UniProtKB - C0HKA6 (TRYGT_DROER)
Protein
Trypsin gamma
Gene
gammaTry
Organism
Drosophila erecta (Fruit fly)
Status
Functioni
Catalytic activityi
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. EC:3.4.21.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 71 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 116 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Sitei | 204 | Required for specificityCurated | 1 | |
Active sitei | 210 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gammaTryBy similarity |
Organismi | Drosophila erecta (Fruit fly) |
Taxonomic identifieri | 7220 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Subcellular locationi
Extracellular region or secreted
- extracellular space By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | CuratedAdd BLAST | 22 | |
PropeptideiPRO_0000438903 | 23 – 30 | Activation peptide | 8 | |
ChainiPRO_0000438904 | 31 – 253 | Trypsin gammaAdd BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 72 | PROSITE-ProRule annotation | ||
Disulfide bondi | 180 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 206 ↔ 230 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 253 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 223 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
C0HKA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKFVILLSA VACALGGTIP EGLLPQLDGR IVGGTATTIS SFPWQISLQR
60 70 80 90 100
SGSHSCGGSI YTDRVIVTAA HCLQSVSTSS LQIRAGSSYW NSGGVTVKVS
110 120 130 140 150
SFKNHEGYSA RTMVNDIAVI RLSSSLSFSS TIKSISLASS NPPNGAAASV
160 170 180 190 200
SGWGTQSSGS NSIPSQLQYV NVNIVSQSRC ASSTYGYGSD IRDTMICAAA
210 220 230 240 250
SGKDACQGDS GGPLVSGGVL VGVVSWGQGC AYSNYPGVYA SVADLRAWVV
RNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40653 Genomic DNA Translation: AAA83242.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U40653 Genomic DNA Translation: AAA83242.1 |
3D structure databases
SMRi | C0HKA6 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRYGT_DROER | |
Accessioni | C0HKA6Primary (citable) accession number: C0HKA6 Secondary accession number(s): P54626 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2017 |
Last sequence update: | February 15, 2017 | |
Last modified: | December 2, 2020 | |
This is version 8 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Documents
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families