UniProtKB - C0H531 (C0H531_PLAF7)
Protein
DNA primase large subunit
Gene
PF3D7_0910900
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation
Cofactori
[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 362 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 | |
Metal bindingi | 438 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 | |
Metal bindingi | 456 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 | |
Metal bindingi | 496 | Iron-sulfur (4Fe-4S)UniRule annotation | 1 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-UniRule
- DNA binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
- nucleotidyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- DNA replication, synthesis of RNA primer Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, NucleotidyltransferaseImported, Transferase |
Biological process | DNA replicationUniRule annotationARBA annotation |
Ligand | 4Fe-4SUniRule annotationARBA annotation, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
Reactomei | R-PFA-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-PFA-68952, DNA replication initiation R-PFA-68962, Activation of the pre-replicative complex R-PFA-69091, Polymerase switching R-PFA-69166, Removal of the Flap Intermediate R-PFA-69183, Processive synthesis on the lagging strand |
Names & Taxonomyi
Protein namesi | Recommended name: DNA primase large subunitUniRule annotation |
Gene namesi | ORF Names:PF3D7_0910900Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0910900 |
Subcellular locationi
GO - Cellular componenti
- alpha DNA polymerase:primase complex Source: GO_Central
Keywords - Cellular componenti
PrimosomeUniRule annotationARBA annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_026253_2_0_1 |
InParanoidi | C0H531 |
OMAi | DCHGCPY |
PhylomeDBi | C0H531 |
Family and domain databases
CDDi | cd07322, PriL_PriS_Eukaryotic, 1 hit |
InterProi | View protein in InterPro IPR016558, DNA_primase_lsu_euk IPR007238, DNA_primase_lsu_euk/arc |
PANTHERi | PTHR10537, PTHR10537, 1 hit |
Pfami | View protein in Pfam PF04104, DNA_primase_lrg, 1 hit |
PIRSFi | PIRSF009449, DNA_primase_large_subunit, 1 hit |
i Sequence
Sequence statusi: Complete.
C0H531-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIIRKKSLSG IPHEKGKLNE KKLQNITIKN YEITNDESKK AFFDYYSCIY
60 70 80 90 100
PFNMPISLYK YPPIFGYCSL SDFQEIGAKR LALLQFLDTC TISGDDEKDQ
110 120 130 140 150
YTNLRKTDKN YSLNNTTDNK NKIIRQKIYE YKFGIQSMKD YNKEEMENII
160 170 180 190 200
MTDLLSHYIL RIAFSKDKEK QQWFLKQELK LFTFRLNELK NINVLNSQNI
210 220 230 240 250
SESERGLVHL LKRENIHYES ITKPSISYGN KNDEWEKYTE FIPNKDTIQK
260 270 280 290 300
LFKVPFYPDA YFLVRDHKVV VEKGVAYVPD IYLDIILTVQ FKLNIKESFK
310 320 330 340 350
YLDHNEKMLL KIQNDPRIST FLSSLPKAYV AKDFRQNYEH TQDTRLSPQN
360 370 380 390 400
LYSVYKQSFP PCMRRIFVNY IKDKHLKHWG RQQLWLFLKG AGMTLDENIQ
410 420 430 440 450
TNRSIWLQPD KFDKEHRYNI RYMYGKEGKK TDFSPYNCSK IINNFPVPSS
460 470 480 490 500
NDIHGCPFKN FDESHLKSLL YFFGLSDEQI KSIMPLKRNN EYQMACVKFF
510 520 530
METHPGSVGD GVGNHPNSYY VESRKYYKSK TSGSEKIIN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844508 Genomic DNA Translation: CAX64208.1 |
RefSeqi | XP_002808927.1, XM_002808881.1 |
Genome annotation databases
EnsemblProtistsi | CAX64208; CAX64208; PF3D7_0910900 |
GeneDBi | PF3D7_0910900.1:pep |
GeneIDi | 813386 |
KEGGi | pfa:PF3D7_0910900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844508 Genomic DNA Translation: CAX64208.1 |
RefSeqi | XP_002808927.1, XM_002808881.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | C0H531 |
Proteomic databases
PRIDEi | C0H531 |
Genome annotation databases
EnsemblProtistsi | CAX64208; CAX64208; PF3D7_0910900 |
GeneDBi | PF3D7_0910900.1:pep |
GeneIDi | 813386 |
KEGGi | pfa:PF3D7_0910900 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_0910900 |
Phylogenomic databases
HOGENOMi | CLU_026253_2_0_1 |
InParanoidi | C0H531 |
OMAi | DCHGCPY |
PhylomeDBi | C0H531 |
Enzyme and pathway databases
Reactomei | R-PFA-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-PFA-68952, DNA replication initiation R-PFA-68962, Activation of the pre-replicative complex R-PFA-69091, Polymerase switching R-PFA-69166, Removal of the Flap Intermediate R-PFA-69183, Processive synthesis on the lagging strand |
Family and domain databases
CDDi | cd07322, PriL_PriS_Eukaryotic, 1 hit |
InterProi | View protein in InterPro IPR016558, DNA_primase_lsu_euk IPR007238, DNA_primase_lsu_euk/arc |
PANTHERi | PTHR10537, PTHR10537, 1 hit |
Pfami | View protein in Pfam PF04104, DNA_primase_lrg, 1 hit |
PIRSFi | PIRSF009449, DNA_primase_large_subunit, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C0H531_PLAF7 | |
Accessioni | C0H531Primary (citable) accession number: C0H531 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 5, 2009 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |