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Entry version 55 (08 May 2019)
Sequence version 1 (05 May 2009)
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Protein
Submitted name:

Cyclic amine resistance locus protein

Gene

PF3D7_0321900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cyclic amine resistance locus proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_0321900Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_0321900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei792 – 809HelicalSequence analysisAdd BLAST18
Transmembranei1022 – 1046HelicalSequence analysisAdd BLAST25
Transmembranei1052 – 1074HelicalSequence analysisAdd BLAST23
Transmembranei1094 – 1117HelicalSequence analysisAdd BLAST24
Transmembranei1129 – 1149HelicalSequence analysisAdd BLAST21
Transmembranei1211 – 1229HelicalSequence analysisAdd BLAST19
Transmembranei1235 – 1264HelicalSequence analysisAdd BLAST30

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21
Coiled coili996 – 1016Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
C0H483

Identification of Orthologs from Complete Genome Data

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OMAi
ALSIWIC

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008010 Tatp1

The PANTHER Classification System

More...
PANTHERi
PTHR13317 PTHR13317, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05346 DUF747, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C0H483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRITLYDFI IDEIKGGTHY NRYYSDSDCS EEECKEDENV SKNINDNKEK
60 70 80 90 100
NINDEYKYDF YKFLDHIFKA NSIPDNALDH MLNVPFFFEK LMSFSFLLCL
110 120 130 140 150
DNILYDITFM PIQVVRSICL LISLFFKNAS RNIMNIFYNF KNYKFYKYAV
160 170 180 190 200
NNYKDPKKKY KVRVIKNLNK LSYIKRKEND HMYESKYIKE KSLDESSILY
210 220 230 240 250
KKLSRNLFSF HYLNGSRFSM NASHSDDIWV DTHLEKRINI NNNNNNEEEF
260 270 280 290 300
NKSVEKQEND EHKNNICDNI TCSMKKKNIG KYFLYNRKRK MSSYNKDLKS
310 320 330 340 350
ELLKYGHKYS VLKSREDVKL LRSKSIMLNC VNNNNDDDEE KGERKKYINN
360 370 380 390 400
IKYLKNEIKL NYYFKYKGNM INDTYYSDNI YDMEKENWTK HKKNKKKINE
410 420 430 440 450
IYNTTKKEKK NFFIHFFIIL FCFGKNILQN IKYLMNYIFI KIVYFFHIHK
460 470 480 490 500
LYTFPIYKDE RKKKKMYTQS FEMNFHNTRN KQMVDFSDIH NRRGLLKIDY
510 520 530 540 550
EQGGEIHRLN SVHFEDNEEH ISSNLFIKHM YKSNEVDMGK CVNMSNKEKT
560 570 580 590 600
KQNNKNMRNL LMCAKRVIGR NNKLCASKND HIDTNKGENY SNEFVDNKFE
610 620 630 640 650
ASCEQYGKDK DTKMNDPNNN MDNNMENNND NNNDNHIIMS DVMNNASYCT
660 670 680 690 700
TEKHNNCDLL NMKANDNMFN ACSHNNDDDK IIKKGCHDLK YKKDNQNCNS
710 720 730 740 750
FMVNEKNDDK FINDTNKCNP FLVKSFYKDE KYKKSNDDFT KLNENNKKDS
760 770 780 790 800
KNMKNKKNIN NLQNMNKIKD MKKKLFKEHL NSLKLSFPEY SGIIRLSLIL
810 820 830 840 850
ICIYIFSFVD TSRIYHYIRA QPFMKLYVVL NMLEILERLL RSLGKDLIDN
860 870 880 890 900
MIRTFIRIIN LRSYICIIRN NYNEKSSINS NSNYINYVHN DNYGVNSYIY
910 920 930 940 950
KNKDNNNELI TFDNTRHINV FTNKNKDNLL NNNNNNMNYM NYMYKDSVIK
960 970 980 990 1000
NKHEYENGYV TNMDKDIFSN NFYMNNIRHH ADSFYYQNEL NSFNLNKNKE
1010 1020 1030 1040 1050
NNVRFFNNEN DKKKNNKSKI SILFPFYSVV LKFTIQYIFV LAYILIHAFM
1060 1070 1080 1090 1100
HLVRFLSLNI AINSSESTMF LILVMSNFTE IKSTVFKKFT KISLFTIVAS
1110 1120 1130 1140 1150
DAVERFYLFI DAFLVLLKMS TAYRTQNSFF SISSWLIIIL LLEVGVDWCK
1160 1170 1180 1190 1200
HSYLLKYNKL DSESLNKYFH TLLADVLISR TPNKNIYYMK DSFAVPCKNI
1210 1220 1230 1240 1250
FSFSHIPTRR LGYMSMPVVT LIVCSLPRLN YLSNISLFSF ALSIWICLFL
1260 1270 1280
FKIILSIMIV SYTISEKKQL KNLKKPYDDI SAL
Length:1,283
Mass (Da):153,405
Last modified:May 5, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1910272AB3CB8604
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAX64442.1

NCBI Reference Sequences

More...
RefSeqi
XP_002808633.1, XM_002808587.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAX64442; CAX64442; PF3D7_0321900

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_0321900.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9221783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_0321900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844502 Genomic DNA Translation: CAX64442.1
RefSeqiXP_002808633.1, XM_002808587.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAX64442; CAX64442; PF3D7_0321900
GeneDBiPF3D7_0321900.1:pep
GeneIDi9221783
KEGGipfa:PF3D7_0321900

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0321900

Phylogenomic databases

InParanoidiC0H483
OMAiALSIWIC

Family and domain databases

InterProiView protein in InterPro
IPR008010 Tatp1
PANTHERiPTHR13317 PTHR13317, 3 hits
PfamiView protein in Pfam
PF05346 DUF747, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC0H483_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C0H483
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 8, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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