR 8Sequence analysisAdd BLAST24
Repeati239 – 261LRR 9Sequence analysisAdd BLAST23
Repeati262 – 285LRR 10Sequence analysisAdd BLAST24
Repeati287 – 309LRR 11Sequence analysisAdd BLAST23
Repeati311 – 332LRR 12Sequence analysisAdd BLAST22
Repeati333 – 357LRR 13Sequence analysisAdd BLAST25
Repeati359 – 383LRR 14Sequence analysisAdd BLAST25
Repeati385 – 405LRR 15Sequence analysisAdd BLAST21
Repeati406 – 429LRR 16Sequence analysisAdd BLAST24
Repeati431 – 453LRR 17Sequence analysisAdd BLAST23
Repeati454 – 477LRR 18Sequence analysisAdd BLAST24
Repeati478 – 501LRR 19Sequence analysisAdd BLAST24
Repeati503 – 524LRR 20Sequence analysisAdd BLAST22
Repeati525 – 548LRR 21Sequence analysisAdd BLAST24
Repeati549 – 572LRR 22Sequence analysisAdd BLAST24
Repeati574 – 596LRR 23Sequence analysisAdd BLAST23
Repeati598 – 620LRR 24Sequence analysisAdd BLAST23
Repeati621 – 644LRR 25Sequence analysisAdd BLAST24
Repeati645 – 668LRR 26Sequence analysisAdd BLAST24
Repeati669 – 690LRR 27Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini760 – 1046Protein kinasePROSITE-ProRule annotationAdd BLAST287

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi173 – 174Small peptide recognitionCombined sources1 Publication2
Motifi195 – 198Small peptide recognitionCombined sources1 Publication4
Motifi218 – 223Small peptide recognitionCombined sources1 Publication6
Motifi246Small peptide recognitionCombined sources1 Publication1
Motifi268 – 270Small peptide recognitionCombined sources1 Publication3
Motifi316 – 319Small peptide recognitionCombined sources1 Publication4
Motifi338 – 340Small peptide recognitionCombined sources1 Publication3
Motifi386 – 390Small peptide recognitionCombined sources1 Publication5
Motifi412 – 415Small peptide recognitionCombined sources1 Publication4
Motifi434 – 438Small peptide recognitionCombined sources1 Publication5
Motifi458 – 460Small peptide recognitionCombined sources1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSU9, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_22_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
C0LGR3

Identification of Orthologs from Complete Genome Data

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OMAi
PNTPFFH

Database of Orthologous Groups

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OrthoDBi
826997at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
C0LGR3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR013210, LRR_N_plant-typ
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 3 hits
PF08263, LRRNT_2, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 8 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

C0LGR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPNIYRLSF FSSLLCFFFI PCFSLDQQGQ ALLSWKSQLN ISGDAFSSWH
60 70 80 90 100
VADTSPCNWV GVKCNRRGEV SEIQLKGMDL QGSLPVTSLR SLKSLTSLTL
110 120 130 140 150
SSLNLTGVIP KEIGDFTELE LLDLSDNSLS GDIPVEIFRL KKLKTLSLNT
160 170 180 190 200
NNLEGHIPME IGNLSGLVEL MLFDNKLSGE IPRSIGELKN LQVLRAGGNK
210 220 230 240 250
NLRGELPWEI GNCENLVMLG LAETSLSGKL PASIGNLKRV QTIAIYTSLL
260 270 280 290 300
SGPIPDEIGY CTELQNLYLY QNSISGSIPT TIGGLKKLQS LLLWQNNLVG
310 320 330 340 350
KIPTELGNCP ELWLIDFSEN LLTGTIPRSF GKLENLQELQ LSVNQISGTI
360 370 380 390 400
PEELTNCTKL THLEIDNNLI TGEIPSLMSN LRSLTMFFAW QNKLTGNIPQ
410 420 430 440 450
SLSQCRELQA IDLSYNSLSG SIPKEIFGLR NLTKLLLLSN DLSGFIPPDI
460 470 480 490 500
GNCTNLYRLR LNGNRLAGSI PSEIGNLKNL NFVDISENRL VGSIPPAISG
510 520 530 540 550
CESLEFLDLH TNSLSGSLLG TTLPKSLKFI DFSDNALSST LPPGIGLLTE
560 570 580 590 600
LTKLNLAKNR LSGEIPREIS TCRSLQLLNL GENDFSGEIP DELGQIPSLA
610 620 630 640 650
ISLNLSCNRF VGEIPSRFSD LKNLGVLDVS HNQLTGNLNV LTDLQNLVSL
660 670 680 690 700
NISYNDFSGD LPNTPFFRRL PLSDLASNRG LYISNAISTR PDPTTRNSSV
710 720 730 740 750
VRLTILILVV VTAVLVLMAV YTLVRARAAG KQLLGEEIDS WEVTLYQKLD
760 770 780 790 800
FSIDDIVKNL TSANVIGTGS SGVVYRITIP SGESLAVKKM WSKEESGAFN
810 820 830 840 850
SEIKTLGSIR HRNIVRLLGW CSNRNLKLLF YDYLPNGSLS SRLHGAGKGG
860 870 880 890 900
CVDWEARYDV VLGVAHALAY LHHDCLPTII HGDVKAMNVL LGPHFEPYLA
910 920 930 940 950
DFGLARTISG YPNTGIDLAK PTNRPPMAGS YGYMAPEHAS MQRITEKSDV
960 970 980 990 1000
YSYGVVLLEV LTGKHPLDPD LPGGAHLVKW VRDHLAEKKD PSRLLDPRLD
1010 1020 1030 1040 1050
GRTDSIMHEM LQTLAVAFLC VSNKANERPL MKDVVAMLTE IRHIDVGRSE
1060 1070 1080 1090
TEKIKAGGCG SKEPQQFMSN EKIINSHGSS NCSFAFSDDS V
Length:1,091
Mass (Da):119,529
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i061EFB0EDF281988
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL32011 differs from that shown. Reason: Frameshift.Curated
The sequence CAA18216 differs from that shown. Reason: Frameshift.Curated
The sequence CAA18216 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79509 differs from that shown. Reason: Frameshift.Curated
The sequence CAB79509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221L → P in AAL32011 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL022223 Genomic DNA Translation: CAA18216.1 Sequence problems.
AL161565 Genomic DNA Translation: CAB79509.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85216.1
AF436829 mRNA Translation: AAL32011.1 Frameshift.
FJ708754 mRNA Translation: ACN59348.1

Protein sequence database of the Protein Information Resource

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PIRi
T05050

NCBI Reference Sequences

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RefSeqi
NP_567748.5, NM_118787.6

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT4G26540.1; AT4G26540.1; AT4G26540

Database of genes from NCBI RefSeq genomes

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GeneIDi
828760

Gramene; a comparative resource for plants

More...
Gramenei
AT4G26540.1; AT4G26540.1; AT4G26540

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT4G26540

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022223 Genomic DNA Translation: CAA18216.1 Sequence problems.
AL161565 Genomic DNA Translation: CAB79509.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85216.1
AF436829 mRNA Translation: AAL32011.1 Frameshift.
FJ708754 mRNA Translation: ACN59348.1
PIRiT05050
RefSeqiNP_567748.5, NM_118787.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYXX-ray2.60B57-689[»]
5HZ0X-ray2.56B57-689[»]
5HZ1X-ray2.59B57-689[»]
5HZ3X-ray2.86B57-689[»]
SMRiC0LGR3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi14047, 44 interactors
IntActiC0LGR3, 44 interactors
STRINGi3702.AT4G26540.1

PTM databases

iPTMnetiC0LGR3

Proteomic databases

PaxDbiC0LGR3
PRIDEiC0LGR3
ProteomicsDBi236934

Genome annotation databases

EnsemblPlantsiAT4G26540.1; AT4G26540.1; AT4G26540
GeneIDi828760
GrameneiAT4G26540.1; AT4G26540.1; AT4G26540
KEGGiath:AT4G26540

Organism-specific databases

AraportiAT4G26540
TAIRilocus:2131518, AT4G26540

Phylogenomic databases

eggNOGiENOG502QSU9, Eukaryota
HOGENOMiCLU_000288_22_1_1
InParanoidiC0LGR3
OMAiPNTPFFH
OrthoDBi826997at2759
PhylomeDBiC0LGR3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:C0LGR3

Gene expression databases

ExpressionAtlasiC0LGR3, baseline and differential
GenevisibleiC0LGR3, AT

Family and domain databases

Gene3Di3.80.10.10, 7 hits
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR013210, LRR_N_plant-typ
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13855, LRR_8, 3 hits
PF08263, LRRNT_2, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 8 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGI3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0LGR3
Secondary accession number(s): O65580, Q8W556
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 5, 2009
Last modified: February 23, 2022
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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