UniProtKB - C0HLK1 (CA1B_CONBR)
Protein
Alpha-conotoxin BruIB
Gene
N/A
Organism
Conus brunneus (Wood's brown cone)
Status
Functioni
Acts as an inhibitor of nicotinic acetylcholine receptors (nAChR) (PubMed:25466886). Specifically inhibits the alpha-7 nAChRs of D.melanogaster, and seems to have no inhibitory effect on vertebrate nAChR subtypes (PubMed:25466886).1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-conotoxin BruIB1 Publication |
Organismi | Conus brunneus (Wood's brown cone) |
Taxonomic identifieri | 101289 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Stephanoconus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- host cell postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000447213 | 1 – 13 | Alpha-conotoxin BruIB1 PublicationAdd BLAST | 13 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 9 | By similarity | ||
Disulfide bondi | 4 ↔ 13 | By similarity | ||
Modified residuei | 7 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 13 | Cysteine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bond, HydroxylationExpressioni
Tissue specificityi
Expressed by the venom duct (at protein level).1 Publication
Family & Domainsi
Domaini
The cysteine framework is I (CC-C-C). Alpha4/3 pattern.Curated
Sequence similaritiesi
Belongs to the conotoxin A superfamily.Curated
i Sequence
Sequence statusi: Complete.
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CA1B_CONBR | |
Accessioni | C0HLK1Primary (citable) accession number: C0HLK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 8, 2019 |
Last sequence update: | May 8, 2019 | |
Last modified: | July 31, 2019 | |
This is version 3 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families