UniProtKB - C0LGH2 (Y1561_ARATH)
Protein
Probable LRR receptor-like serine/threonine-protein kinase At1g56130
Gene
At1g56130
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 722 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 818 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 700 – 708 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- protein autophosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:At1g56130 ORF Names:F14G9.25, T6H22.8 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G56130 |
TAIRi | locus:2205250, AT1G56130 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysis; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 636 | ExtracellularSequence analysisAdd BLAST | 607 | |
Transmembranei | 637 – 657 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 658 – 1032 | CytoplasmicSequence analysisAdd BLAST | 375 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000387535 | 30 – 1032 | Probable LRR receptor-like serine/threonine-protein kinase At1g56130Add BLAST | 1003 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 302 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 348 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 352 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 394 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 580 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 633 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 683 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 767 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 822 | PhosphoserineBy similarity | 1 | |
Modified residuei | 851 | PhosphoserineBy similarity | 1 | |
Modified residuei | 852 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 857 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 865 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | C0LGH2 |
PRIDEi | C0LGH2 |
ProteomicsDBi | 242390 [C0LGH2-1] |
Expressioni
Gene expression databases
ExpressionAtlasi | C0LGH2, baseline and differential |
Genevisiblei | C0LGH2, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 27290, 20 interactors |
IntActi | C0LGH2, 20 interactors |
STRINGi | 3702.AT1G56130.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 101 – 122 | LRR 1Add BLAST | 22 | |
Repeati | 123 – 146 | LRR 2Add BLAST | 24 | |
Repeati | 148 – 170 | LRR 3Add BLAST | 23 | |
Repeati | 171 – 194 | LRR 4Add BLAST | 24 | |
Repeati | 196 – 217 | LRR 5Add BLAST | 22 | |
Repeati | 242 – 265 | LRR 6Add BLAST | 24 | |
Repeati | 290 – 314 | LRR 7Add BLAST | 25 | |
Repeati | 315 – 338 | LRR 8Add BLAST | 24 | |
Repeati | 340 – 360 | LRR 9Add BLAST | 21 | |
Repeati | 361 – 385 | LRR 10Add BLAST | 25 | |
Domaini | 694 – 968 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 275 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUW9, Eukaryota |
HOGENOMi | CLU_000288_114_1_1 |
InParanoidi | C0LGH2 |
OMAi | LEWAWYL |
OrthoDBi | 146580at2759 |
PhylomeDBi | C0LGH2 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR021720, Malectin_dom IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit PF11721, Malectin, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: C0LGH2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTRIRRSPCL LLLIIWFMCI AGSVQVVQSQ NQTGATTHPD EARALNSIFA
60 70 80 90 100
AWKIQAPREW NISGELCSGA AIDASVLDSN PAYNPLIKCD CSFQNSTICR
110 120 130 140 150
ITNIKVYAID VVGPIPPELW TLTYLTNLNL GQNVLTGSLP PAIGNLTRMQ
160 170 180 190 200
WMTFGINALS GPVPKEIGLL TDLRLLGISS NNFSGSIPDE IGRCTKLQQM
210 220 230 240 250
YIDSSGLSGR IPLSFANLVQ LEQAWIADLE VTDQIPDFIG DWTKLTTLRI
260 270 280 290 300
IGTGLSGPIP SSFSNLTSLT ELRLGDISSG SSSLDFIKDM KSLSVLVLRN
310 320 330 340 350
NNLTGTIPST IGEHSSLRQV DLSFNKLHGP IPASLFNLSQ LTHLFLGNNT
360 370 380 390 400
LNGSFPTQKT QSLRNVDVSY NDLSGSLPSW VSLPSLKLNL VANNFTLEGL
410 420 430 440 450
DNRVLPGLNC LQKNFPCNRG KGIYSDFSIN CGGPEKRSVT GALFEREDED
460 470 480 490 500
FGPASFFVSA GQRWAASSVG LFAGSSNNIY IATSQSQFVN TLDSELFQSA
510 520 530 540 550
RLSASSVRYY GLGLENGGYT VTLQFAEIQI LGSTSTTWKG LGRRRFDIYV
560 570 580 590 600
QGRLVEKDFD VRRTAGDSTV RAVQRVYKAN VSENHLEVHL FWAGKGTCCI
610 620 630 640 650
PIQGAYGPLI SAVSATPDFT PTVANKPPSK GKNRTGTIVG VIVGVGLLSI
660 670 680 690 700
LAGVVMFTIR KRRKRYTDDE ELLGMDVKPY IFTYSELKSA TQDFDPSNKL
710 720 730 740 750
GEGGFGPVYK GNLNDGRVVA VKLLSVGSRQ GKGQFVAEIV AISSVLHRNL
760 770 780 790 800
VKLYGCCFEG EHRMLVYEYL PNGSLDQALF GDKTLHLDWS TRYEICLGVA
810 820 830 840 850
RGLVYLHEEA SVRIVHRDVK ASNILLDSRL VPQISDFGLA KLYDDKKTHI
860 870 880 890 900
STRVAGTIGY LAPEYAMRGH LTEKTDVYAF GVVALELVSG RPNSDENLEE
910 920 930 940 950
EKKYLLEWAW NLHEKSRDIE LIDDKLTDFN MEEAKRMIGI ALLCTQTSHA
960 970 980 990 1000
LRPPMSRVVA MLSGDVEIGD VTSKPGYVSD WRFDDTTGSS LSGFQIKDTT
1010 1020 1030
GYSMSLVAPG SEISPRDSDF KPMLGSKINE GR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8ARB1 | A0A1P8ARB1_ARATH | Non-specific serine/threonine prote... | At1g56130, T6H22.8, T6H22_8 | 833 | Annotation score: | ||
A0A2H1ZEE2 | A0A2H1ZEE2_ARATH | Non-specific serine/threonine prote... | At1g56130, T6H22.8, T6H22_8 | 884 | Annotation score: |
Sequence cautioni
The sequence AAF02838 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG50912 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 151 | W → WI in AAG50912 (PubMed:11130712).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038283 | 509 – 522 | YYGLG…GYTVT → FYFYHLERFGTTTF in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_038284 | 523 – 1032 | Missing in isoform 2. 1 PublicationAdd BLAST | 510 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009894 Genomic DNA Translation: AAF02838.1 Sequence problems. AC069159 Genomic DNA Translation: AAG50912.1 Sequence problems. CP002684 Genomic DNA Translation: ANM59201.1 FJ708662 mRNA Translation: ACN59257.1 |
PIRi | F96602 |
RefSeqi | NP_176009.1, NM_104491.2 [C0LGH2-1] |
Genome annotation databases
EnsemblPlantsi | AT1G56130.2; AT1G56130.2; AT1G56130 [C0LGH2-1] |
GeneIDi | 842065 |
Gramenei | AT1G56130.2; AT1G56130.2; AT1G56130 [C0LGH2-1] |
KEGGi | ath:AT1G56130 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC009894 Genomic DNA Translation: AAF02838.1 Sequence problems. AC069159 Genomic DNA Translation: AAG50912.1 Sequence problems. CP002684 Genomic DNA Translation: ANM59201.1 FJ708662 mRNA Translation: ACN59257.1 |
PIRi | F96602 |
RefSeqi | NP_176009.1, NM_104491.2 [C0LGH2-1] |
3D structure databases
SMRi | C0LGH2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 27290, 20 interactors |
IntActi | C0LGH2, 20 interactors |
STRINGi | 3702.AT1G56130.1 |
Proteomic databases
PaxDbi | C0LGH2 |
PRIDEi | C0LGH2 |
ProteomicsDBi | 242390 [C0LGH2-1] |
Genome annotation databases
EnsemblPlantsi | AT1G56130.2; AT1G56130.2; AT1G56130 [C0LGH2-1] |
GeneIDi | 842065 |
Gramenei | AT1G56130.2; AT1G56130.2; AT1G56130 [C0LGH2-1] |
KEGGi | ath:AT1G56130 |
Organism-specific databases
Araporti | AT1G56130 |
TAIRi | locus:2205250, AT1G56130 |
Phylogenomic databases
eggNOGi | ENOG502QUW9, Eukaryota |
HOGENOMi | CLU_000288_114_1_1 |
InParanoidi | C0LGH2 |
OMAi | LEWAWYL |
OrthoDBi | 146580at2759 |
PhylomeDBi | C0LGH2 |
Miscellaneous databases
PROi | PR:C0LGH2 |
Gene expression databases
ExpressionAtlasi | C0LGH2, baseline and differential |
Genevisiblei | C0LGH2, AT |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR021720, Malectin_dom IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit PF11721, Malectin, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1561_ARATH | |
Accessioni | C0LGH2Primary (citable) accession number: C0LGH2 Secondary accession number(s): Q9C7J1, Q9SGT9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families