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UniProtKB - C0H531 (C0H531_PLAF7)

Entry version 62 (31 Jul 2019)
Sequence version 1 (05 May 2009)
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Protein

DNA primase large subunit

Gene

PF3D7_0910900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi362Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi438Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi456Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi496Iron-sulfur (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotationImported, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-PFA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-174430 Telomere C-strand synthesis initiation
R-PFA-68952 DNA replication initiation
R-PFA-68962 Activation of the pre-replicative complex
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0910900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		PlasmoDB:PF3D7_0910900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		C0H531

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		C0H531

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000282854

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		C0H531

KEGG Orthology (KO)

More...KOi		K02685

Identification of Orthologs from Complete Genome Data

More...OMAi		DCHGCPY

Database for complete collections of gene phylogenies

More...PhylomeDBi		C0H531

Family and domain databases

Conserved Domains Database

More...CDDi		cd07322 PriL_PriS_Eukaryotic, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016558 DNA_primase_lsu_euk
IPR007238 DNA_primase_lsu_euk/arc

The PANTHER Classification System

More...PANTHERi		PTHR10537 PTHR10537, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04104 DNA_primase_lrg, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF009449 DNA_primase_large_subunit, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C0H531-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIRKKSLSG IPHEKGKLNE KKLQNITIKN YEITNDESKK AFFDYYSCIY 
        60         70         80         90        100
PFNMPISLYK YPPIFGYCSL SDFQEIGAKR LALLQFLDTC TISGDDEKDQ 
       110        120        130        140        150
YTNLRKTDKN YSLNNTTDNK NKIIRQKIYE YKFGIQSMKD YNKEEMENII 
       160        170        180        190        200
MTDLLSHYIL RIAFSKDKEK QQWFLKQELK LFTFRLNELK NINVLNSQNI 
       210        220        230        240        250
SESERGLVHL LKRENIHYES ITKPSISYGN KNDEWEKYTE FIPNKDTIQK 
       260        270        280        290        300
LFKVPFYPDA YFLVRDHKVV VEKGVAYVPD IYLDIILTVQ FKLNIKESFK 
       310        320        330        340        350
YLDHNEKMLL KIQNDPRIST FLSSLPKAYV AKDFRQNYEH TQDTRLSPQN 
       360        370        380        390        400
LYSVYKQSFP PCMRRIFVNY IKDKHLKHWG RQQLWLFLKG AGMTLDENIQ 
       410        420        430        440        450
TNRSIWLQPD KFDKEHRYNI RYMYGKEGKK TDFSPYNCSK IINNFPVPSS 
       460        470        480        490        500
NDIHGCPFKN FDESHLKSLL YFFGLSDEQI KSIMPLKRNN EYQMACVKFF 
       510        520        530 
METHPGSVGD GVGNHPNSYY VESRKYYKSK TSGSEKIIN
Length:539
Mass (Da):63,945
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i140D694277B33568
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAX64208.1

NCBI Reference Sequences

More...RefSeqi		XP_002808927.1, XM_002808881.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAX64208; CAX64208; PF3D7_0910900

GeneDB pathogen genome database from Sanger Institute

More...GeneDBi		PF3D7_0910900.1:pep

Database of genes from NCBI RefSeq genomes

More...GeneIDi		813386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pfa:PF3D7_0910900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844508 Genomic DNA Translation: CAX64208.1
RefSeqiXP_002808927.1, XM_002808881.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

PTM databases

SwissPalmiC0H531

Proteomic databases

PRIDEiC0H531

Genome annotation databases

EnsemblProtistsiCAX64208; CAX64208; PF3D7_0910900
GeneDBiPF3D7_0910900.1:pep
GeneIDi813386
KEGGipfa:PF3D7_0910900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0910900

Phylogenomic databases

HOGENOMiHOG000282854
InParanoidiC0H531
KOiK02685
OMAiDCHGCPY
PhylomeDBiC0H531

Enzyme and pathway databases

ReactomeiR-PFA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-174430 Telomere C-strand synthesis initiation
R-PFA-68952 DNA replication initiation
R-PFA-68962 Activation of the pre-replicative complex
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Family and domain databases

CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
InterProiView protein in InterPro
IPR016558 DNA_primase_lsu_euk
IPR007238 DNA_primase_lsu_euk/arc
PANTHERiPTHR10537 PTHR10537, 1 hit
PfamiView protein in Pfam
PF04104 DNA_primase_lrg, 1 hit
PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC0H531_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0H531
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: July 31, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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