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Protein

Phosphoglycerate kinase

Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Glyceraldehyde-3-phosphate dehydrogenase (D915_13480)
  2. Phosphoglycerate kinase (D915_03905), Phosphoglycerate kinase, Phosphoglycerate kinase (D915_03906), Phosphoglycerate kinase
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (D915_02241), Pyruvate kinase (D915_13877)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31SubstrateUniRule annotation1
Binding sitei114SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Binding sitei211ATPUniRule annotation1
Binding sitei304ATP; via carbonyl oxygenUniRule annotation1
Binding sitei335ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi364 – 367ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
OrganismiFasciola hepatica (Liver fluke)Imported
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 18Substrate bindingUniRule annotation3
Regioni55 – 58Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Fragment.

C0L7L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
IANVDLKGKR VLIRVDFNVP MKDGKITNNQ RIVAALPTIK YALEKGAKSV
60 70 80 90 100
VLMSHLGRPD GNKVDKYSLK PVAEEVSKLL GKAVQFLPDC VGDATLQACS
110 120 130 140 150
NPAPGSVFLL ENLRFHVEEE GKGVGPNGEK VKADPAKVKA FSESLTKLGD
160 170 180 190 200
VYVNDAFGTA HRAHASMVGC NLPQKACGFL MDKELTYFAK ALENPARPFL
210 220 230 240 250
AIIGGAKVSD KIQLIKNMLD KVNELIITGG MAFTFLKKLH NMKIGKSLFD
260 270 280 290 300
EPGAAIVDEV MALAKQKKVE IHLPVDFVTG SKFGDDATVG SATVESGIPD
310 320 330 340 350
DYMGLDCGPK TMEKFRAVIL RAKTIVWNGP MGVFEMEKFA GGTKAAMDAV
360 370 380 390 400
VEATKNGATT IIGGGDTATC CAKWKTEDKV SHVSTGGGAS LELLEGKELP

GVVALTNA
Length:408
Mass (Da):43,421
Last modified:May 5, 2009 - v1
Checksum:i9A0C341856AC4C0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ666097 mRNA Translation: ACN50260.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ666097 mRNA Translation: ACN50260.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00185

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC0L7L5_FASHE
AccessioniPrimary (citable) accession number: C0L7L5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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