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Entry version 12 (31 Jul 2019)
Sequence version 1 (09 Dec 2015)
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Lablab purpureus (Hyacinth bean) (Dolichos lablab)
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Liberates mannose from p-nitrophenyl-alpha-D-mannoside.1 Publication

<p>This subsection of the <a href="">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

<p>This subsection of the <a href="">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by swainsonine but not by 1-desoxymannojirimycin.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.48 mM for p-nitrophenyl-alpha-D-mannopyranoside1 Publication

    pH dependencei

    Optimum pH is 5.1 Publication

    Temperature dependencei

    Optimum temperature is 65 degrees Celsius. Activity decreases sharply above 70 degrees Celsius.1 Publication


    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei17NucleophileBy similarity1

    <p>The <a href="">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosidase, Hydrolase
    LigandMetal-binding, Zinc

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Alpha-mannosidase1 Publication (EC: Publication)
    <p>This subsection of the <a href="">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLablab purpureus (Hyacinth bean) (Dolichos lablab)1 Publication
    <p>This subsection of the <a href="">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri35936 [NCBI]
    <p>This subsection of the <a href="">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeindigoferoid/millettioid cladePhaseoleaeLablab

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004350021 – 290Alpha-mannosidaseAdd BLAST290

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1

    Keywords - PTMi


    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context


    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei


    1 Publication

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models


    Database of comparative protein structure models


    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.1 Publication

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    1.20.1270.50, 2 hits

    Integrated resource of protein families, domains and functional sites

    View protein in InterPro
    IPR011013 Gal_mutarotase_sf_dom
    IPR011330 Glyco_hydro/deAcase_b/a-brl
    IPR037094 Glyco_hydro_38_cen_sf
    IPR028995 Glyco_hydro_57/38_cen_sf

    Superfamily database of structural and functional annotation

    SSF74650 SSF74650, 1 hit
    SSF88688 SSF88688, 1 hit
    SSF88713 SSF88713, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="">length</a> and <a href="">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="">Sequence</a> section indicates if the <a href="">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragments.

    C0HJW7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    60 70 80 90 100
    110 120 130 140 150
    160 170 180 190 200
    210 220 230 240 250
    260 270 280 290
    Mass (Da):32,157
    Last modified:December 9, 2015 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B58C33A8666E361

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequences’ section is used to describe region(s) of a sequence for which the authors are unsure about the sequence assignment.<p><a href='/help/unsure' target='_top'>More...</a></p>Sequence uncertaintyi1L or I1 Publication1
    Sequence uncertaintyi6Q or K1 Publication1
    Sequence uncertaintyi7L or I1 Publication1
    Sequence uncertaintyi10I or L1 Publication1
    <p>This subsection of the ‘Sequence’ section is used to indicate that two residues in a sequence are not consecutive and that there is an undetermined number of unsequenced residues between them.<p><a href='/help/non_cons' target='_top'>More...</a></p>Non-adjacent residuesi14 – 151 Publication2
    Sequence uncertaintyi15Q or K1 Publication1
    Sequence uncertaintyi16I or L1 Publication1
    Sequence uncertaintyi25Q or K1 Publication1
    Non-adjacent residuesi27 – 281 Publication2
    Sequence uncertaintyi35L or I1 Publication1
    Sequence uncertaintyi38Q or K1 Publication1
    Sequence uncertaintyi43L or I1 Publication1
    Sequence uncertaintyi49Q or K1 Publication1
    Sequence uncertaintyi60L or I1 Publication1
    Sequence uncertaintyi62Q or K1 Publication1
    Sequence uncertaintyi65I or L1 Publication1
    Non-adjacent residuesi67 – 681 Publication2
    Sequence uncertaintyi71L or I1 Publication1
    Sequence uncertaintyi77I or L1 Publication1
    Sequence uncertaintyi82K or Q1 Publication1
    Sequence uncertaintyi91L or I1 Publication1
    Sequence uncertaintyi92K or Q1 Publication1
    Non-adjacent residuesi102 – 1031 Publication2
    Sequence uncertaintyi112L or I1 Publication1
    Sequence uncertaintyi116L or I1 Publication1
    Sequence uncertaintyi118I or L1 Publication1
    Sequence uncertaintyi120Q or K1 Publication1
    Non-adjacent residuesi130 – 1311 Publication2
    Sequence uncertaintyi130K or Q1 Publication1
    Sequence uncertaintyi131L or I1 Publication1
    Sequence uncertaintyi133I or L1 Publication1
    Sequence uncertaintyi136Q or K1 Publication1
    Sequence uncertaintyi141L or I1 Publication1
    Sequence uncertaintyi146L or I1 Publication1
    Non-adjacent residuesi148 – 1491 Publication2
    Sequence uncertaintyi150Q or K1 Publication1
    Sequence uncertaintyi155L or I1 Publication1
    Sequence uncertaintyi157I or L1 Publication1
    Sequence uncertaintyi160Q or K1 Publication1
    Sequence uncertaintyi161L or I1 Publication1
    Sequence uncertaintyi162L or I1 Publication1
    Sequence uncertaintyi164Q or K1 Publication1
    Sequence uncertaintyi165Q or K1 Publication1
    Non-adjacent residuesi166 – 1671 Publication2
    Sequence uncertaintyi166K or Q1 Publication1
    Sequence uncertaintyi172L or I1 Publication1
    Sequence uncertaintyi180L or I1 Publication1
    Non-adjacent residuesi183 – 1841 Publication2
    Sequence uncertaintyi183K or Q1 Publication1
    Non-adjacent residuesi188 – 1891 Publication2
    Sequence uncertaintyi189Q or K1 Publication1
    Sequence uncertaintyi195L or I1 Publication1
    Non-adjacent residuesi202 – 2031 Publication2
    Sequence uncertaintyi207K or Q1 Publication1
    Sequence uncertaintyi208L or I1 Publication1
    Sequence uncertaintyi211L or I1 Publication1
    Sequence uncertaintyi216L or I1 Publication1
    Sequence uncertaintyi221Q or K1 Publication1
    Sequence uncertaintyi222Q or K1 Publication1
    Sequence uncertaintyi223I or L1 Publication1
    Sequence uncertaintyi227I or L1 Publication1
    Sequence uncertaintyi229Q or K1 Publication1
    Sequence uncertaintyi230I or L1 Publication1
    Non-adjacent residuesi232 – 2331 Publication2
    Sequence uncertaintyi235L or I1 Publication1
    Sequence uncertaintyi240L or I1 Publication1
    Sequence uncertaintyi245L or I1 Publication1
    Sequence uncertaintyi246Q or K1 Publication1
    Sequence uncertaintyi249Q or K1 Publication1
    Sequence uncertaintyi250I or L1 Publication1
    Non-adjacent residuesi252 – 2531 Publication2
    Sequence uncertaintyi252L or I1 Publication1
    Sequence uncertaintyi256I or L1 Publication1
    Sequence uncertaintyi259L or I1 Publication1
    Sequence uncertaintyi264K or Q1 Publication1
    Sequence uncertaintyi271Q or K1 Publication1
    Sequence uncertaintyi273I or L1 Publication1
    Sequence uncertaintyi277L or I1 Publication1
    Sequence uncertaintyi278L or I1 Publication1
    Sequence uncertaintyi279L or I1 Publication1
    Sequence uncertaintyi284Q or K1 Publication1
    Sequence uncertaintyi287Q or K1 Publication1

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    3D structure databases


    PTM databases


    Family and domain databases

    Gene3Di1.20.1270.50, 2 hits
    InterProiView protein in InterPro
    IPR011013 Gal_mutarotase_sf_dom
    IPR011330 Glyco_hydro/deAcase_b/a-brl
    IPR037094 Glyco_hydro_38_cen_sf
    IPR028995 Glyco_hydro_57/38_cen_sf
    SUPFAMiSSF74650 SSF74650, 1 hit
    SSF88688 SSF88688, 1 hit
    SSF88713 SSF88713, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins


    MobiDB: a database of protein disorder and mobility annotations


    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMANA_LABPU
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0HJW7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
    Last sequence update: December 9, 2015
    Last modified: July 31, 2019
    This is version 12 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing


    1. SIMILARITY comments
      Index of protein domains and families
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    UniProt is an ELIXIR core data resource
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