UniProtKB - C0HKQ6 (XAC2_XYLAI)
Protein
Antimicrobial peptide Xac-2
Gene
N/A
Organism
Xylocopa appendiculata circumvolans (Japanese carpenter bee)
Status
Functioni
Antimicrobial and mast cell degranulating peptide which probably acts by forming pores in membranes. Active against Gram-negative bacterium E.coli NBRC 14237 (MIC=3.12 µM), against Gram-positive bacteria S.aureus NBRC 12732 (MIC=3.12 µM) and M.luteus NBRC 12708 (MIC=6.25 µM) as well as against yeast S.cerevisiae NBRC 10217 (MIC=25 µM). Has hemolytic activity (at 100 µM).1 Publication
GO - Biological processi
- defense response to fungus Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- hemolysis in other organism Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Fungicide |
Biological process | Cytolysis, Hemolysis |
Names & Taxonomyi
Protein namesi | Recommended name: Antimicrobial peptide Xac-21 PublicationAlternative name(s): Xylopinin1 Publication |
Organismi | Xylocopa appendiculata circumvolans (Japanese carpenter bee)1 Publication |
Taxonomic identifieri | 135722 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Hymenoptera › Apocrita › Aculeata › Apoidea › Apidae › Xylocopa › Alloxylocopa › |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Other locations
- Target cell membrane 1 Publication
Note: Assumes an amphipathic alpha-helical conformation in a lipid environment.1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Other locations
- membrane Source: UniProtKB-KW
- other organism cell membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, Secreted, Target cell membrane, Target membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000441218 | 1 – 17 | Antimicrobial peptide Xac-22 PublicationsAdd BLAST | 17 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | Proline amide2 Publications | 1 |
Keywords - PTMi
AmidationExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
ProtoNeti | Search... |
Entry informationi
Entry namei | XAC2_XYLAI | |
Accessioni | C0HKQ6Primary (citable) accession number: C0HKQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2017 |
Last sequence update: | August 30, 2017 | |
Last modified: | November 22, 2017 | |
This is version 3 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |