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Protein

Microfibrillar-associated protein 1A

Gene

Mfap1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as a component of the spliceosome.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 1AImported
Alternative name(s):
Spliceosome B complex protein MFAP1ACurated
Gene namesi
Name:Mfap1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914782 Mfap1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000964592 – 439Microfibrillar-associated protein 1AAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei52PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei94PhosphoserineBy similarity1
Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphoserineBy similarity1
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei267PhosphothreonineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei361PhosphoserineBy similarity1
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei432PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiC0HKD8

PTM databases

iPTMnetiC0HKD8
PhosphoSitePlusiC0HKD8

Expressioni

Gene expression databases

ExpressionAtlasiC0HKD8 baseline and differential

Interactioni

Subunit structurei

Component of the spliceosome B complex. Interacts with PRPF38A (via N-terminal interaction domain).By similarity

Structurei

3D structure databases

SMRiC0HKD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 318Glu-richPROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the MFAP1 family.Curated

Phylogenomic databases

KOiK13110
OMAiDSAWAQE

Family and domain databases

InterProiView protein in InterPro
IPR033194 MFAP1
IPR009730 MFAP1_C
PANTHERiPTHR15327:SF0 PTHR15327:SF0, 1 hit
PfamiView protein in Pfam
PF06991 MFAP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C0HKD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVPSALMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM
60 70 80 90 100
ESSDEEDEEF QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER
110 120 130 140 150
LARHRKIVEP EVVGESDSEV EGDAWRLERE DSSEEEEEEI DDEEIERRRG
160 170 180 190 200
MMRQRAQERK NEEMEVMEVE DEGRSGEESE SESEYEEYTD SEDEMEPRLK
210 220 230 240 250
PVFIRKKDRV TVQEREAEAL KQKELEQEAK RMAEERRKYT LKIVEEETKK
260 270 280 290 300
ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRE REDREALEKE
310 320 330 340 350
KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD
360 370 380 390 400
EDEEVYKRDF SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT
410 420 430
SFDSAWGQES AQNTKFFKQK AAGVRDVFER PSAKKRKTT
Length:439
Mass (Da):51,954
Last modified:April 12, 2017 - v1
Checksum:i5B57B1F1C42421E8
GO

Sequence cautioni

The sequence BAC27936 differs from that shown. Reason: Erroneous termination at position 440. Translated as stop.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012688 mRNA Translation: BAB28412.3
AK014483 mRNA Translation: BAB29385.1
AK032586 mRNA Translation: BAC27936.1 Different termination.
AK050561 mRNA Translation: BAC34325.1
AK077604 mRNA Translation: BAC36894.1
AK088766 mRNA Translation: BAC40557.1
AK161000 mRNA Translation: BAE36142.1
CCDSiCCDS16648.1
RefSeqiNP_001075444.1, NM_001081975.3
NP_080496.1, NM_026220.4
UniGeneiMm.270393
Mm.440764

Genome annotation databases

EnsembliENSMUST00000056732; ENSMUSP00000049548; ENSMUSG00000048222
ENSMUST00000089926; ENSMUSP00000087372; ENSMUSG00000068479
GeneIDi100034361
67532
KEGGimmu:100034361
mmu:67532

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012688 mRNA Translation: BAB28412.3
AK014483 mRNA Translation: BAB29385.1
AK032586 mRNA Translation: BAC27936.1 Different termination.
AK050561 mRNA Translation: BAC34325.1
AK077604 mRNA Translation: BAC36894.1
AK088766 mRNA Translation: BAC40557.1
AK161000 mRNA Translation: BAE36142.1
CCDSiCCDS16648.1
RefSeqiNP_001075444.1, NM_001081975.3
NP_080496.1, NM_026220.4
UniGeneiMm.270393
Mm.440764

3D structure databases

SMRiC0HKD8
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiC0HKD8
PhosphoSitePlusiC0HKD8

Proteomic databases

PRIDEiC0HKD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056732; ENSMUSP00000049548; ENSMUSG00000048222
ENSMUST00000089926; ENSMUSP00000087372; ENSMUSG00000068479
GeneIDi100034361
67532
KEGGimmu:100034361
mmu:67532

Organism-specific databases

CTDi100034361
67532
MGIiMGI:1914782 Mfap1a

Phylogenomic databases

KOiK13110
OMAiDSAWAQE

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

PROiPR:C0HKD8
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiC0HKD8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033194 MFAP1
IPR009730 MFAP1_C
PANTHERiPTHR15327:SF0 PTHR15327:SF0, 1 hit
PfamiView protein in Pfam
PF06991 MFAP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFA1A_MOUSE
AccessioniPrimary (citable) accession number: C0HKD8
Secondary accession number(s): Q3TU29
, Q8CCL1, Q9CQU1, Q9CSJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: April 12, 2017
Last modified: November 7, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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