UniProtKB - C0HJN0 (KAX6V_HETLA)
Protein
Potassium channel toxin alpha-KTx 6 hetlaxin
Gene
N/A
Organism
Heterometrus laoticus (Thai giant scorpion)
Status
Functioni
Binds to voltage-gated potassium channels Kv1.3/KCNA3 (IC50=0.48 µM) and Kv1.1/KCNA1 (IC50=6.7 µM) and inhibits channel activity.2 Publications
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 6 hetlaxin |
Organismi | Heterometrus laoticus (Thai giant scorpion) |
Taxonomic identifieri | 217256 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000430775 | 1 – 34 | Potassium channel toxin alpha-KTx 6 hetlaxin1 PublicationAdd BLAST | 34 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 24 | By similarity | ||
Disulfide bondi | 9 ↔ ? | By similarity | ||
Disulfide bondi | 13 ↔ 19 | By similarity | ||
Disulfide bondi | 31 ↔ 34 | By similarity | ||
Modified residuei | 34 | Cysteine amide1 Publication | 1 |
Post-translational modificationi
Contains 4 disulfide bonds.2 Publications
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.2 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 06 subfamily.Sequence analysis
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX6V_HETLA | |
Accessioni | C0HJN0Primary (citable) accession number: C0HJN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | November 22, 2017 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families