UniProtKB - C0H4Y6 (C0H4Y6_PLAF7)
Protein
Protein disulfide-isomerase
Gene
PF3D7_0827900
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- protein disulfide isomerase activity Source: GeneDB
GO - Biological processi
- protein folding Source: GeneDB
- response to endoplasmic reticulum stress Source: GO_Central
Keywordsi
Molecular function | IsomeraseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein disulfide-isomeraseUniRule annotationARBA annotation (EC:5.3.4.1UniRule annotationARBA annotation) |
Gene namesi | ORF Names:PF3D7_0827900Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0827900 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum lumen Source: GeneDB
Other locations
- microneme Source: GeneDB
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_5005124648 | 25 – 483 | Protein disulfide-isomeraseUniRule annotationAdd BLAST | 459 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 60 ↔ 63 | Redox-activeUniRule annotation | ||
Disulfide bondi | 384 ↔ 387 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
PRIDEi | C0H4Y6 |
PTM databases
SwissPalmi | C0H4Y6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 138 | ThioredoxinInterPro annotationAdd BLAST | 116 | |
Domaini | 333 – 463 | ThioredoxinInterPro annotationAdd BLAST | 131 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 255 – 275 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Redox-active centerUniRule annotationARBA annotation, RepeatARBA annotation, SignalUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_025879_1_0_1 |
InParanoidi | C0H4Y6 |
OMAi | VAIVKMD |
PhylomeDBi | C0H4Y6 |
Family and domain databases
Gene3Di | 3.40.30.10, 3 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 3 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
C0H4Y6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRKYFSSLF LFLISFVFES FVRSHGDLFN HFVTDIHDGE LDKFITKNDI
60 70 80 90 100
VLVMFYAPWC GHCKRLIPEY NEAANMLNEK KSEIKLVSID ATSENALAQE
110 120 130 140 150
YGITGYPTLI LFNKKNKINY GGGRTAQSIV DWLLQMTGPV FSHVEGNIED
160 170 180 190 200
VLKEKKINVA FYLEYTSEDN DLYKKFNEVG DKNREIAKYF VKKNDKHNKL
210 220 230 240 250
FCFRTDEKKV EYDEKTPLEE FVTSESFPLF GEINTENYRF YAESPKELVW
260 270 280 290 300
VCATYEQYNE IKEHVRLAAQ ELRKKTHFVL LNIPEYAEHA KASLGLTEFP
310 320 330 340 350
GLAFQSNEGR YLLKNPKESL LNHNAIINFF KDVEAGKIEK SLKSEPIPED
360 370 380 390 400
DKNAPVKIVV GNSFVDVVLK SGKDVLIEIY APWCGHCKKL EPVYEDLGRK
410 420 430 440 450
LKKYDSIIVA KMDGTLNETP IKDFEWSGFP TIFFVKAGSK IPLPYEGERS
460 470 480
LKGFVDFLNK HATNTPISID GVPEFEDGTS EEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844507 Genomic DNA Translation: CAX64161.1 |
RefSeqi | XP_002808883.1, XM_002808837.1 |
Genome annotation databases
EnsemblProtistsi | CAX64161; CAX64161; PF3D7_0827900 |
GeneDBi | PF3D7_0827900.1:pep |
GeneIDi | 2655362 |
KEGGi | pfa:PF3D7_0827900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL844507 Genomic DNA Translation: CAX64161.1 |
RefSeqi | XP_002808883.1, XM_002808837.1 |
3D structure databases
SMRi | C0H4Y6 |
ModBasei | Search... |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
SwissPalmi | C0H4Y6 |
Proteomic databases
PRIDEi | C0H4Y6 |
Genome annotation databases
EnsemblProtistsi | CAX64161; CAX64161; PF3D7_0827900 |
GeneDBi | PF3D7_0827900.1:pep |
GeneIDi | 2655362 |
KEGGi | pfa:PF3D7_0827900 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_0827900 |
Phylogenomic databases
HOGENOMi | CLU_025879_1_0_1 |
InParanoidi | C0H4Y6 |
OMAi | VAIVKMD |
PhylomeDBi | C0H4Y6 |
Family and domain databases
Gene3Di | 3.40.30.10, 3 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 3 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C0H4Y6_PLAF7 | |
Accessioni | C0H4Y6Primary (citable) accession number: C0H4Y6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 5, 2009 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |