UniProtKB - C0HK73 (VKT2_HETMG)
Protein
Kunitz-type serine protease inhibitor HMGS1
Gene
N/A
Organism
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
Status
Functioni
Serine protease inhibitor.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 14 – 15 | Reactive bond for trypsinBy similarity | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Names & Taxonomyi
Protein namesi | Recommended name: Kunitz-type serine protease inhibitor HMGS11 Publication |
Organismi | Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)1 Publication |
Taxonomic identifieri | 38281 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Stichodactylidae › Heteractis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Nematocyst Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- nematocyst Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nematocyst, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000443114 | 1 – 56 | Kunitz-type serine protease inhibitor HMGS11 PublicationAdd BLAST | 56 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 4 ↔ 54 | PROSITE-ProRule annotation | ||
Disulfide bondi | 13 ↔ 37 | PROSITE-ProRule annotation | ||
Disulfide bondi | 29 ↔ 50 | PROSITE-ProRule annotation |
Post-translational modificationi
Contains three disulfide bonds.1 Publication
Keywords - PTMi
Disulfide bondFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 54 | BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.Curated
Family and domain databases
CDDi | cd00109 KU, 1 hit |
Gene3Di | 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS |
Pfami | View protein in Pfam PF00014 Kunitz_BPTI, 1 hit |
PRINTSi | PR00759 BASICPTASE |
SMARTi | View protein in SMART SM00131 KU, 1 hit |
SUPFAMi | SSF57362 SSF57362, 1 hit |
PROSITEi | View protein in PROSITE PS00280 BPTI_KUNITZ_1, 1 hit PS50279 BPTI_KUNITZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
C0HK73-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GSICLEPKVV GPCKAGIRRF YFDSETGKCT LFLYGGCKGN GNNFETLHAC
RAICRA
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | C0HK73 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
CDDi | cd00109 KU, 1 hit |
Gene3Di | 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR020901 Prtase_inh_Kunz-CS |
Pfami | View protein in Pfam PF00014 Kunitz_BPTI, 1 hit |
PRINTSi | PR00759 BASICPTASE |
SMARTi | View protein in SMART SM00131 KU, 1 hit |
SUPFAMi | SSF57362 SSF57362, 1 hit |
PROSITEi | View protein in PROSITE PS00280 BPTI_KUNITZ_1, 1 hit PS50279 BPTI_KUNITZ_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | VKT2_HETMG | |
Accessioni | C0HK73Primary (citable) accession number: C0HK73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2018 |
Last sequence update: | February 28, 2018 | |
Last modified: | October 10, 2018 | |
This is version 4 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families