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Protein

Probable LRR receptor-like serine/threonine-protein kinase At1g56140

Gene

At1g56140

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei721ATPPROSITE-ProRule annotation1
Active sitei817Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi699 – 707ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable LRR receptor-like serine/threonine-protein kinase At1g56140 (EC:2.7.11.1)
Gene namesi
Ordered Locus Names:At1g56140
ORF Names:F14G9.24, T6H22.8.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G56140
TAIRilocus:2011816 AT1G56140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 636ExtracellularSequence analysisAdd BLAST608
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 1033CytoplasmicSequence analysisAdd BLAST376

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000038753629 – 1033Probable LRR receptor-like serine/threonine-protein kinase At1g56140Add BLAST1005

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei682PhosphothreonineBy similarity1
Modified residuei766PhosphotyrosineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1
Modified residuei851PhosphothreonineBy similarity1
Modified residuei856PhosphothreonineBy similarity1
Modified residuei864PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiC0LGH3
PRIDEiC0LGH3

PTM databases

iPTMnetiC0LGH3

Expressioni

Gene expression databases

ExpressionAtlasiC0LGH3 baseline and differential
GenevisibleiC0LGH3 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G56140.1

Structurei

3D structure databases

ProteinModelPortaliC0LGH3
SMRiC0LGH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati97 – 121LRR 1Add BLAST25
Repeati122 – 145LRR 2Add BLAST24
Repeati147 – 169LRR 3Add BLAST23
Repeati170 – 193LRR 4Add BLAST24
Repeati195 – 217LRR 5Add BLAST23
Repeati241 – 264LRR 6Add BLAST24
Repeati265 – 288LRR 7Add BLAST24
Repeati289 – 313LRR 8Add BLAST25
Repeati314 – 337LRR 9Add BLAST24
Repeati339 – 361LRR 10Add BLAST23
Repeati363 – 382LRR 11Add BLAST20
Repeati383 – 406LRR 12Add BLAST24
Repeati422 – 445LRR 13Add BLAST24
Domaini693 – 951Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK0I Eukaryota
ENOG410XSG4 LUCA
HOGENOMiHOG000116550
InParanoidiC0LGH3
OMAiCIDSKSP
OrthoDBiEOG0936000Y
PhylomeDBiC0LGH3

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR021720 Malectin_dom
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF11721 Malectin, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: C0LGH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLWRYLCL LLTVWFLCNF GPVYVVRAQN RTGATTHPDE ALALNSIFAA
60 70 80 90 100
WRIRAPREWN ISGELCSGAA IDASVLDSNP AYNPLIKCDC SFENSTICRI
110 120 130 140 150
TNIKVYAMEV VGSIPQQLWT LEYLTNLNLG QNVLTGSLPP ALGNLTRMRW
160 170 180 190 200
MTFGINALSG PIPKEIGLLT DLRLLSISSN NFSGSIPDEI GRCTKLQQIY
210 220 230 240 250
IDSSGLSGGL PVSFANLVEL EQAWIADMEL TGQIPDFIGD WTKLTTLRIL
260 270 280 290 300
GTGLSGPIPA SFSNLTSLTE LRLGDISNGN SSLEFIKDMK SLSILVLRNN
310 320 330 340 350
NLTGTIPSNI GEYSSLRQLD LSFNKLHGTI PASLFNLRQL THLFLGNNTL
360 370 380 390 400
NGSLPTQKGQ SLSNVDVSYN DLSGSLPSWV SLPNLNLNLV ANNFTLEGLD
410 420 430 440 450
NRVLSGLNCL QKNFPCNRGK GIYSDFSINC GGPEIRSVTE AVFEREDEDL
460 470 480 490 500
GPASFVVSAG QRWAASSVGL FAGSSNNIYI STSQSQFVNT LDSELFQSAR
510 520 530 540 550
LSASSLRYYG LGLENGGYTV TLQFAEIQIL GSTSNTWRGL GRRRFDIYVQ
560 570 580 590 600
GRLVEKDFDV RRTAGDSTVR AVQREYKANV SQNHLEIHLF WAGKGTCCIP
610 620 630 640 650
IQGAYGPLIS AVGATPDFTP TVGNRPPSKG KSMTGTIVGV IVGVGLLSII
660 670 680 690 700
SGVVIFIIRK RRKRYTDDEE ILSMDVKPYT FTYSELKSAT QDFDPSNKLG
710 720 730 740 750
EGGFGPVYKG KLNDGREVAV KLLSVGSRQG KGQFVAEIVA ISAVQHRNLV
760 770 780 790 800
KLYGCCYEGE HRLLVYEYLP NGSLDQALFG EKTLHLDWST RYEICLGVAR
810 820 830 840 850
GLVYLHEEAR LRIVHRDVKA SNILLDSKLV PKVSDFGLAK LYDDKKTHIS
860 870 880 890 900
TRVAGTIGYL APEYAMRGHL TEKTDVYAFG VVALELVSGR PNSDENLEDE
910 920 930 940 950
KRYLLEWAWN LHEKGREVEL IDHQLTEFNM EEGKRMIGIA LLCTQTSHAL
960 970 980 990 1000
RPPMSRVVAM LSGDVEVSDV TSKPGYLTDW RFDDTTASSI SGFPLRNTQA
1010 1020 1030
SESFTSFVAP RSEISPRNND ARPMLGAQMN EGR
Note: Derived from EST data. No experimental confirmation available.
Length:1,033
Mass (Da):113,754
Last modified:November 3, 2009 - v2
Checksum:i2F091890AF9C8467
GO
Isoform 2 (identifier: C0LGH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-521: YYGLGLENGGYTVT → FYFQHLERFRKTTF
     522-1033: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):57,169
Checksum:i47BF9DDC4F815212
GO
Isoform 3 (identifier: C0LGH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-184: RLLSISSNNFSG → MTPQPPQSAAFH
     185-1033: Missing.

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):20,440
Checksum:i8D9BEDA441CAF2AD
GO
Isoform 4 (identifier: C0LGH3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-988: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,587
Checksum:iC3E1DDDCDC10FA67
GO

Sequence cautioni

The sequence AAF02840 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG50909 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ACN59258 differs from that shown. Reason: Frameshift at position 507.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275D → E in ACN59258 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03828596 – 988Missing in isoform 4. 1 PublicationAdd BLAST893
Alternative sequenceiVSP_038286173 – 184RLLSI…NNFSG → MTPQPPQSAAFH in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_038287185 – 1033Missing in isoform 3. 1 PublicationAdd BLAST849
Alternative sequenceiVSP_038288508 – 521YYGLG…GYTVT → FYFQHLERFRKTTF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_038289522 – 1033Missing in isoform 2. 1 PublicationAdd BLAST512

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009894 Genomic DNA Translation: AAF02840.1 Sequence problems.
AC069159 Genomic DNA Translation: AAG50909.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33348.1
BT011697 mRNA Translation: AAS49060.1
BT012256 mRNA Translation: AAS76743.1
AK228283 mRNA Translation: BAF00229.1
FJ708663 mRNA Translation: ACN59258.1 Frameshift.
PIRiG96602
RefSeqiNP_564709.2, NM_104492.4 [C0LGH3-1]
UniGeneiAt.42833

Genome annotation databases

EnsemblPlantsiAT1G56140.1; AT1G56140.1; AT1G56140 [C0LGH3-1]
GeneIDi842066
GrameneiAT1G56140.1; AT1G56140.1; AT1G56140 [C0LGH3-1]
KEGGiath:AT1G56140

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009894 Genomic DNA Translation: AAF02840.1 Sequence problems.
AC069159 Genomic DNA Translation: AAG50909.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33348.1
BT011697 mRNA Translation: AAS49060.1
BT012256 mRNA Translation: AAS76743.1
AK228283 mRNA Translation: BAF00229.1
FJ708663 mRNA Translation: ACN59258.1 Frameshift.
PIRiG96602
RefSeqiNP_564709.2, NM_104492.4 [C0LGH3-1]
UniGeneiAt.42833

3D structure databases

ProteinModelPortaliC0LGH3
SMRiC0LGH3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G56140.1

PTM databases

iPTMnetiC0LGH3

Proteomic databases

PaxDbiC0LGH3
PRIDEiC0LGH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G56140.1; AT1G56140.1; AT1G56140 [C0LGH3-1]
GeneIDi842066
GrameneiAT1G56140.1; AT1G56140.1; AT1G56140 [C0LGH3-1]
KEGGiath:AT1G56140

Organism-specific databases

AraportiAT1G56140
TAIRilocus:2011816 AT1G56140

Phylogenomic databases

eggNOGiENOG410IK0I Eukaryota
ENOG410XSG4 LUCA
HOGENOMiHOG000116550
InParanoidiC0LGH3
OMAiCIDSKSP
OrthoDBiEOG0936000Y
PhylomeDBiC0LGH3

Miscellaneous databases

PROiPR:C0LGH3

Gene expression databases

ExpressionAtlasiC0LGH3 baseline and differential
GenevisibleiC0LGH3 AT

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR021720 Malectin_dom
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF11721 Malectin, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiY5614_ARATH
AccessioniPrimary (citable) accession number: C0LGH3
Secondary accession number(s): Q0WRM0
, Q6NLS4, Q9C7J2, Q9SGU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 12, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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