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Entry version 80 (29 Sep 2021)
Sequence version 1 (05 May 2009)
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Protein

14-3-3 protein I

Gene

14-3-3I

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which binds to its partners, usually via a phosphoserine or phosphothreonine motif (PubMed:23308157, PubMed:32484216, PubMed:32817103).

Binding generally results in the modulation of the activity and/or cellular localization of the binding partner (Probable). Via its interaction with CDPK1 and PKAr, involved in merozoite microneme secretion and thus in merozoite invasion of host erythrocytes (PubMed:32817103).

1 Publication3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone binding Source: GeneDB
  • kinase binding Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.98.1.3, the 14-3-3 protein (14-3-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein ICurated
Alternative name(s):
Pf14-3-3I1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:14-3-3I1 Publication
ORF Names:PF3D7_0818200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
PlasmoDB:PF3D7_0818200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11638, Artenimol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004530041 – 26214-3-3 protein IAdd BLAST262

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
C0H4V6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during parasite asexual blood stages, at the ring, trophozoite and schizont stages and in free merozoites (at protein level).3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable).

Forms a complex composed of CDPK1, PKA regulatory subunit PKAr and 14-3-3I; the complex is formed in merozoites in response to low extracellular level of K+ and may play a role in microneme secretion (PubMed:32817103).

Interacts with CDPK1 (when phosphorylated) in a Ca2+-independent manner; the interaction does not regulate CDPK1 catalytic activity but is required for merozoite invasion of host erythrocytes (PubMed:32484216, PubMed:32817103).

Interacts with PKA regulatory subunit PKAr (when phosphorylated) in a Ca2+-dependent manner (PubMed:32817103).

Interacts with histone H3 (when phosphorylated at 'Ser-28' or when phosphorylated at 'Ser-28' and 'Ser-32') (PubMed:23308157).

1 Publication3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
C0H4V6, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C0H4V6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058290_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
C0H4V6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPCATTG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
C0H4V6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR18860, PTHR18860, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00244, 14-3-3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000868, 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00305, 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00101, 14_3_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48445, SSF48445, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C0H4V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSEELKQL RCDCTYRSKL AEQAERYDEM ADAMRTLVEQ CVNNDKDELT
60 70 80 90 100
VEERNLLSVA YKNAVGARRA SWRIISSVEQ KEMSKANVHN KNVAATYRKK
110 120 130 140 150
VEEELNNICQ DILNLLTKKL IPNTSESESK VFYYKMKGDY YRYISEFSCD
160 170 180 190 200
EGKKEASNCA QEAYQKATDI AENELPSTHP IRLGLALNYS VFFYEILNQP
210 220 230 240 250
HQACEMAKRA FDDAITEFDN VSEDSYKDST LIMQLLRDNL TLWTSDLQGD
260
QTEEKSKDEG LE
Length:262
Mass (Da):30,193
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78CF3EE38425D91A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAX64133.1

NCBI Reference Sequences

More...
RefSeqi
XP_002808856.1, XM_002808810.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAX64133; CAX64133; PF3D7_0818200

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0818200.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2655418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0818200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844507 Genomic DNA Translation: CAX64133.1
RefSeqiXP_002808856.1, XM_002808810.1

3D structure databases

SMRiC0H4V6
ModBaseiSearch...

Protein-protein interaction databases

IntActiC0H4V6, 1 interactor

Chemistry databases

DrugBankiDB11638, Artenimol

Protein family/group databases

TCDBi8.A.98.1.3, the 14-3-3 protein (14-3-3) family

Proteomic databases

PRIDEiC0H4V6

Genome annotation databases

EnsemblProtistsiCAX64133; CAX64133; PF3D7_0818200
GeneDBiPF3D7_0818200.1:pep
GeneIDi2655418
KEGGipfa:PF3D7_0818200

Organism-specific databases

VEuPathDBiPlasmoDB:PF3D7_0818200

Phylogenomic databases

HOGENOMiCLU_058290_0_0_1
InParanoidiC0H4V6
OMAiIPCATTG
PhylomeDBiC0H4V6

Enzyme and pathway databases

ReactomeiR-PFA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
PANTHERiPTHR18860, PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244, 14-3-3, 1 hit
PIRSFiPIRSF000868, 14-3-3, 1 hit
PRINTSiPR00305, 1433ZETA
SMARTiView protein in SMART
SM00101, 14_3_3, 1 hit
SUPFAMiSSF48445, SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433I_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0H4V6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 2, 2021
Last sequence update: May 5, 2009
Last modified: September 29, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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